miR-15a/16-1 functions as a tumor suppressor for prostate cancer by targeting multiple oncogenes

• Project/Area Number: 19791126
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Teikyo University
• Principal Investigator: KOJIM Satoko Teikyo University, 医学部, 准教授 (10345019)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 前立腺癌 / microRNA / アポトーシス / ホルモン抵抗性 / BCL-2

Research Abstract

microRNA15a/16-1はヒト前立腺癌および、前立腺癌細胞株において発現が低下している。その機序として、BCL2を介した細胞死の増加と細胞増殖の抑制を認めた。ホルモン抵抗性前立腺癌においてもアポトーシスの亢進が認められ、microRNAがホルモン抵抗性前立腺癌の治療に有用である可能性が示唆された。

Research Products

• [Journal Article] Implications of IGF-I for prostate cancer therapies (2009)
  • Author(s): Satoko Kojima
  • Journal Title: International Journal of Urology vol 16 Pages: 161-167
• [Journal Article] 内分泌療法の長期的な問題点 (2009)
  • Author(s): 小島聡子
  • Journal Title: Urology View Vol. 7. No. 2 Pages: 109-113
• [Journal Article] Implications of IGF-I for prostate cancer therapies (2009)
  • Author(s): Satoko Kojima
  • Journal Title: International Journal of Urology 16 Pages: 161-167
  • Peer Reviewed
• [Presentation] miR-15a functions as a tumor suppressor for prostate cancer by targeting multiple oncogenes (2009)
  • Author(s): 小島聡子
  • Organizer: ヨーロッパ泌尿器科学会(EUA)
  • Place of Presentation: ストックホルム
  • Year and Date: 2009-03-21
• [Presentation] 前立腺癌におけるmiR-15aの発現と機能解析 (2009)
  • Author(s): 小島聡子
  • Organizer: 泌尿器分子細胞研究会
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-02-14
• [Presentation] miR-15a functions as a tumor suppressor for prostate cancer by targeting multiple oncogenes (2009)
  • Author(s): 小島聡子
  • Organizer: ヨーロッパ泌尿器科学会
  • Place of Presentation: ストックホルム、スイス
• [Presentation] miR-15a/16-1 cluster controls prostate cancer proliferation by targeting Bc12 activities (2008)
  • Author(s): 小島聡子
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-31
• [Presentation] miR-15a/16-1 duster controls prostate cancer proliferation by targeting Bc12 activities (2008)
  • Author(s): 小島聡子
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-31