Overcoming therapeutic resistance of genitourinary cancer using heat shock protein 90 inhibitors

• Project/Area Number: 19791102
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KOGA Fumitaka Tokyo Medical and Dental University, 医学部附属病院, 助教 (10285851)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: 膀胱癌 / 治療耐性 / 化学療法 / 放射線療法 / ヒートショックプロテイン90阻害剤

Research Abstract

ヒートショックプロテイン90(Hsp90)は癌の治療耐性を規定する様々な蛋白の発現と機能を担保する。細胞毒性を示さない低用量のHsp90阻害剤は、これら治療耐性関連蛋白の発現と機能を抑制し、膀胱癌細胞の化学放射線療法治療耐性克服を可能とした。Hsp90 阻害剤は、正常尿路上皮細胞に対しては、癌細胞にみられた強い治療増感効果を示さなかったことから、その増感作用は癌細胞選択的であることが示唆された。

Research Products

• [Journal Article] Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat shock protein 90 (2009)
  • Author(s): Koga F, Kihara K, Neckers L
  • Journal Title: Anticancer Res 29 Pages: 797-808
  • Peer Reviewed
• [Journal Article] Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat shock protein 90. (2009)
  • Author(s): Koga F, Kihara K, Neckers L
  • Journal Title: Anticancer Research 29 Pages: 797-808
  • Peer Reviewed
• [Journal Article] Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat shock protein 90. (2009)
  • Author(s): Koga F. Kihara K, Neckers L.
  • Journal Title: Anticancer Research 29 Pages: 797-808
  • Peer Reviewed
• [Journal Article] Low-dose chemoradiotherapy followed by partial or radical cystectomy against muscle-invasive bladder cancer: an intention-to-treat survival analysis (2008)
  • Author(s): Koga F, Yoshida S, Kawakami S, Kageyama Y, Yokoyama M, Saito K, Fujii Y, Kobayashi T, Kihara K
  • Journal Title: Urology 72 Pages: 384-388
  • Peer Reviewed
• [Journal Article] Low-dose chemoradiotherapy followed by partial or radical cystectomy against muscle-invasive bladder cancer : an intention-to-treat survival analysis (2008)
  • Author(s): Koga F, Yoshida S, Kawakami S, Kageyama Y, Yokoyama M, Saito K, Fujii Y, Kobayashi T, Kihara K.
  • Journal Title: Urology 72 Pages: 384-388
  • Peer Reviewed
• [Journal Article] Low-dose chemoradiotherapy followed by partial or radical cystectomy against muscle-invasive bladder cancer : an intention-to-treat survival analysis. (2008)
  • Author(s): Koga F, Yoshida S, Kawakami S, Kageyama Y, Yokoyama M, Saito K, Fujii Y, Kobayashi T, Kihara K.
  • Journal Title: Urology 72 Pages: 384-388
  • Peer Reviewed
• [Journal Article] 浸潤性膀胱癌に対する低侵襲根治的膀胱温存療法:低用量化学放射線療法とミニマム創内視鏡下膀胱部分切除 (2007)
  • Author(s): 古賀文隆、木原和徳、増田 均、川上 理
  • Journal Title: 泌尿器外科 20 Pages: 871-874
• [Journal Article] 浸潤性膀胱癌に対する低侵襲根治的膀胱温存療法 : 低容量化学放射線療法とミニマム創内視鏡下膀胱部分切除 (2007)
  • Author(s): 古賀文隆, 木原和徳, 増田均, 川上理.
  • Journal Title: 泌尿器外科 20 Pages: 871-874
• [Journal Article] Favourable outcomes of clinical stage T3N0M0 bladder cancer patients treated with induction low-dose chemoradiotherapy plus partial or radical cystectomy versus immediate radical cystectomy: a single-institutional retrospective comparative study
  • Author(s): Koga F, Kihara K, Fujii Y, Yoshida S, Saito K, Masuda H, Kageyama Y, Kawakami S
  • Journal Title: BJU Int(in press)
  • Peer Reviewed
