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The clarification of drug-resistance and the development of new targeting therapies in ovarian cancer

Research Project

Project/Area Number 19791135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionYamagata University

Principal Investigator

OHTA Tsuyoshi  Yamagata University, 医学部, 助教 (50375341)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywords卵巣癌 / EGFR / gefitinib / Akt / ERK / DNA-PK / Gefitinib / DNA repair
Research Abstract

我々は、卵巣癌細胞においてEGF 受容体阻害剤であるgefitinib(イレッサ)が、CDDPが誘導するPI3K/AktやERK経路の活性化によるanti-apoptoticな作用を解除すること、さらにCDDPによるDNA損傷からの修復を阻害することによってCDDPの抗腫瘍効果を増強することをin vitro, in vivoで明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Fasudil-induced hypoxia-incucible factor 1-alp ha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine me chanism in endothelial cells2008

    • Author(s)
      高田恵子、太田剛、倉智博久
    • Journal Title

      Molecular cancer therapeutics 7(6)

      Pages: 1551-1561

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fasudil-induced hypoxia-incucible factor 1-alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells2008

    • Author(s)
      高田恵子
    • Journal Title

      Molecular cancer therapeutics 7(6)

      Pages: 1551-1561

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 卵巣癌細胞におけるGefitinibによるシスプラチンの抗腫瘍効果増強作用についての検討2008

    • Author(s)
      太田剛
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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