| Project/Area Number |
19791076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NIIYAMA Yukitoshi Sapporo Medical University, 医学部, 講師 (90423764)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | transient receptor vanilloid subfamily 1 / runt-related transcription factor 1 / 骨がん / 後根神経節 / 疼痛 / 麻酔 / カプサイシン / 電流 / TRP |
|---|
| Research Abstract |
I have reported that cancer-related chemical mediators including endothelin-1 sensitize transient receptor vanilloid subfamily 1 (TRPV1), and the expression of TRPV1 in the peripheral neurons is increased, leading to bone cancer pain. However, the mechanisms underlying up-regulation of TRPV1 has been elucidated. Here, I focused on a transcriptional factor runt-related transcription factor 1(Runx1), which was expressed in the peripheral neurons, to clarify the mechanisms of up-regulation of TRPV1 in the bone cancer condition.
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