Estrogen signaling ability in human endometrial cancer and breastcancer through the cancer-stromal interaction.

• Project/Area Number: 19791132
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: MATSUMOTO Mitsuyo Tohoku University, 大学院・医学系研究科, 非常勤講師 (80400448)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 子宮体癌 / 乳癌 / エストロゲン / ERE活性 / 臨床検体 / 乳がん / マイクロアレイ / 癌細胞-間質細胞相互作用

Research Abstract

The estrogen pathway plays an important role in the etiology of human endometrial cancer and breast cancer. However, there is not report that evaluated estrogen responsiveness of specimens from individual patients. We established new reporter analysis system for detection of estrogen signal activity in primary tumor cells. Our results underscore the importance of tailoring therapy to individual patients with estrogen-dependent tumor, and our assay provide a way to accomplish this.

Research Products

• [Journal Article] 3-Dimentional Microarray Analysis of Estrogen Signal-related Genes in Breast Cancer Tissues. (2009)
  • Author(s): Matsumoto M Sakamoto H, Yamaguchi Y, Seino Y, Takei H, Kurosumi M, Sasano H, Yaegashi N, Hayashi S
  • Journal Title: Anti-cancer Research 29 Pages: 3971-3976
  • Peer Reviewed
• [Journal Article] Local biosynthesis of estrogen in human endometrial carcinoma through tumor-stromal cell interactions. (2009)
  • Author(s): akahashi-Shiga N, Utsunomiya H, Miki Y, Nagase S, Kobayashi R, Matsumoto M, Niikura H, Ito K, Yaegashi N
  • Journal Title: Clinical Cancer Research 15 Pages: 6028-6034
  • Peer Reviewed
• [Journal Article] Generation of a syngeneic mouse model to study the intraperitoneal dissemination of ovarian cancer with in vivo luciferase imaging. (2009)
  • Author(s): Toyoshima M, Tanaka Y, Matumoto M, Yamazaki M, Nagase S, Sugamura K, Yaegashi N
  • Journal Title: Luminescence Published (online)
  • Peer Reviewed
• [Journal Article] 3-Dimentional Microarray Analysis of Estrogen Signal-related Genes in Breast Cancer Tissues (2009)
  • Author(s): Matsumoto Mitsuyo
  • Journal Title: Anti-cancer Research 29 Pages: 3971-3976
  • Peer Reviewed
• [Journal Article] Local biosynthesis of estrogen in human endometrial carcinoma through tumor-stromal cell interactions (2009)
  • Author(s): Takahashi-Shiga Naomi
  • Journal Title: Clinical Cancer Research 15 Pages: 6028-6034
  • Peer Reviewed
• [Journal Article] Generation of a syngeneic mouse model to study the intraperitoneal dissemination of ovarian cancer with in vivo luciferase imaging (2009)
  • Author(s): Toyoshima Masafumi
  • Journal Title: Luminescence (Published online)
  • Peer Reviewed
• [Journal Article] Midkine and its clinical significance in endometrial cancer. (2008)
  • Author(s): Tanabe K, Matsumoto M, Ikematsu S, Nagase S, Hatakeyama A, Takano T, Niikura H, Ito K, Kadomatsu K, Hayashi S, Yaegashi N
  • Journal Title: Cancer Science 99 Pages: 1125-1130
  • Peer Reviewed
• [Journal Article] The expression of retinoic acid receptors in human endometrial carcinoma. (2008)
  • Author(s): Tanabe K, Utsunomiya H, Tamura M, Niikura H, Takano T, Yoshinaga K, Nagase S, Suzuki T, Ito K, Matsumoto M, Hayashi S, Yaegashi N
  • Journal Title: Cancer Science 99 Pages: 267-271
  • NAID: 10024002120
  • Peer Reviewed
• [Journal Article] Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction. (2008)
  • Author(s): Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H, Yaegashi N, Hayashi S
  • Journal Title: Endocrine-Related Cancer 15 Pages: 451-463
