Elucidation and conquest of the taxane resistance based on cell cycle.

• Project/Area Number: 19791151
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Tottori University
• Principal Investigator: SATO Shinya Tottori University, 医学部附属病院, 助教 (10423261)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 婦人科腫瘍学 / 癌 / 細胞・組織 / 薬剤耐性 / 細胞周期

Research Abstract

(1)漿液性卵巣癌においてMEK経路とPI3/Akt経路の同時阻害は相乗的な抗腫瘍効果を示し、パクリタキセル感受性増強の可能性が示唆された。
(2)5-FUとオキサリプラチンとの併用療法は、粘液性腺癌に対する有効な治療法の一つと考えられた。

Research Products

• [Journal Article] Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary : apotential treatment strategy. (2009)
  • Author(s): Sato S,Itamochi H,Kigawa J,Oishi T,Shimada M,Sato S,Nainiwa J,Uegaki K,Nonaka M,Terakawa N
  • Journal Title: Cancer Science 100(3) Pages: 545-551
  • Peer Reviewed
• [Journal Article] 難治性卵巣癌に対する治療の個別化。 (2009)
  • Author(s): 板持広明、野中道子、佐藤誠也、浪花潤、上垣憲雅、佐藤慎也、島田宗昭、紀川純三
  • Journal Title: 日本婦人科腫瘍学会雑誌 27(1) Pages: 32-36
  • NAID: 10025202730
• [Journal Article] Combination chemotherapy of oxaliplatin and 5-fluorou racil may be an effecitive regimen for mucinous adeno carcinoma of the ovary : a potential treatment strategy (2009)
  • Author(s): Seiya Sato
  • Journal Title: Cancer Science 100(3) Pages: 546-551
  • Peer Reviewed
• [Journal Article] 卵巣癌の腹腔内抗癌剤投与法 (2008)
  • Author(s): 佐藤慎也、板持広明、紀川純三
  • Journal Title: 臨床婦人科産科 62(10) Pages: 1316-1319
• [Journal Article] Chemotherapy consisting ofpaclitaxel and carboplatin benefits a patient with malignant mixed mullerian tumor of the fallopian tube. (2008)
  • Author(s): Kawaguchi W,Itamochi H,Kigawa J,Kanamori Y,Oishi T,Shimada M,Sato S,Sato S,Terakawa N
  • Journal Title: International Journal of Clinical Oncology 13(5) Pages: 461-463
  • Peer Reviewed
• [Journal Article] 抗癌剤低感受性卵巣癌に対する治療戦略 (2008)
  • Author(s): 板持広明、野中道子、佐藤誠也、浪花潤、佐藤慎也、島田宗昭、紀川純三、寺川直樹
  • Journal Title: 日本婦人科腫瘍学会雑誌 26(3) Pages: 367-372
  • NAID: 10021237585
• [Journal Article] (2008)
  • Author(s): Shimogai R,Kigawa J,Itamochi H,Iba T.Kanamori Y.Oishi T.Shimada M,Sato S,Kawaguchi W,Sato S
  • Journal Title: Int J Gynecol Cancer 18(3) Pages: 499-505
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions : initial results. (2008)
  • Author(s): Fujii S.Matsusue E,Kigawa J,Sato S,Kanasaki Y,Nakanishi J,Sugihara S,Kaminou T,Terakawa N,Ogawa T
  • Journal Title: Eur Radiol 18(2) Pages: 384-389
  • Peer Reviewed
• [Journal Article] Chemotherapy consisting of paclitaxel and carboplatin benefits a patient with malignant mixed mullerian tumor of the fallopian tube (2008)
  • Author(s): Wakae Kawaguchi
  • Journal Title: International Journal of Clinical Onco logy 13(5) Pages: 461-463
  • Peer Reviewed
• [Journal Article] Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3'-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma. (2007)
  • Author(s): Kawaguchi W,Itamochi H,Kigawa J,Kanamori Y,Oishi T,Shimada S,Sato S,Shimogai R, Sato S,Terakawa N
  • Journal Title: Cancer Science 98(12) Pages: 2002-2008
  • NAID: 10019996817
  • Peer Reviewed
• [Journal Article] Galectin-3 may contribute to Cisplatin resistance in clear cell carcinoma of the ovary. (2007)
  • Author(s): Oishi T,Itamochi H,Kigawa J,Kanamori Y,Shinamda M,Takahashi M,Shimogai R,Kawaguchi W,Sato S,Terakawa N.
  • Journal Title: International Journal of Gynecologic Cancer 17(5) Pages: 1040-1046
  • Peer Reviewed
• [Journal Article] 卵巣明細胞腺癌におけるGalectin-3発現とCDDP感受性。 (2007)
  • Author(s): 大石徹郎、佐藤誠也、川口稚恵、佐藤慎也、島田宗昭、板持広明、金森康展、紀川純三、寺川直樹
  • Journal Title: 日本婦人科腫瘍学会雑誌 25(1) Pages: 39-43
  • NAID: 10026152688
• [Journal Article] Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositoI 3'-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma. (2007)
  • Author(s): Kawaguchi Wakae.
  • Journal Title: Cancer Science 98 Pages: 2002-2008
  • Peer Reviewed
• [Journal Article] Galectin-3 may contribute to Cisplatin resistance in clear cell carcinoma of the ovary. (2007)
  • Author(s): Oishi Tetsuro
  • Journal Title: Int J Gynecol Cancer 17 Pages: 1040-1046
  • Peer Reviewed
• [Presentation] Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary : A potential treatment strategy. (2009)
  • Author(s): Sato S,Itamochi H,Kigawa J,Oishi T,Shimada M,Sato S,Nainiwa J,Uegaki K,Nonaka M,Terakawa N
  • Organizer: 100th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Denver
• [Presentation] 卵巣粘液性腺癌の至適化学療法に関する基礎的検討 (2008)
  • Author(s): 佐藤誠也、板持広明、野中道子、上垣憲雅、浪花潤、佐藤慎也、島田宗昭、大石徹郎、紀川純三、寺川直樹
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] Effect of simultaneous inhibition of MEK and PI3K/Akt pathways on paclitaxel sensitivity in ovarian cancer. (2007)
  • Author(s): Kawaguchi W,Itamochi H,Kigawa J,Kanamori Y,Oishi T,Shimada S,Sato S,Shimogai R, Sato S,Terakawa N
  • Organizer: 43rd Annual Meeting of the American Society of Clinical Oncology
  • Place of Presentation: Chicago