Identification of DC-STAMP ligand and clarification of the mechanisms of cell-cell fusion

• Project/Area Number: 19791044
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: MIYAMOTO Takeshi Keio University, 医学部, 准教授 (70383768)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 骨 / 軟骨代謝学 / 破骨細胞 / 細胞融合 / DC-STAMP / MCP-1

Research Abstract

細胞融合因子DC-STAMPのリガンドの同定、およびDC-STAMPを介した細胞融合機構を解明するため、本研究は施行された。DC-STAMPを全身性に過剰に発現するトランスジェニックマウスを作製し、その表現型を解析することで、DC-STAMPが組織特異的に細胞融合を制御することなどを明らかにすることができた。また、DC-STAMPのリガンドの候補としてMCP-1を同定し、MCP-1欠損マウスを用いて多核の破骨細胞分化についての解析を行った。さらに、DC-STAMPの発現制御から細胞融合制御を解明するため、破骨細胞ならびにマクロファージ巨細胞におけるDC-STAMPの転写因子による発現制御機構の解明を行った。

Research Products

• [Journal Article] DC-STAMP and Osteoimmunology (2009)
  • Author(s): Miyamoto T
  • Journal Title: Inflammation and Regeneration 29(1) Pages: 59-62
  • NAID: 10024797162
  • Peer Reviewed
• [Journal Article] Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF (2009)
  • Author(s): Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP and Toyama Y
  • Journal Title: J Immunol 184(2) Pages: 2093-2101
• [Journal Article] Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity (2008)
  • Author(s): Iwasaki R, Ninomiya K, Miyamoto K, Suzuki T, Sato Y, Kawana H, Nakagawa T, Suda T, Miyamoto T
  • Journal Title: Biochem Biophys Res Commun 377 Pages: 899-904
  • Peer Reviewed
• [Journal Article] FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging (2008)
  • Author(s): Miyamoto K, Miyamoto T, Kato R, Yoshimura A, Motoyama N, Suda T
  • Journal Title: Blood 112(12) Pages: 4485-4493
  • Peer Reviewed
• [Journal Article] The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function (2008)
  • Author(s): Sawatani Y, Miyamoto T, Nagai S, Maruya M, Imai J, Miyamoto K, Fujita N, Ninomiya K, Suzuki T, Iwasaki R, Toyama Y, Shinohara M, Koyasu S and Suda T
  • Journal Title: Int Immunol 20(10) Pages: 1259-1268
  • NAID: 10024357033
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc (2008)
  • Author(s): Fujita N, Imai J, Suzuki T, Yamada M, Ninomiya K, Miyamoto K, Iwasaki R, Morioka H, Matsumoto M, Chiba K, Watanabe S, Suda T, Toyama Y, Miyamoto T
  • Journal Title: Biochem Biophys Res Commun 372(2) Pages: 367-372
• [Journal Article] A Functional Polymorphism in THBS2 that Affects Alternative Splicing and MMP Binding Is Associated with Lumbar-Disc Herniation (2008)
  • Author(s): Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S
  • Journal Title: Am J Hum Genet 82(5) Pages: 1122-1129
• [Journal Article] Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity (2008)
  • Author(s): Iwasaki R, Miyamoto T., et.al.
  • Journal Title: Biochem Biophys Res Commun 377 Pages: 899-904
  • Peer Reviewed
• [Journal Article] FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging (2008)
  • Author(s): Miyamoto K, Miyamoto T., et.al.
  • Journal Title: Blood 112 Pages: 4485-4493
  • Peer Reviewed
• [Journal Article] The role of DC-STAMP in maintenance of immune tolerance through reaulation of dendritic cell function (2008)
  • Author(s): Sawatani Y, Miyamoto T, et.al.
