Clarification of relationship among Environmental stress, Placental construction and fetal growth, by analysis of autophagic cell death and apoptosis

• Project/Area Number: 19791139
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: NAKASHIMA Akitoshi University of Toyama, 大学院医学薬学研究部, 助教 (00436792)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 生殖医学 / 妊娠 / オートファジー / 胎盤 / 胎児 / 環境ストレス

Research Abstract

胎盤形成に重要な役割を果たす絨毛外栄養膜細胞が低酸素状態において母体への浸潤能が増加するが、その機能にオートファジーが大きく寄与することを世界に先駆けて初めて明らかにすることができた。

Research Products

• [Journal Article] Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion (2008)
  • Author(s): Nakashima A, Shiozaki A, Myojo S and Saito S, et. Al.
  • Journal Title: Am J Pathol. 173 Pages: 653-664
  • Peer Reviewed
• [Journal Article] Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells (2008)
  • Author(s): Hashimoto I, Koizumi K, Tatematsu M, Nakashima A, Saito S and Saiki I. et. Al.
  • Journal Title: Eur J Cancer 44 Pages: 1022-29
  • Peer Reviewed
• [Journal Article] The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy (2008)
  • Author(s): Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A.
  • Journal Title: J Reprod Immunol. 77 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion (2008)
  • Author(s): Akitoshi Nakashima
  • Journal Title: American journal of pathology 173 Pages: 653-664
  • Peer Reviewed
• [Journal Article] Inadequate tolerance induction may induce pre-eclampsia (2007)
  • Author(s): Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A.
  • Journal Title: J Reprod Immunol. 76 Pages: 30-9
  • Peer Reviewed
• [Journal Article] The role of the immune system in preeclampsia (2007)
  • Author(s): Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y.
  • Journal Title: Mol Aspects Med. 28 Pages: 192-209
  • Peer Reviewed
• [Journal Article] Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance (2007)
  • Author(s): Saito S, Shiozaki A, Sakai M, Nakashima A, Shima T, Ito M.
  • Journal Title: Semin Immunopathol. 29 Pages: 115-22
  • Peer Reviewed
• [Journal Article] What is the role of regulatory T cells in the success of implantation and early pregnancy? (2007)
  • Author(s): Saito S, Shima T, Nakashima A, Shiozaki A, Ito M, Sasaki Y.
  • Journal Title: J Assist Reprod Genet. Sep; 24(9) Pages: 379-86
  • Peer Reviewed
• [Journal Article] Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer (2007)
  • Author(s): Nakamura T, Shima T, Saeki A, Hidaka T, Nakashima A, Saito S, et. Al.
  • Journal Title: Cancer Sci. 98(6) Pages: 874-81
  • Peer Reviewed
• [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (2008)
  • Author(s): Tatematsu M, Nakashima A, Saito S.
  • Organizer: 13th IFPA meeting 2008
  • Place of Presentation: Seggau Castle, Austria
• [Presentation] オートファジーにより低酸素下、低栄養下の絨毛外栄養細胞の浸潤能は亢進する (Good presentation賞) (2008)
  • Author(s): 立松美樹子, 中島彰俊, 斎藤滋
  • Organizer: 第60回日本産科婦人科学会
  • Place of Presentation: 横浜
• [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (2008)
  • Author(s): 中島彰俊
  • Organizer: 第14回世界絨毛性疾患会議
  • Place of Presentation: 福岡
• [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (2008)
  • Author(s): 立松美樹子
  • Organizer: 14th IFPA/2nd PAA Conference
  • Place of Presentation: Austria, Seggau Castle
• [Presentation] オートファジーにより低酸素下、低栄養下の絨毛外栄養細胞の浸潤能は亢進する (2008)
  • Author(s): 立松美樹子
  • Organizer: 第60回日本産科婦人科学会
  • Place of Presentation: 横浜
• [Presentation] Autophagy, bulk degradation system, promotes extravilous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (2007)
  • Author(s): Tatematsu M, Nakashima A, Saito S.
  • Organizer: IFPA meeting 2007
  • Place of Presentation: Kingston, Canada
• [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (相馬賞) (2007)
  • Author(s): Nakashima A, Tatematsu M, Saito S.
  • Organizer: 第14回世界絨毛性疾患会議
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (2007)
  • Author(s): 中島 彰俊
  • Organizer: 第14回世界絨毛性疾患会議
  • Place of Presentation: 福岡
• [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (2007)
  • Author(s): 立松 美樹子
  • Organizer: 13th IFPA/2nd PAA Conference
  • Place of Presentation: Canada, Kingston