Role of heparan sulfate proteoglycan in joint development
Project/Area Number |
19791036
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Kyushu University |
Principal Investigator |
MATSUMOTO Yoshihiro Kyushu University, 医学研究院・整形外科, 助教 (10346794)
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Project Period (FY) |
2007 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
Keywords | ヘパラン硫酸 / 関節形成 / Bone morphogenetic protein / ノックアウトマウス / 関節発生 / EXT1 / Ext1 / 肢芽 / 前軟骨性凝集 |
Research Abstract |
To elucidate the pathogenesis of joint diseases, the roles of heparan sulfate (HS) in the joint development was investigated. Loss of HS in the cell surface causd the diffuse distribution of bone morphogenetic protein and the abnormal formation of mesenchymal condensation that was critical for the joint development. These results clearly indicated the essential and cell biological roles of HS in the joint development.
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Report
(6 results)
Research Products
(30 results)
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[Journal Article] Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury2009
Author(s)
Okada S, Maeda T, Ohkawa Y, Harimaya K, Saiwai H, Kumamaru H, Matsumoto Y, Doi T, Ueta T, Shiba K, Iwamoto Y.
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Journal Title
Spine 34
Pages: 1148-1152
NAID
Related Report
Peer Reviewed
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[Journal Article] Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury2009
Author(s)
Okada S, Maeda T, Ohkawa Y, Harimaya K, Saiwai H, Kumamaru H, Matsumoto Y, Doi T, Ueta T, Shiba K, Iwamoto Y.
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Journal Title
Spine. 34
Pages: 1148-1152
NAID
Related Report
Peer Reviewed
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[Presentation] Y Basic Fibroblast Growth Factor enhances invasive and metastatic phenotype of Ewing sarcoma cells by stimulating the cell migration2010
Author(s)
Kamura, S ; Matsumoto, Y ; Fukushi, J ; Fujiwara, T ; Okada, Y ; Iida, K ; Matsuda, S ; Harimaya, K ; Yoshida, T ; Matsunobu, T ; Iwamoto
Organizer
The 56th Annual Meeting of the Orthopaedic Research Society
Place of Presentation
New Orleans, USA
Year and Date
2010-02-20
Related Report
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[Presentation]
Organizer
日本結合織学会
Place of Presentation
東京
Related Report
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