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Functional and expressional analysis of EBV latent membrane protein-1 (LMP-1) in nasal NK/T-cell lymphoma

Research Project

Project/Area Number 19791180
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

TAKAHARA Miki  Asahikawa Medical College, 医学部, 助教 (50322904)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords鼻性NK / T細胞リンパ腫 / LMP1(latent membrane protein 1) / Estein-Barr virus (EBV) / Latent Membrane protein 1 (LMP1) / サイトカイン / 単球 / 膜性IL-15 / IP-10 / Epstein-Barr virus (EBV) / IL-10 / CD25
Research Abstract

鼻性NK/T細胞リンパ腫は非常に予後が悪いEBV発癌リンパ腫である。LMP1はEBV由来蛋白であり、本腫瘍における調節、機能は不明である。本腫瘍細胞株でのLMP1の発現調節を検討したところ、IL.2, 10, 15, IFN-gammaの細胞外刺激がLMP1の発現を増強させた。また、その増強したLMP1がCD25やIP-10を介して細胞増殖や遊走能を亢進させた。従って、LMP1は本リンパ腫にて腫瘍増殖、転移に関与している可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (35 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Book (6 results)

  • [Journal Article] 耳鼻咽喉科処置の有用性 口腔咽頭に生じる潰瘍性病変に対する保存的治療とベーチェット病に対する扁桃摘出術の有効性2009

    • Author(s)
      高原幹、原渕保明
    • Journal Title

      耳鼻臨床 102

      Pages: 240-241

    • Related Report
      2008 Final Research Report
  • [Journal Article] 口腔・咽頭科診療における論点 掌蹠膿疱症における扁桃摘出術の適応をどう考えるか? -耳鼻咽喉科の立場から-2008

    • Author(s)
      吉崎智貴、高原幹、坂東伸幸、原渕保明
    • Journal Title

      JHONS 24

      Pages: 1557-1561

    • Related Report
      2008 Final Research Report
  • [Journal Article] 口腔内病変をどう診るか 鑑別を要する病態、口腔潰瘍2008

    • Author(s)
      原渕保明、高原幹
    • Journal Title

      JHONS 23

      Pages: 1831-1835

    • Related Report
      2008 Final Research Report
  • [Journal Article] Esteban Celis. Induction of EBV.Latent Membrane Protein 1.Specific MHC Class II.Restricted T- Cell Responses against Natural Killer Lymphoma Cells2008

    • Author(s)
      Kobayashi H, Nagato T, Takahara M, Sato K, Kimura S, Aoki N, Azumi K, Tateno M, Harabuchi Y
    • Journal Title

      Cancer Res 68

      Pages: 901-908

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Esteban Celis. Induction of EBV-Latent Membrane Protein 1-Specific MHC Class II-Restricted T-Cell Responses against Natural Killer Lymphoma Cells2008

    • Author(s)
      Kobayashi H, Nagato T, Takahara M
    • Journal Title

      Cancer Res 68

      Pages: 901-908

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective expansion of TCR V beta 6 in tonsillar T-cells induced by H. parainfluenzae in patients with IgA nephropathy2008

    • Author(s)
      Nozawa H, Takahara M, Yoshizaki T, Goto T, Bandoh N, Harabuchi Y
    • Journal Title

      Clinical and Experimental Immunology 151

      Pages: 25-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鼻性NK/T細胞リンパ腫細胞株SNK6におけるLEA-1とICAM1の機能解析2008

    • Author(s)
      高原幹, 岸部幹, 森合重誉, 坂東伸幸, 荻野武, 原渕保明
    • Journal Title

      耳鼻咽喉科免疫アレルギー 26

      Pages: 104-105

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 鼻性NKIT細胞リンパ腫におけるIP-10の発現と機能2008

    • Author(s)
      森合重誉, 高原幹, 長門利純, 岸部幹, 荻野武, 原渕保明
    • Journal Title

      耳鼻咽喉科免疫アレルギー 26

      Pages: 102-103

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 鼻性NK/T細胞リンパ腫に対する浅側頭動脈動注化学放射線同時併用療法2007

