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Development of a new procedure for measurement of brain water content -aquaporin as a target of a new therapy for brain edema-

Research Project

Project/Area Number 19791078
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya City University

Principal Investigator

HIRATE Hiroyuki  Nagoya City University, 大学院・医学研究科, 助教 (20363939)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords蛋白質 / 脳・神経 / 脳神経疾患 / アクアポリン4 / マニトール / 脳浮腫 / 脳水分測定
Research Abstract

Brain edema leading to an expansion of brain volume has a crucial impact on morbidity and mortality following brain damages. It is necessary to develop a new procedure for measurement of brain water content for experiments. Here, I have developed a new method of measurement of focal brain water content by Karl-Fischer titration. The method will be useful for studies of brain edema.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.2008

    • Author(s)
      Morisima M, Aoyama M, Iida Y, Yamamoto N, Hirate Hiroyuki, Arima H, Fujita Y, Sasano H, Tsuda T, Katsuya H, Asai K, Sobue K
    • Journal Title

      Neuroscience Research 61(1)

      Pages: 18-26

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳浮腫の発症機序と水チャネル「アクアポリン」の機能2008

    • Author(s)
      祖父江和哉、平手博之、飯田裕子、高柳猛彦
    • Journal Title

      Anesthesia 21Century 10

      Pages: 1835-1839

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 硬膜外ブロック後に-過性硬膜外血腫を生じた高度脊椎変形を持つ一症例2010

    • Author(s)
      平手博之、蓑輪暁久
    • Organizer
      第22回日本老年麻酔学会
    • Place of Presentation
      横浜シンポジア (横浜)
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット敗血症モデルの副腎におけるアクアポリン(AQP)の発現2009

    • Author(s)
      高柳猛彦、平手博之、藤田義人、松本麗、祖父江和哉、浅井清文
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-17
    • Related Report
      2009 Final Research Report
  • [Presentation] マン二トールによる水チャネルaquaporin4を介した脳水分量調節機構2009

    • Author(s)
      平手博之、有馬一、高柳猛彦、飯田裕子、伊藤弘晃、成松紀子、藤田義人、薊隆文、浅井清文、祖父江和哉
    • Organizer
      36回日本集中治療医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-26
    • Related Report
      2009 Final Research Report
  • [Presentation] マンニトールによる水チャネルaquaporin4を介した脳水分量調節機構2009

    • Author(s)
      平手博之
    • Organizer
      第36回日本集中治療医学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-02-26
    • Related Report
      2008 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科麻酔・危機管理医学分野ホームページ

    • URL

      http://www.ncu-masui.jp

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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