• [Journal Article] Favourable outcomes of clinical stage T3NOMO bladder cancer patients treated with induction low-dose chemoradiotherapy plus partial or radical cystectomy versus immediate radical cystectomy : a single-institutional retrospective comparative study.
  • Author(s): Koga F, Kihara K, Fujii Y, Yoshida S, Saito K, Masuda H, Kageyama Y, Kawakami S.
  • Journal Title: BJU International (印刷中)
  • Peer Reviewed
• [Journal Article] Favourable outcomes of clinical stage T3NOMO bladder cancer patients treated with induction low-dose chemoradiotheraphy plus partial or radical cystectomy versus immediate radical cystectomy : a single-insutitutional retrospective comparative study.
  • Author(s): Koga F. Kihara K, Fujii Y, Yoshida S, Saito K, Masuda H, Kageyama Y, Kawakami S.
  • Journal Title: BJU International (印刷中)
  • Peer Reviewed
• [Presentation] ビデオシンポジウム:浸潤性膀胱癌に対する低侵襲根治的膀胱温存療法 (2008)
  • Author(s): 古賀文隆、木原和徳
  • Organizer: 第33回日本外科系連合学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-13
• [Presentation] Favorable outcomes of T3N0M0 bladder cancer patients treated with induction low-dose chemoradiotherapy plus partial or radical cystectomy compared to immediate radical cystectomy (2008)
  • Author(s): Koga F, Kawakami S, Yoshida S, Saito K, Fujii Y, Kihara K
  • Organizer: 23rd annual EAU congress
  • Place of Presentation: Milan, Italy
  • Year and Date: 2008-05-26
• [Presentation] Favorable outcomes of T3NOMO bladder cancer patients treated with inductoin low-dose chemoradiotherapy plus partial of radical cystectomy compared to immediate radical cystectomy. (2008)
  • Author(s): Koga F, Kawakami S, Yoshida S, Saito K, Fujii Y, Kihara K.
  • Organizer: 23rd annual EAU congress
  • Place of Presentation: Milan, Italy
  • Year and Date: 2008-03-26
• [Presentation] 特別講演:Hsp90 阻害剤による癌の浸潤・転移抑制 (2007)
  • Author(s): 古賀文隆、木原和徳、Neckers Len
  • Organizer: 第11回バイオ治療法研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-01
• [Presentation] 特別講演 : Hsp90阻害剤による癌の浸潤・転移抑制. (2007)
  • Author(s): 古賀文隆, 木原和徳, Neckers Len.
  • Organizer: 第11回バイオ治療法研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-01
• [Presentation] 浸潤性膀胱癌に対する低侵襲根治的膀胱温存療法 (2007)
  • Author(s): 古賀文隆、吉田宗一郎、影山幸雄、田所 学、酒井康之、齋藤一隆、増田 均、小林 剛、川上 理、木原和徳
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-26
• [Presentation] Induction low-dose chemoradiotherapy against muscle-invasive bladder cancer: possible improvement of survival and favorable local control for bladder-preserved patients (2007)
  • Author(s): Koga F, Yoshida S, Kageyama Y, Kawakami S, Fujii Y, Saito K, Masuda H, Kobayashi T, Kihara K
  • Organizer: 29th Congress of the SIU
  • Place of Presentation: Paris, France
  • Year and Date: 2007-09-04
• [Presentation] Induction low-dose chemoradiotherapy against muscle-invasive bladder cancer : possible improvement of survival and favorable local control for bladder-preserved patients. (2007)
  • Author(s): Koga F, Yoshida S, Kageyama Y, Kawakami S, Fujii Y, Saito K, Masuda H, Kobayashi T, Kihara K.
  • Organizer: 29^<th> Congress of the SIU
  • Place of Presentation: Paris, France
  • Year and Date: 2007-09-04