The mechanism of cannabinoid-induced analgesic effect at the level of the spinal cord

Research Project

Project/Area Number	19791075
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Sapporo Medical University
Principal Investigator	KIYA Tomohiro Sapporo Medical University, 医学部, 研究員 (10438046)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords	疼痛治療学 / カンナビノイド / in vivoパッチクランプ / 脊髄鎮痛 / EPSC / 疼痛モデル / in vivo / パッチクランプ / CBl受容体
Research Abstract	This study focused on the cannabinoid-induced analgesic effect at the level of the spinal cord. Spinal administration of ACEA inhibited the withdrawal latency to noxious heat. Next the change of EPSC in chemotherapy-induced peripheral neuropathy model was examined using in vivo patch-clamp recording. Spontaneous EPSCs and cold stimuli-induced EPSCs increased in the neuropathy model compared to those in sham model, and they were suppressed after ACEA perfusion. The spinal administration of cannabinoids produces the analgesic effects by inhibition of EPSC.

Report

(4 results)