Identification and differentiation induction of M cell in human nasal epithelial cells: a unique and new target for DDS
Project/Area Number |
19791218
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Sapporo Medical University |
Principal Investigator |
GO Mitsuru Sapporo Medical University, 医学部, 助教 (80448604)
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Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
|
Keywords | 耳鼻咽喉学 / アレルギー / 病理学 / タイト結合 / 鼻粘膜 |
Research Abstract |
ヒト咽頭扁桃(adenoid)上皮は,発達したタイト結合による上皮バリア機能を有し,外来病原体に対する生体防御の役割を担っていることが考えられる.そこで,我々はcytokeratin 20 (Ck20)をマーカーとして,ヒト咽頭扁桃(adenoid)におけるM細胞の同定をし,in vivoおよびin vitroでのタイト結合蛋白の発現を調べた.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] PKC enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008
Author(s)
Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
Author(s)
Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N.
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Journal Title
J Mol Histol. 39(3)
Pages: 265-273
Related Report
Peer Reviewed
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