Study of the mechanism for controlling of sperm function via lipid lafts with proteins secreted by seminal vesicle
Project/Area Number |
19791128
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Urology
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Research Institution | Toin University of Yokohama |
Principal Investigator |
YOSHIDA Kaoru Toin University of Yokohama, 先端医用工学センター, 講師 (70398973)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,730,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
Keywords | 精子 / 受精能 / 膜ラフト / 糖脂質 / 膜タンパク質 |
Research Abstract |
精嚢分泌タンパク質Semenogelinは精子運動超活性化の抑制因子であり、これまでの先体胞反応およびタンパク質チロシンリン酸化抑制因子であるという報告と合わせて精子受精能抑制因子であることが示された。また、細胞膜脂質ラフト構造との直接の関与は不明だが、精子細胞膜に結合してその流動性と機能に影響を与えていることが示唆された。
|
Report
(4 results)
Research Products
(16 results)
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[Journal Article] Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans2009
Author(s)
Yoshida K, Krasznai ZT, Krasznai Z, Yoshiike M, Kawano N, Yoshida M, Morisawa M, Toth Z, Bazsane ZK, Marian T, Iwamoto T
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Journal Title
Cell Motil Cytoskeleton 66(2)
Pages: 99-108
Related Report
Peer Reviewed
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[Journal Article] Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans2009
Author(s)
Yoshida K, Krasznai ZT, Krasznai Z, Yoshiike M, Kawano N, Ycshida M, Morisawa M, Toth Z, Bazsane ZK, Marian T, Iwamoto T
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Journal Title
Cell Motil Cytoskeleton 66(2)
Pages: 99-108
Related Report
Peer Reviewed
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