  • Journal Title: Int Immunol 20 Pages: 1259-1268
  • Peer Reviewed
• [Journal Article] Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner (2007)
  • Author(s): Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y
  • Journal Title: J Immunol 179(10) Pages: 6715-6724
• [Journal Article] Osteoblast-specific Angiopoietin 1 overexpression increases bone mass (2007)
  • Author(s): Suzuki T, Miyamoto T, Fujita N, Ninomiya K, Iwasaki R, Toyama Y, Suda T
  • Journal Title: Biochem Biophys Res Commun 362(4) Pages: 1019-1025
  • Peer Reviewed
• [Journal Article] Osteoclastic activity induces osteomodulin expression in osteoblasts (2007)
  • Author(s): Ninomiya K, Miyamoto T, Imai JI, Fujita N, Suzuki T, Iwasaki R, Yagi M, Watanabe S, Toyama Y, Suda T
  • Journal Title: Biochem Biophys Res Commun 362(2) Pages: 460-466
  • Peer Reviewed
• [Journal Article] TNF-{alpha}-Converting Enzyme(TACE/ADAM17)Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock (2007)
  • Author(s): Horiuchi K, Kimura T, Miyamoto T, Takaishi H, Okada Y, Toyama Y, Blobel CP
  • Journal Title: J Immunol 197(5) Pages: 2686-2689
• [Journal Article] Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction (2007)
  • Author(s): Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N
  • Journal Title: J Immunol 179(1) Pages: 636-646
• [Journal Article] Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification (2007)
  • Author(s): Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y and Suda T
  • Journal Title: J Exp Med 204(7) Pages: 1613-1323
  • Peer Reviewed
• [Journal Article] Induction of DC-STAMP by alternative activation and downstream signaling mechanisms (2007)
  • Author(s): Yagi M, Ninomiya K, Fujita N, Suzuki T, Iwasaki R, Morita K, Hosogane N, Matsuo K, Toyama Y, Suda T and *Miyamoto T
  • Journal Title: J Bone Miner Res 22(7) Pages: 992-1001
  • Peer Reviewed
• [Journal Article] Foxo3a is essential for maintenance of hematopoietic stem cell pool (2007)
  • Author(s): Miyamoto K, Araki KY, Naka K,Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama K, Harada M, Motoyama N, Suda T and Hirao A
  • Journal Title: Cell Stem Cell 1(1) Pages: 101-112
• [Journal Article] Osteoblast-specific Angiopoietin 1 overexpression increases bone mass (2007)
  • Author(s): Suzuki T. & Miyamoto T. et. a1.
  • Journal Title: Biochem Biophys Res Commun 362 Pages: 1019-1025
  • Peer Reviewed
• [Journal Article] Osteoclastic activity induces osteomodulin expression in osteoblasts (2007)
  • Author(s): Ninomiya K. & Miyamoto T., et. al.
  • Journal Title: Biochem Biophys Res Commun 362 Pages: 460-466
  • Peer Reviewed
• [Journal Article] Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification (2007)
  • Author(s): Morita K. & Miyamoto T. et. a1.
  • Journal Title: J Exp Med 204 Pages: 1613-1623
  • Peer Reviewed
• [Journal Article] Induction of DC-STAMP by alternative activation and downstream signaling mechanisms (2007)
  • Author(s): Yagi M. & Miyamoto T. et. a1.
