Role of notochord for intervertebral disc degeneration
| Project/Area Number |
19791045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
TSUJI Takashi Keio University, 医学部, 助教 (60296639)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 椎間板 / 変性 / 髄核 / 脊索 / 線維輪 / 終板 |
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| Research Abstract |
The levels of expression of TIMP-3 in the notochordal NP were significantly lower in 160-week-old rabbits than those in 4-week-old rabbits. The decrease in the expression of TIMP-3 possibly mediated in part by TGF-β1 cause an imbalance of ADAMTS4/TIMP-3 ratio at the transition period from the notochordal to the fibrocartilaginous NP.
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Report
(6 results)
Research Products
(42 results)
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[Presentation] A Possible Link between Estrogen and TGF-l3 Signaling in Intervertebral Disc Metabolism: Estrogen Receptor aDependent Regulation of Type II Collagen Gene Expression in Chondrocytic Cells2009
Author(s)
Masanori Kato, Nobuyuki Fujita, Hironari Takaishi, Takahide Tohmonda, Masaki Yoda, Tokuhiro Kimura, Toshiyuki Kikuchi, Naoburni Hosogane,Takashi Tsuji, Morio Matsumoto, Yoshiaki Toyama, 1 Kazuhiro Chiba
Organizer
Orthopaedic research society
Place of Presentation
LasVegas USA
Related Report
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[Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats2008
Author(s)
Kato Masanori, Fujita Nobuyuki, Takaishi Hironari, Takito Jiro Kimura, Tokuhiro Kikuchi, Hosogane Naobumi, Tsuji Takashi, Matsumoto, Morio, Toyama, Yoshiaki, Chiba, Kazuhiro
Organizer
ORS
Place of Presentation
San Fancisco
Year and Date
2008-03-03
Related Report
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[Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats.2008
Author(s)
Kato Masanori, Fujita Nobuyuki, Takaishi Hironari, Takito Jiro, Kimura Tokuhiro, Hosogane Naobumi, Tsuji, Takashi, Matsumoto, Morio, Toyama Yoshiaki, Chiba Kazuhiro.
Organizer
Annual Meeting of Orthopaedic Research Society.
Place of Presentation
San Francisco, CA USA.
Year and Date
2008-03-02
Related Report
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[Presentation] Expression of TIMP-3 and Aggrecanases associated with transition from notochordal nucleus pulposus to fibrocartilaginous nucleus pulposus in rabbit intervertebral disc.2007
Author(s)
Tsuji T, Chiba K, Fujita N, Miyake A, Kato M, Watanabe K, Ishii K, Takaishi H, Nakamura M, Matsumoto M, Toyama Y.
Organizer
International Society for the study of the Lumbar Spine
Place of Presentation
Hong Kong, China.
Year and Date
2007-06-10
Related Report
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[Presentation] Express ion of TIMP-3 and Aggrecanases associated with transition from notochordal nucleus pulposus to fibrocartilaginous nucleus pulposus in rabbit interverte bral disc2007
Author(s)
Tsuji T, Chiba K, Fujita N, Miyake A, Kato M, Watanabe K, Ishii K, Takaishi H, Nakamura M, Matsumoto M, Toyama Y
Organizer
International Society for the study of the Lumbar Spine
Place of Presentation
Hong Kong
Related Report
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