REGENARATION OF MASSIVE ROTATOR CUFF TEAR

• Project/Area Number: 19791030
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: KOKUBU Takeshi Kobe University, 大学院・医学研究科, 助教 (40403266)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 肩腱板広範囲断裂 / 腱板再生 / スキャフォールド(scaffold) / ポリ-L-乳酸(PLLA) / 細胞支持体 / 生体吸収性高分子

Research Abstract

生体に吸収されるポリ-L-乳酸(PLLA)繊維を用いて作製した人工腱板を兎の肩腱板に移植したところ、理想的な人工腱板の構造として、表面は癒着を防ぐために平滑で密で、内部は細胞の取り込みと増殖を促すために厚みと空隙のある層状構造であることが分かり、細胞を播種しなくても周囲組織から人工腱板内部に細胞が誘導され肩腱板の再生に有利であると思われた。また、この人工腱板は移植後8週で正常腱板と同等の破断強度を有しており、力学的にも十分な強度を備えていた。

Research Products

• [Presentation] Regeneration of rotoator cuff tear by using a PLLA cell free scaffold in a rabbit model (2009)
  • Author(s): Inui Atsuyuki, Kokubu Takeshi, Toyokawa Narikazu, Sakata Ryousuke, Nagura Issei, Fujioka Hiroyuki, Kurosaka Masahiro, Kotera Masaru, Nishino Takashi
  • Organizer: 55th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas
• [Presentation] Regeneration of rotoator cuff tear by using a PLLA cell free scaffold in a rabbit model (2009)
  • Author(s): Inui Atsuyuki, Kokubu Takeshi
  • Organizer: 55th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas(アメリカ)
• [Presentation] ポリ-L-乳酸(PLLA)を用いたscaffoldによる肩腱板再生の検討 (2008)
  • Author(s): 乾淳幸, 国分毅, 藤岡宏幸, 名倉一成, 豊川成和
  • Organizer: 第35回日本肩関節学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 生体吸収性高分子(PLLA)を使用したcell-free scaffoldによる肩腱板修復の試み (2008)
  • Author(s): 乾淳幸, 国分毅, 藤岡宏幸, 豊川成和, 名倉一成, 黒坂昌弘, 小寺賢, 西野孝
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都国際会館
• [Presentation] Regeneration of massive rotator cuff tear using a bioabsorbable scaffold in an animal model (2008)
  • Author(s): Kokubu Takeshi, Toyokawa Narikazu, Inui Atsuyuki, Nagura Issei, Fujioka Hiroyuki, Kurosaka Masahiro
  • Organizer: 6^<th> Academic Congress of Asian Shoulder Association
  • Place of Presentation: Hong Kong
• [Presentation] Regeneration of massive rotoator cuff tear without cultured cells by using a bioabsorbale scaffold in a rabbit model (2008)
  • Author(s): Kokubu Takeshi, Inui Atsuyuki, Toyokawa Narikazu, Ikeda Risa, Nagura Issei, Nakayama Junnichi, Fujioka Hiroyuki, Kotera Masaru, Nishino Takashi, Kurosaka Masahiro
  • Organizer: 54th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: San Francisco
• [Presentation] Regeneration of massive rotator cuff tear using a bioabsorbable scaffold in an animal model (2008)
  • Author(s): Kokubu Takeshi
  • Organizer: 6^<th> Academic Congress of Asian Shoulder Association
  • Place of Presentation: Hong Kong (中国)
• [Presentation] Regeneration of massive rotoator cuff tear without cultured cells by using a bioabsorbale scaffold in a rabbit model (2008)
  • Author(s): Takeshi Kokubu
  • Organizer: 54th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: San Francisco convention center