  • Journal Title: J Bone Miner Res 22 Pages: 992-1001
  • Peer Reviewed
• [Presentation] DC-STAMP regulates bone homeostasis through cell-cell fusion of osteoclasts (2009)
  • Author(s): R. Iwasaki, H. Kawana, S. Asoda, T. Nakagawa, T. Suda, T. Miyamoto
  • Organizer: 2nd Joint Meeting International Bone & Mineral Society and Australian & New Zealand Bone & Mineral Society
  • Place of Presentation: The Sydney Convention and Exhibition Centre,Sydney Australia
• [Presentation] 第14回日本軟骨代謝学会賞受賞口演活性酸素は内軟骨性骨化において軟骨の肥大化を誘導する (2009)
  • Author(s): 宮本健史、森田晃造、戸山芳昭
  • Organizer: 第22回日本軟骨代謝学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 教育口演5 : 骨代謝の調節機構の新展開-新たな骨粗鬆症治療を目指して-骨代謝を制御する新たな創薬標的分子同定の試み-破骨細胞における細胞融合因子の同定- (2009)
  • Author(s): 宮本健史
  • Organizer: 第9回日本内分泌学会関東甲信越支部学術集会
  • Place of Presentation: 大手町サンケイプラザ
• [Presentation] 活性酸素による内軟骨性骨化制御 (2008)
  • Author(s): 宮本健史
  • Organizer: 第2回骨・軟骨フロンティア
  • Place of Presentation: 八重洲富士屋ホテル
  • Year and Date: 2008-11-29
• [Presentation] DC-STAMPは破骨細胞及び異物巨細胞の細胞融合に必須である (2008)
  • Author(s): 宮本健史、須田年生、戸山芳昭
  • Organizer: 第81回日本整形外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-25
• [Presentation] 特別講演骨代謝を制御する新たな創薬標的分子同定への挑戦 (2008)
  • Author(s): 宮本健史
  • Organizer: 第9回BMC(bone mineral conference in western Saitama)
  • Place of Presentation: 川越プリンスホテル
  • Year and Date: 2008-04-11
• [Presentation] 破骨細胞の細胞融合は骨量と骨芽細胞の活性を制御する (2008)
  • Author(s): 岩崎良太郎、河奈裕正、莇生田整治、中川種昭、宮本健史
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 1α,25(OH)2D3はIFN-βを介してヒト骨髄由来細胞の破骨細胞分化を抑制する (2008)
  • Author(s): 坂井貞興、高石官成、松崎健一郎、金子博徳、古川満、白石綾子、須田年生、宮本健史、戸山芳昭
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] SOX9プロモーターによりTACE を不活化したマウスではIL-17・G-CSFの発現に異常を呈し、骨粗鬆症、造血異常を生じる (2008)
  • Author(s): 堀内圭輔、宮本健史、秋山治彦、高石官成、中村孝志、戸山芳昭
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 副甲状腺ホルモンの骨同化作用はBcl-2によって制御される (2008)
  • Author(s): 永瀬雄一、岩澤三康、秋山達、門野夕峰、緒方直史、大島寧、中村正樹、安井哲郎、宮本健史、中村耕三、田中栄
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] DC-STAMPは破骨細胞の細胞融合を介した骨量調節因子である (2008)
  • Author(s): 宮本健史、戸山芳昭
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] SOX9プロモーターによりTACEを不活化したマウスでは成長障害と骨粗鬆症を生じる (2008)
  • Author(s): 堀内圭輔、木村徳宏、宮本健史、秋山治彦、高石官成、森岡秀夫、中村孝志、岡田保典、Carl Blobel、戸山芳昭
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] DC-STAMPは破骨細胞特異的に細胞融合を介して骨代謝を制御する (2008)
  • Author(s): 岩崎良太郎、宮本健史、莇生田整治、河奈裕正、中川種昭
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: 徳島
• [Presentation] 転写因子FoxO3aによる造血幹細胞のストレス応答および老化制御 (2008)
  • Author(s): 宮本佳奈、宮本健史、吉村昭彦、須田年生
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Basic Scientific Symposia : The New Era of Locomotive Sceince, Role of DC-STAMP in Bone and Immune System. (2008)
  • Author(s): Takeshi miyamoto
  • Organizer: 13th Congress of The Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: Pacifico Yokohama, Yokohama
• [Presentation] DC-STAMP Regulates Bone Metabolism Through Cell-cell Fusion of Osteoclasts. (2008)
  • Author(s): R. Iwasaki, T. Miyamoto, H. Kawana, T. Nakagawa, T. Suda
  • Organizer: 30th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Palais des congres de Montreal, Montreal, Quebec, Canada
