Digital Karyotyping in ovarian clear cell carcinoma
| Project/Area Number |
19791152
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shimane University |
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Principal Investigator |
NAKAYAMA Kentaro Shimane University, 医学部, 講師 (70346401)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,540,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | 癌 / ゲノム / 卵巣癌 / 分子標的 |
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| Research Abstract |
Disital Karyotyping (DK)、Serial Analysis Gene Expression(SAGE)を用いて網羅的な遺伝子発現解析を行い、卵巣癌特有の遺伝子変化を同定し、卵巣癌の治療を目指した分子標的を同定する事を目的とした。近年、造血器腫瘍を中心に癌遺伝子の機能がクローズアップされているBTB/POZ遺伝子群に注目した。BTB/POZ遺伝子群の中でNAC-1遺伝子が有意に高発現している事を発見した。NAC-1は再発卵巣癌でタンパク、遺伝子発現共に有意に高かった。また、in vitoro, in vivoの両方でNAC-1はOncogenicな機能を有する事を発見した。
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] A BTB/POZ protein, NAC-1, a tumor recurrence associated gene, as a potential target for taxol resistance in ovarian cancer.2008
Author(s)
Ishibashi M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N, Fukumoto M, Miyazaki K
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Journal Title
Clin Cancer Res. 14(10)
Pages: 3149-55
Related Report
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[Journal Article] Genetic classification of ovarian carcinoma based on microsatellite analysis : relationship to clinicopathological features and patient survival.2008
Author(s)
Huan Z, Nakayama K, Nakayama N, Ishibashi M, Yeasmin S, Katagiri A, Purwana IN, Iida K, Maruyama R, Fukumoto M, Miyazaki K
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Journal Title
Oncol Rep. 19(3)
Pages: 775-81
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