The development of controlled-release antibiotics by use of DDS against intractable bacterial infections

• Project/Area Number: 19791224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Wakayama Medical University
• Principal Investigator: SUZUMOTO Masaki Wakayama Medical University, 医学部, 助教 (20382327)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,600,000)
• Keywords: 急性中耳炎 / DDS / 肺炎球菌 / インフルエンザ菌 / 副鼻腔炎

Research Abstract

抗菌薬のシリコン除法製剤およびゲル除法製剤を作成してその有効性につき検討を行った.カルバペネム系抗菌薬であるメロペネムを充填したシリコン徐放製剤を作成し、チンチラを用いたインフルエンザ菌実験的中耳炎モデルにて検討した.またレボフロキサシン(LVFX)ゲル徐放製剤を作成し同様の方法で、その有効性についての検討を行った.メロペネム・シリコン徐放製剤群では、治療開始6日後にはすべてのチンチラでインフルエンザ菌が除菌されていた.LVFXゲル徐放製剤注入群では3例中2個体で5日目にはインフルエンザ菌が除菌された.

Research Products

• [Journal Article] Efficacy of a novel oral carbapenem, tebipenem pivoxil (TBM-PI) (2007)
  • Author(s): Hotomi M, Suzumoto M, Itahashi K, Nagura J, Fukushima T, Shimada J, Billal DS,Yamauchi K, Fujihara K, Yamanaka N
  • Journal Title: against experimental otitis media caused by penicillin resistant Streptococcus pneumoniae in chinchilla ; Vaccine Mar22 25(13) Pages: 2478-84
  • Peer Reviewed
• [Journal Article] Efficacy of a novel oral carbapenem, tebipenem pivoxil (TBM-PI),against experimental otitis media caused by penicllin resistant Streptococcus pneumoniae in chinchilla (2007)
  • Author(s): Hotomi M, Suzumoto M, Itahashi K, Nagura J, Fukushima T, Shimada J, Bfflal DS, Yamauchi K, Fujihara K, Yamanaka N.
  • Journal Title: Vaccine Mar22;25(13) Pages: 2478-2484
  • Peer Reviewed