• [Presentation] DHCR24 Gene Is Mandatory for the Proper Growth of Long Bone (2008)
  • Author(s): R. Mizra, T. Miyamoto, T. Kaji, Y. Murata, H
  • Organizer: 30th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Seo. Palais des congres de Montreal,Montreal, Quebec, Canada
• [Presentation] IFN-beta Is a Key Molecule in Inhibition of Human Osteoclast Differentiation by 1alpha, 25-dihydroxyvitamin D3 (2008)
  • Author(s): S. Sakai, H. Takaishi, K. Matsuzaki, H. Kaneko, M. Furukawa, A. Shiraishi, T. Suda, T. Miyamoto, Y. Toyama
  • Organizer: 30th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Palais des congres de Montreal, Montreal, Quebec, Canada
• [Presentation] Loss of Single Bim Allele Recovers the Defective Osteoclast Function in bcl2-/- Mice but Dose not Restore the Anabolic Action of PTH (2008)
  • Author(s): Y. Nagase, M. Iwasawa, T. Akiyama, Y. Kadono, N. Ogata, Y. Oshima, M. Nakamura, T. Yasui, T. Miyamoto, K. Nakamura, S. Tanaka
  • Organizer: 30th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Palais des congres de Montreal, Montreal, Quebec, Canada
• [Presentation] 細胞融合因子DC-STAMPからみた骨免疫と再生(シンポジウム「骨免疫と再生」) (2008)
  • Author(s): 宮本健史
  • Organizer: 第29回日本炎症・再生医学会
  • Place of Presentation: 都市センターホテル
• [Presentation] DC-STAMP is essential for osteoclastic cell-cell fusion (2008)
  • Author(s): R. Iwasaki, T. Miyamoto, H. Kawana, S. Asoda, T. Suda, T. Nakagawa
  • Organizer: International Association for Dental Research
  • Place of Presentation: Metro Toronto Convention Centre, ON, Canada,
• [Presentation] 奨励賞受賞講演DC-STAMPは破骨細胞及び異物巨細胞の細胞融合に必須である (2008)
  • Author(s): 宮本健史、須田年生、戸山芳昭
  • Organizer: 第81回日本整形外科学会総会
  • Place of Presentation: ロイトン札幌他
• [Presentation] 一般口演骨: 7回膜貫通型受容体蛋白DC-STAMPは破骨細胞特異的に細胞融合を制御する (2008)
  • Author(s): 岩崎良太郎、宮本健史、河奈裕正、莇生田整治、中川種昭
  • Organizer: 第62回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 口演5 : 発生と分化1活性酸素は内軟骨性骨化において軟骨の肥大化を誘導する (2008)
  • Author(s): 宮本健史、戸山芳昭
  • Organizer: 第21回軟骨代謝学会
  • Place of Presentation: 京都テルサ
• [Presentation] 骨代謝研究の最近の進歩 (2007)
  • Author(s): 宮本 健史
  • Organizer: 第9回日本骨粗鬆症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-14
• [Presentation] Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification (2007)
  • Author(s): Takeshi Miyamoto
  • Organizer: 1st G-COE international symposium [Gas Biology and Medicine]
  • Place of Presentation: Nobel Forum, Karolinska Institutet,Stockholm, Sweden
  • Year and Date: 2007-11-07
• [Presentation] 細胞融合因子DC-STAMPによる骨免疫制御 (2007)
  • Author(s): 宮本 健史
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2007-10-20
• [Presentation] Cell-cell fusion of osteoclasts is stimulated in DC-STAMP transgenic mice (2007)
  • Author(s): Iwasaki R. & Miyamoto T. et. a1.
  • Organizer: 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Honolulu
  • Year and Date: 2007-09-18
• [Presentation] DC-STAMPは破骨細胞の細胞融合に必須である (2007)
  • Author(s): 宮本 健史
  • Organizer: 第49回歯科基礎医学会学術大会・総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-29
• [Presentation] DC-STAMP is essential for cell-cell fusion in osteoclasts and macrophages (2007)
  • Author(s): Miyamoto T.
