Analysis for molecular mechanism of glycodelin regulating human endometrial epithelial cell growth
Project/Area Number |
19791165
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
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Research Institution | Keio University |
Principal Investigator |
OHTA Kuniaki Keio University, 医学部, 共同研究員 (90424142)
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Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
|
Keywords | 子宮内膜 / グリコデリン / 子宮内膜症 / 子宮体癌 / 細胞増殖 / 子宮内膜腺上皮 / 着床 |
Research Abstract |
着床関連タンパクGlycodelinは、細胞回転調節因子であるp16、p21、p27の発現増加を介して細胞回転のG1/S停止を引き起こすことで、子宮内膜腺上皮細胞の細胞増殖を負に制御している。これらの結果は、子宮内膜増殖症や子宮体癌などの子宮内膜腺上皮細胞の増殖性疾患に対して、従来の増殖規定因子である性ホルモンによる生殖内分泌学的な治療アプローチとは独立して、Glycodelinを分子標的とした新しい治療戦略展開の分子基盤研究となった。
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割2008
Author(s)
小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 各務真紀, 小田英之, 西川明花, 升田博隆, 長島隆, 太田邦明, 伊藤守, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
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Journal Title
日本生殖内分泌学会雑誌 13
Pages: 25-29
NAID
Related Report
Peer Reviewed
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[Journal Article] Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells2007
Author(s)
Ono M, Maruyama T*, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H,Asada H, Yoshimura Y, Okano H, Matsuzaki Y
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Journal Title
Proc Natl Acad Sci USA 104(47)
Pages: 18700-18705
Related Report
Peer Reviewed
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[Presentation] OCT‐4 expression in human myometrium2007
Author(s)
Masanori Ono, Tetsuo Maruyama, Takashi Kajitani, Hiroshi Uchida, Hirotaka Masuda, Takashi Nagashima, Toru Arase, Kuniaki Ohta, Hironori Asada, Yasunori Yoshimura
Organizer
AOCOG2007
Place of Presentation
Tokyo,Japan
Related Report
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[Presentation] Reconstruction and in vivo bioluminescence imaging of human endometrium in immunodeficient mice : its potential application as an endometriosis model2007
Author(s)
Hirotaka Masuda, Tetsuo Maruyama, Takashi Nagashima, Masanori Ono, Takashi Kajitani, Kuniaki Ohta, Toru Arase, Maki Kagami, Hironori Asada, Hideyuki Okano, Yumi Matsuzaki, Yasunori Yoshimura
Organizer
23th Annual Meeting of the ESHRE
Place of Presentation
Lyon,France
Related Report
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[Presentation] Src kinase activity is essential for decidualization of human endometrial stromal cells2007
Author(s)
Takashi Nagashima, Maruyama, Hiroshi Uchida, Takashi Nagashima, Masanori Ono, Toru Arase, Maki Kagami, Kuniaki Ohta, Hironori Asada, Yasunori Yoshimura
Organizer
23th Annual Meeting of the ESHRE
Place of Presentation
Lyon, France
Related Report