EIucidation of GaInt3 functions in skeletal development and metabolism

• Project/Area Number: 19791039
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIDA Carolina Andrea Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (50437828)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 軟代謝学 / Galnt3 / knock out mouse / skeletal develonment / cartilage / bone / skeletal development

Research Abstract

LNTはムチ型糖する酵素一つでる。
研ではGalnt3子損マス作解しLNT生的能らかにすると目的とし。
Galnt3損マスはリ血症者と似し表現型し野生型マスにして血清中リは濃でFFは減少してい。
らにGalnt3-/-マス大は野生型マス大にべて量共に海綿数が増しているとがか。

Research Products

• [Journal Article] Akt regulates skeletal development through GSK3, mTOR, and FoxOs (2009)
  • Author(s): Rokutanda S
  • Journal Title: Dev. Biol 328 Pages: 78-93
  • Peer Reviewed
• [Journal Article] Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells (2008)
  • Author(s): Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, I so T, Komori T, Arai M, Kurabayashi M
  • Journal Title: Mol Cell Biol 28 Pages: 1147-60
  • Peer Reviewed
• [Journal Article] Inhibition of terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice (2008)
  • Author(s): Miyazaki T, Kanatani N, Rokutanda S,Yoshida C, Toyosawa S, Nakamura R, Takada S, Komori T
  • Journal Title: Arch Histol Cytol 71 Pages: 131-146
  • Peer Reviewed
• [Journal Article] Inhibition of terminal differentiation of odontoblasts and their trans differentiation into osteoblasts in Runx2 transgenic mice (2008)
  • Author(s): Miyazaki T
  • Journal Title: Arch. Hi stol. Cytol 71 Pages: 131-146
  • Peer Reviewed
• [Journal Article] Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. (2008)
  • Author(s): T. Tanaka
  • Journal Title: Mol Cell Biol. 28 Pages: 1147-1160
  • Peer Reviewed
• [Journal Article] Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency (2007)
  • Author(s): Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T,Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T
  • Journal Title: Dev Dyn 236 Pages: 1876-1890
  • Peer Reviewed
• [Journal Article] Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. (2007)
  • Author(s): Z. Maruyama
  • Journal Title: Dev. Dyn. 236 Pages: 1876-1890
  • Peer Reviewed
• [Presentation] Runx2 gain of function in mesenchymal cells enhanced bone fomation but inhibited cartilage fomation and limb developmentミニシンポジウム (2008)
  • Author(s): Yoshida CA, Maeno T, Kanatani N, Izumi S, Fujita T, Yamana K, Takaoka K, Komori T
  • Organizer: 第26回日本代謝学会
  • Place of Presentation: 大
• [Presentation] Akt Regerates Skeletal Development Through GSK3, mTOR, and FoxOs (2008)
  • Author(s): Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Mizuno A, Komori T
  • Organizer: 30th Annual Meeting(American society for Bone and Mineral Research)
  • Place of Presentation: カナダ(Montreal)
• [Presentation] Akt Regerates Skeletal Development Through GSK3, mTOR, and FoxOs (2008)
  • Author(s): Rokutanda S
  • Organizer: 30th Annual Meeting(ASBMR)
  • Place of Presentation: Canada Montrea
• [Presentation] Runx2 gain of function in mesenchymal cells enhanced bone fomation butinhibited cartilage fomation and limb development(ミニシンポジウム) (2008)
  • Author(s): Carolina A. Yoshida
  • Organizer: 第26回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] Runx2 functions during postnatal bone development (2007)
  • Author(s): 吉田カロリーナ、宮崎敏博、中村康平、藤田司、金谷直子、森石武史、小守壽文
  • Organizer: 日本解剖学会第63回九州支部学術会
  • Place of Presentation: 崎
  • Year and Date: 2007-10-20
• [Presentation] 軟骨内骨化におけるAktの役割 (2007)
  • Author(s): 六反田賢
  • Organizer: 日本解剖学会第63回九州支部学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2007-10-20
• [Presentation] Runx2 functions during postnatal bone development (2007)
  • Author(s): 吉田 カロリナアンドレア
  • Organizer: 日本解剖学会第63回九州支部学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2007-10-20
• [Presentation] Over-expression of Runx2 in mesenchymal cells enhanced bone formation but inhibited cartilage formation and limb development (2007)
  • Author(s): Yoshida CA, Maeno T, Kanatani N, FujitaT, Izumi S, Komori T
  • Organizer: 29th Annual Meeting(American society for Bone and Mineral Research)
  • Place of Presentation: Honolulu, (USA)
• [Presentation] The regulation of chondrocyte proliferation, function, and differentation by AKT signaling pathways (2007)
  • Author(s): Fujita T, Rokutanda S, Kanatani N,Yoshida C, Komori T
  • Organizer: 29th Annual Meeting(American society for Bone and Mineral Research)
  • Place of Presentation: Honolulu, (USA)
• [Presentation] Lamin A/CはRunx2の共役因子である (2007)
  • Author(s): 藤田 隆司
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] 軟骨内骨化におけるAktの役割 (2007)
  • Author(s): 六反田賢
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] 軟骨内骨化におけるAktの役割 (2007)
  • Author(s): 六反田賢
  • Organizer: 第49回歯科基礎医学会
  • Place of Presentation: 札幌
• [Presentation] Over-expression of Runx2 in mesenchymal cells enhanced bone formation but inhibited cartilage formation and limb development. (2007)
  • Author(s): 吉田カロリナアンドレア
  • Organizer: 29th Annual Meeting (ASBMR)
  • Place of Presentation: ホノルル
• [Presentation] The regulation of chondrocyte proliferation, function, and differentation by AKT signaling pathways. (2007)
  • Author(s): 藤田 隆司
  • Organizer: 29th Annual Meeting (ASBMR)
  • Place of Presentation: ホノルル
• [Presentation] 内軟骨性骨化におけるAktの役割 (2007)
  • Author(s): 藤田 隆司
  • Organizer: BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)
  • Place of Presentation: 横浜