Mechanisms of osteolysis associated with MMP2 mutation

• Project/Area Number: 19791035
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: FUKUSHI Jun-ichi Kyushu University, 大学病院, 助教 (40444806)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,890,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥690,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: 関節病学 / MMP2 / 骨破壊 / 骨溶解症 / 骨破壞

Research Abstract

Loss-of-function mutation in Matrix Metalloproteinase2 (MMP2) gene results in a rare disorder multicentric osteolysis (Winchester's syndrome). Because the phenotype of Winchester's syndrome is similar to that of MT1-MMP null mice, we sought to examine the molecular interaction between mutated MMP2 and MT1-MMP. For in vivo study, we planned to make a transgenic mouse model by overexpressing mutated MMP2.