Function of thymidylate synthase as a therapeutic target in head and neck cancer

• Project/Area Number: 19791182
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: International University of Health and Welfare (2008); Hirosaki University (2007)
• Principal Investigator: MARUYA Shinichiro International University of Health and Welfare, 大学病院, 講師 (90396408)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: 頭頸部癌 / 腺様嚢胞癌 / thymidylate synthase / thymidilate synthase / siRNA / アポトーシス / apoptosis / 頭頸部扁平上皮癌

Research Abstract

頭頸部癌細胞においてthymidylate synthaseの発現抑制が癌細胞の増殖を有意に抑制することが明らかとなった。

Research Products

• [Journal Article] Differential expression of topoisomerase IIα protein in salivary gland carcinomas: histogenetic and prognostic implications. (2009)
  • Author(s): Maruya S, Shirasaki T, Nagaki T, Kakehata S, Kurotaki H, Mizukami H, Shinkawa H.
  • Journal Title: BMC Cancer (in press)
• [Journal Article] Differential expression of topoisometase IIα protein in salivary carcinomas : histogenetic and prognostic implications (2009)
  • Author(s): Maruya S, Shirasaki T, Nagaki T, Kakehata S, Kurotaki H, et.al.
  • Journal Title: BMC Cancer (In press)(印刷中)
  • Peer Reviewed
• [Journal Article] Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma. (2008)
  • Author(s): Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H.
  • Journal Title: BMC Cancer (in press)
• [Journal Article] Autologous serum eardrops therapy with a chitin membrane for closing tympanic membrane perforations (2008)
  • Author(s): Kakehata S, Hirose Y, Kitani R, Futai K, Maruya S, Ishii K, Shinkawa H.
  • Journal Title: Otol Neurotol 29 Pages: 791-795
• [Journal Article] Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma (2008)
  • Author(s): Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, et.al.
  • Journal Title: BMC Cancer (In press)(印刷中)
  • Peer Reviewed
• [Journal Article] Autologous serum eardrops therapy with a chitin membrane for closing tympanic membrane for closing tympanic membrane perforations (2008)
  • Author(s): Kakehata S, Hirose Y, Kitani R, Futai K Maruya S, Ishii K, Shinkawa H
  • Journal Title: Otol Neurotol 29 Pages: 791-795
  • Peer Reviewed
• [Journal Article] Simvastatin inactivates β1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. (2007)
  • Author(s): Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H.
  • Journal Title: Cancer Sci 98 Pages: 890-899
• [Journal Article] Developmental expression of the outer hair cell moter prestin in the mouse (2007)
  • Author(s): Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H.
  • Journal Title: L Membr Biol 215 Pages: 49-56
• [Journal Article] Simvastatin inactivates β1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells (2007)
  • Author(s): Takeda I, Maruya S, et. al.
  • Journal Title: Cancer Science 98 Pages: 890-899
  • Peer Reviewed
• [Presentation] 頭頸部癌における遺残例、再発・転移例に対するTS-1の使用経験 (2007)
  • Author(s): 白崎隆、丸屋信一郎, 他
  • Organizer: 第45回日本癌治療学会
  • Place of Presentation: 京都国際会議場