  • Organizer: Gordon Research Conference (CELL-CELL FUSION)
  • Place of Presentation: New London
  • Year and Date: 2007-07-05
• [Presentation] DC-STAMPは破骨細胞及びマクロファージ巨細胞の細胞融合に必須である (2007)
  • Author(s): 宮本 健史
  • Organizer: 第39回日本結合組織学会・第54回マトリックス研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-09
• [Presentation] 破骨細胞と細胞融合(イブニングセミナー「骨代謝研究の最近の進歩」) (2007)
  • Author(s): 宮本健史
  • Organizer: 第9回日本骨粗鬆症学会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 細胞融合因子DC-STAMPによる骨免疫制御(シンポジウム「骨免疫学」) (2007)
  • Author(s): 宮本健史
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] 骨形成における血管新生因子Angiopoietin1の機能解析 (2007)
  • Author(s): 鈴木亨、宮本健史、藤田順之、須田年生、戸山芳昭
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] 骨芽細胞に発現するOsteomodulinの同定と組織学的検討 (2007)
  • Author(s): 二宮研、宮本健史、藤田順之、鈴木亨、須田年生、戸山芳昭
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] 敗血症性ショックにおけるTACE/ADAM17の機能解析 (2007)
  • Author(s): 堀内圭輔、木村徳宏、宮本健史、岡田保典、Carl Blobel、戸山芳昭
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] 抗アポトーシス分子Bcl-2は骨組織ホメオスタシスを制御する (2007)
  • Author(s): 永瀬雄一、秋山達、門野夕峰、宮本健史、田中栄、中村耕三
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] Regulation of Skeletal Homeostasis by Anti-apoptotic Molecule Bcl-2 (2007)
  • Author(s): Y. Nagase, M. Iwasawa, T. Akiyama, Y. Kadono, T. Miyamoto, Y. Oshima, M. Nakamura, T. Yasui, K. Nakamura, S. Tanaka
  • Organizer: 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii
• [Presentation] Cell-cell fusion of osteoclasts is stimulated in DC-STAMP transgenic mice (2007)
  • Author(s): R Iwasaki, T. Miyamoto, H. Kawana, T. Nakagawa, T. Suda
  • Organizer: 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii
• [Presentation] Overexpression of osteoblast specific Angiopoietin1 increases bone mass (2007)
  • Author(s): T. Suzuki, T. Miyamoto, N. Fujita, M. Yagi, K. Ninomiya, R. Iwasaki, Y. Toyama, T. Suda
  • Organizer: 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii
• [Presentation] Isolation and Immunohistochemical Analysis of Osteomodulin Expressed in Osteoblast (2007)
  • Author(s): K. Ninomiya, T. Miyamoto, N. Fujita, T. Suzuki, R. Iwasaki, M. Yagi, Y. Toyama, T. Suda
  • Organizer: 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii
• [Presentation] DC-STAMPは破骨細胞の細胞融合に必須である(サテライトシンポジウム「破骨細胞の一生 : 細胞分化から細胞死まで」) (2007)
  • Author(s): 宮本健史
  • Organizer: 第49回歯科基礎医学会学術大会・総会
  • Place of Presentation: 北海道大学
• [Presentation] 骨形成における血管新生因子Angiopoietin1の機能解析 (2007)
  • Author(s): 鈴木亨、宮本健史、藤田順之、戸山芳昭、須田年生
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 抗アポトーシス分子Bcl-2は骨組織ホメオスタシスを制御する (2007)
  • Author(s): 永瀬雄一、岩澤三康、秋山達、門野夕峰、大島寧、中村正樹、安井哲郎、宮本健史、田中栄、中村耕三
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] TACEはin vivoにおいてTNF-aの可溶化に必須の分子である (2007)
  • Author(s): 堀内圭輔、宮本健史、高石官成、戸山芳昭
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 骨芽細胞に発現するOsteomodulinの同定と組織学検討 (2007)
  • Author(s): 二宮研、宮本健史、藤田順之、鈴木亨、戸山芳昭、須田年生
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] DC-STAMP is essential for cell-cell fusion in osteoclasts and macrophages (2007)
  • Author(s): Takeshi Miyamoto
  • Organizer: Gordon Research Conference(CELL-CELL FUSION)
  • Place of Presentation: Colby-Sawyer College, New London, NH
• [Presentation] (シンポジウム「結合組織疾患における最近のトピックス」)DC-STAMPは破骨細胞及びマクロファージ巨細胞の細胞融合に必須である (2007)
  • Author(s): 宮本健史
  • Organizer: 第39回日本結合組織学会・第54回マトリックス研究会
  • Place of Presentation: 北とぴあ