The effect of genetic polymor phism on propofol metabolism

• Project/Area Number: 19791085
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: TOKINAGA Yasuyuki Wakayama Medical University, 医学部, 助教 (60438281)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,850,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 遺伝子多型 / プロポフォール / 遺伝子発現 / SNP / 薬物代謝 / 遺伝子頻度 / UDP-Glucuronosvltransferase 1A9 / Pharmacogenetics / 一塩基多型

Research Abstract

Propofol is widely using anesthetic drug. Propofol is mainly catalyzed by UDP-Glucuronosyltransferase 1A9(UGT1A9). It has been shown that several single nucleotide polymorphisms (SNPs) in regulatory region of UGT1A9 gene are associated with the expression level of UGT1A9 protein. The purpose of this study is to elucidate the relationship between these SNPs and the rate of propofol metabolism in vivo in Japanese population. The blood samples were collected from 50 persons who were living in Wakayama, Japan. Genomic DNA was prepared from each sample. Genotypes of these allele were all wild type.

Research Products

• [Presentation] The Allelic frequenciea of Propofol-Metabolize Enzyme Gene in Japanese Population (2010)
  • Author(s): Yasuyuki Tokinaga, M.D., Yoshiki Kimoto, M.D., Kazuhisa Suhimoto, M.D., Koji Ogawa, M.D., Yoshio Hatano, M.D.
  • Organizer: American Society of Anesthesiologists Annuai Meeting 2010
  • Place of Presentation: San Diego, CaLIFORNIA USA
  • Year and Date: 2010-10-18
• [Presentation] The Allelic Frequencies of Propofol-Metabolize Enzyme Gene in Japanese Population (2010)
  • Author(s): Y.Tokinaga, Y.Kimoto, et al.
  • Organizer: American Society of Anesthesiologists Annual Meeting 2010
  • Place of Presentation: San Diego, California
  • Year and Date: 2010-10-18
• [Presentation] プロポフォール代謝酵素遺伝子における1塩基多型の検討 (2010)
  • Author(s): 時永泰行、木本吉紀、小川幸志、谷奥匡、江尻加名子、畑埜義雄
  • Organizer: 社団法人日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡(日本)
  • Year and Date: 2010-06-04
• [Presentation] プロポフォール代謝酵素遺伝子における1塩基多型の検討 (2010)
  • Author(s): 時永泰行、木本吉紀, ら
  • Organizer: 社団法人日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04