    • Author(s)
      高原幹、荻野武、原渕保明
    • Journal Title

      耳鼻と臨床 53

      Pages: 57-63

    • NAID

      130004405104

    • Related Report
      2008 Final Research Report
  • [Journal Article] 扁桃病巣疾患の臨床と病態2007

    • Author(s)
      原渕保明、高原幹、坂東伸幸、岸部幹、後藤孝、野澤はやぶさ、吉崎智貴、上田征吾
    • Journal Title

      耳鼻咽喉科展望 50

      Pages: 10-19

    • NAID

      130003795458

    • Related Report
      2008 Final Research Report
  • [Journal Article] Selective expansion of TCR V beta 6 in tonsillar T-cells induced by H. parainfluenzae in patients with IgA nephropathy2007

    • Author(s)
      Nozawa H, Takahara M, Yoshizaki T, Goto T, Bandoh N, Harabuchi Y
    • Journal Title

      Clinical and Experimental Immunology 151

      Pages: 319-322

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma2007

    • Author(s)
      Nagamine M, Takahara M, Kishibe K, Nagato T, Ishii H, Bandoh N, Ogino T, Harabuchi Y
    • Journal Title

      Virus Genes 34

      Pages: 47-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selected Amino Acid Change Encoding Epstein-Barr Virus-Specific T Cell Epitope of the LMP2A Gene in Japanese Nasal NK/T Cell Lymphoma Patients2007

    • Author(s)
      Nagamine M, Kishibe K, Takahara M, Nagato T, Ishii H, Bandoh N, Ogino T, Harabuchi Y
    • Journal Title

      Intervirology 50

      Pages: 319-322

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 鼻性NK/T細胞リンパ腫に対する浅側頭動脈動注化学放射線同時併用療法2007

    • Author(s)
      高原 幹
    • Journal Title

      耳鼻と臨床 53

      Pages: 57-63

    • NAID

      130004405104

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selected Amino Acid Change Encoding Epstein-Barr Virus-Specific T Cell Epitope of the LMP2A Gene in Japanese Nasal NK/T Cell Lymphoma patients.2007

    • Author(s)
      Nagamine, M.
    • Journal Title

      Intervirology 50

      Pages: 319-322

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma.2007

    • Author(s)
      Nagamine, M.
    • Journal Title

      Virus Genes 34

      Pages: 47-54

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 当科における鼻性NK/T細胞リンパ腫の診断と治療2008

    • Author(s)
      高原幹、原渕保明
    • Organizer
      厚生労働省「NK細胞腫瘍に対する東アジア多国間治療研究」班会議
    • Place of Presentation
      名古屋
    • Year and Date
      2008-12-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression and fUnction of LEA-1 and ICAM-1 in nasal NKIT cell lymphoma2008

    • Author(s)
      Takahara M, Kishibe K,Moriai S, Ishii H, Harabuchi Y
    • Organizer
      The 13th EBV Symposium 2008
    • Place of Presentation
      Guangzhou, China
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Autocrine function of inter feron-gamma-inducible protein-10 (IP-10) in nasal NK/T cell lymphoma2008

    • Author(s)
      Moriai S, Takahara M, Nagato T, Kishibe K, Harabuchi Y
    • Organizer
      The 13th EBV Syposium2008
    • Place of Presentation
      Guangzhou, Chiha
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Co-culture with monocytese enhanced the expression of LMP-1 in cell lines dehved from EBV positive NK malignancies2008

    • Author(s)
      Ishii H, Takahara M, Harabuchi Y ,Klein E
    • Organizer
      The 13th EBV Symposium 2008
    • Place of Presentation
      Guangzhou, China
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] New treatment and monitorillg procedures for nasal NK/T-cell lymphoma : intra-maxillary arterial chemotherapy and analysis of serum EBV DNA2008

