|Budget Amount *help
¥3,890,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Loss-of-function mutation in Matrix Metalloproteinase2 (MMP2) gene results in a rare disorder multicentric osteolysis (Winchester's syndrome). Because the phenotype of Winchester's syndrome is similar to that of MT1-MMP null mice, we sought to examine the molecular interaction between mutated MMP2 and MT1-MMP. For in vivo study, we planned to make a transgenic mouse model by overexpressing mutated MMP2.