New drug developments using RNA interference for allergic rhinitis
| Project/Area Number |
19791200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
ENDO Shuichiro University of Yamanashi, 医学部附属病院, 助教 (20324204)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | スギ花粉症 / RNA干渉 / 制御性T細胞 / Cry j 1 / Th2細胞 / Cry j1T細胞エピトープ / T細胞クローン |
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| Research Abstract |
Allergic rhinitis has been defined as the inadequate peripheral regulation of allergen-specific T cells in individuals. In this study, we investigated the suppressive effect of RNA interference to allergen-specific Th responses and regulatory T cell responses in patients with allergic rhinitis. The suppressive effect to allergen-specific Th2 responses and regulatory T cell responses by RNA interference was not sufficient. On the other hand, our findings showed that regulatory T cells predominantly suppressed Th1 responses rather than Th2 responses, where allergen-specific IL-10-producing regulatory T cells might be responsible for the down-regulation of allergen-specific responses.
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Report
(4 results)
Research Products
(16 results)