    • Author(s)
      Takahara M, IshiiH, OginoT, Harabuchi Y
    • Organizer
      The 12th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-10 leads to elevated expression of CD25 on SNK6 through the EBV encoded latent membrane protein 1 (LMP1)2008

    • Author(s)
      Takahara M, Nagato T, Kishibe K, Harabuch Y.
    • Organizer
      9^<th> Japan-Taiwan Conference in Oto-Rhino-Laryngology, Head and Neck Surgery
    • Place of Presentation
      Sendai,Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression and function of LFA-1 and ICAM-1 in nasal NK/T cell lymphoma2008

    • Author(s)
      Takahara M, Kishibe K, Moriai S, Ishii H, Harabuchi Y
    • Organizer
      The 13th Biennial Conference of the International Association for Research on EBV and Associated Disease (the EBV 2008 Conference)
    • Place of Presentation
      Guangzhou China
    • Related Report
      2008 Final Research Report
  • [Presentation] 鼻性NK/T細胞リンパ腫細胞株SNK6におけるIL-10によるLMP1を介したCD25の発現上昇2008

    • Author(s)
      高原幹、長門利純、岸部幹、森合重誉、片山昭公、原渕保明
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 鼻性NK/T細胞リンパ腫細胞株における可溶性ICAM1の解析2008

    • Author(s)
      高原幹、岸部幹、森合重誉、石井秀幸、片山昭広、林達哉、原渕保明
    • Organizer
      第32回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 鼻性NK/T細胞リンパ腫細胞株SNK6におけるLFA-1とICAM1の発現2008

    • Author(s)
      高原幹、長門利純、岸部幹、森合重誉、坂東伸幸、荻野武、林達也、原渕保明
    • Organizer
      第108回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] New treatment and monitoring procedures for nasal NK/T-cell lymphoma: intra- maxillary arterial chemotherapy and analysis of serum EBV DNA2008

    • Author(s)
      Takahar M, Ishii H, Ogino T, Harabuchi Y
    • Organizer
      The 12th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Nara Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] 鼻性NK/T細胞リンパ腫細胞株SNK6におけるLFA-1とICAM1の機能解析2008

    • Author(s)
      高原幹、岸部幹、森合重誉、坂東伸幸、原渕保明
    • Organizer
      第26回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-10 leads to elevated expression of CD25 on SNK6 through the EBV encoded latent membrane protein 1 (LMP1)2007

    • Author(s)
      Takahara, M.
    • Organizer
      Japan-Taiwan Conference in Oto-Rhino-Laryngology, Head and Neck Surgery
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Book] 耳鼻咽喉科ウイルス感染症(氷見徹夫編) EBウイルス感染と頭頸部腫瘍、MB-ENT 992009

    • Author(s)
      高原幹、原渕保明
    • Related Report
      2008 Final Research Report
  • [Book] MB-ENT2009

    • Author(s)
      高原幹、原渕保明
    • Total Pages
      8
    • Publisher
      耳鼻咽喉科ウイルス感染症(氷見徹夫編)EBウイルス感染と頭頸部腫瘍
    • Related Report
      2008 Annual Research Report
  • [Book] EBウイルス(高田賢蔵編) 鼻性NK/T細胞リンパ腫2008

    • Author(s)
      原渕保明、高原幹
    • Publisher
      診断と治療社(東京)
    • Related Report
      2008 Final Research Report
  • [Book] EBウイルス(高田賢蔵編)鼻性NK/T細胞リンパ腫2008

    • Author(s)
      原渕保明、高原幹
    • Total Pages
      10
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Book] 潜伏感染ウイルスによる血液疾患 新しい診断と治療のABC EBウイルスとT/NK細胞増殖症(河敬世編):(6)鼻性NK/T細胞リンパ腫.発見の契機2007

    • Author(s)
      原渕保明、高原幹
    • Publisher
      最新医学社(大阪)
    • Related Report
      2008 Final Research Report
  • [Book] 潜伏感染ウイルスによる血液疾患 新しい診断と治療のABC2007

    • Author(s)
      原渕保明
    • Total Pages
      10
    • Publisher
      最新医学社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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