New drug delivery into inner ear ; possibility of the treatment withnano technology

• Project/Area Number: 19791184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: YAMAUCHI Daisuke Tohoku University, 大学院・医学系研究科, 非常勤講師 (70361102)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 耳鼻咽喉科学 / ナノバイオ / nano particle(Qdot) / drug delivery system / inner ear / cochlear nucleus / nano particle (Qdot)

Research Abstract

Nano particle was examined for the potential of drug delivery to inner ear. Qdot 655 was conjugated respectively with several peptides which are horseradish peroxidase(HRP), Galectin-1, L-Glutamin Acid and epidermal growth factor(EGF). When Qdot was injected into scala media of the cochlea in guinea pig, Qdots with Galectin 1 and EGF were introduced into organ of Corti and Reissner's membrane. Nano particle is expected as treatment for inner ear disease.