  • Peer Reviewed
• [Journal Article] Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction (2008)
  • Author(s): Mitsuyo Matsumoto
  • Journal Title: Endocrine-Related Cancer 15 Pages: 1-14
  • Peer Reviewed
• [Presentation] Analysis of transcriptional activity of estrogen receptor by ERE-GFP assay in primary breast cancer and its clinical significance (2009)
  • Author(s): 松本光代
  • Organizer: 67th Annual Meeting of the Japanease Cancer-Association
  • Place of Presentation: 愛知・名古屋国際会議場
  • Year and Date: 2009-10-28
• [Presentation] Tumor-stromal Interaction through Estrogen-Signaling Pathway Analyzed by GFP Assay in Human Endometrial Cancer (2009)
  • Author(s): 松本光代
  • Organizer: 癌研究に係る特定領域研究若手研究者ワークショップ
  • Place of Presentation: 長野・アートランドホテル蓼科
  • Year and Date: 2009-09-04
• [Presentation] ERE-GFPアッセイを用いた原発性乳癌のエストロゲン受容体転写活性解析と臨床病理学的因子との関連 (2009)
  • Author(s): 松本光代
  • Organizer: 第9回ホルモンと癌研究会
  • Place of Presentation: 岐阜・長良川国際会議場
  • Year and Date: 2009-06-20
• [Presentation] ERE-GFPアッセイによる原発性乳癌のエストロゲン受容体転写活性の解析と臨床病理学的因子との関連 (2009)
  • Author(s): 松本光代
  • Organizer: 第4回特定非営利活動法人東北内分泌研究会総会
  • Place of Presentation: 仙台・艮陵会館
  • Year and Date: 2009-04-26
• [Presentation] 子宮体癌間質細胞におけるエストロゲンを介した相互作用の解析 (2009)
  • Author(s): 松本光代
  • Organizer: 第60回日本産婦人科学会
  • Place of Presentation: 神奈川・パシフィコ横浜
  • Year and Date: 2009-04-15
• [Presentation] ヒト子宮体癌におけるエストロゲン刺激を介した癌-間質の相互作用の解析 (2008)
  • Author(s): 松本光代
  • Organizer: 第15回日本ステロイドホルモン学会学術集会
  • Place of Presentation: 仙台・艮陵会館
  • Year and Date: 2008-11-23
• [Presentation] Analysis of transcriptional activity of estrogen receptor by ERE-GFP assay in primary breast cancer and its clinical significance (2008)
  • Author(s): 松本光代
  • Organizer: 67^<th> Annual Meeting of the Japanease Cancer-Association
  • Place of Presentation: 愛知・名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] Expression of midkine in human endometrium and its disorder (2008)
  • Author(s): 田辺康次郎、松本光代
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2008-10-05
• [Presentation] Development of diagnosis and therapy for hormone-dependent cancers targeting nuclear receptor (2008)
  • Author(s): 林慎一、松本光代
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2008-10-05
• [Presentation] umor-stromal interaction through estrogen-signaling pathway analyzed by GFP assay in human endometrial cancer (2008)
  • Author(s): 松本光代
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2008-10-05
• [Presentation] 子宮体癌におけるエストロゲンシグナルを介した癌微小環境の解析 (2008)
  • Author(s): 松本光代
  • Organizer: 第8回ホルモンと癌研究会
  • Place of Presentation: 東京・品川プリンスホテル
  • Year and Date: 2008-07-27
• [Presentation] 子宮体癌間質細胞におけるエストロゲンを介した相互作用の解析 (2008)
  • Author(s): 松本光代
  • Organizer: 第60回日本産婦人科学会
  • Place of Presentation: 神奈川・パシフイコ横浜
  • Year and Date: 2008-04-15
• [Presentation] Tumor-stromal interaction through estrogen-signaling pathway analyzed by GFP assay in human endometrial cancer (2007)
  • Author(s): 松本光代
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] Development of diagnosis and therapy for hormone-dependent cancers targeting nuclear receptor (2007)
  • Author(s): 林 慎一
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] Expression of midkine in human endometrium and its disorder (2007)
  • Author(s): 田辺 康次郎
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] 子宮体癌の微小環境におけるエストロゲン受容体活性化の解析 (2007)
  • Author(s): 松本光代
  • Organizer: 第2回特定非営利活動法人東北内分泌研究会総会
  • Place of Presentation: 仙台・艮陵会館
  • Year and Date: 2007-04-28