Cytotoxic T lymphcytes induced by SCCA derived peptides

• Project/Area Number: 19791246
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kurume University
• Principal Investigator: ONO Takeharu Kurume University, 医学部, 助教 (70449916)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,170,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 免疫学 / 癌 / CTL / ペプチド / SCCA

Research Abstract

頭頸部癌患者の抗ペプチド抗体価(IgA,IgG)は健常人と比較して高い傾向であることがわかった。抗体価の高い患者の末梢血単核球をSCCAペプチドで刺激するとCTL誘導能が優れていることがわかった。

Research Products

• [Journal Article] Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours (2009)
  • Author(s): Sakamoto K, Ono T, Nakamura Y,Harada H, Nakashima T.
  • Journal Title: J Laryngol Otol 31 Pages: 58-63
• [Journal Article] Selective (intra-arterial), rapid infusion chemo-radiotherapy to preserve the larynx in advanced laryngeal carcinoma: preliminary results. (2009)
  • Author(s): Nakashima T, Mihoki T, Ono T, Umeno H, Tanaka N.
  • Journal Title: J Laryngol Otol 31 Pages: 30-34
• [Journal Article] A correlation between symptom severity and unbalanced reactive IgA production in Japanese cedar pollinosis patients (2009)
  • Author(s): Komatsu N, Harada M, Nakagawa M, Tanaka Y, Ono T, Gohara S, Ohkubo K, Itoh K.
  • Journal Title: Asian Pac J Allergy Immunol 26(2-3) Pages: 97-104
• [Journal Article] Brain surface spindle cell glioma in a patient with medically intractable partial epilepsy: a variant of monomorphous angiocentric glioma (2008)
  • Author(s): Sugita Y, Ono T, Ohshima K, Niino D, Ito M, Toda K, Baba H.
  • Journal Title: Neuropathology 8(5) Pages: 516-520
• [Journal Article] Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients (2007)
  • Author(s): Takao Y, Yamada A, Yutani S, Ono T, Nagao Y, Ando E, Ide T, Itoh K, Sata M.
  • Journal Title: Med Microbiol Immunol 196(3) Pages: 157-164
• [Journal Article] Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b with the potentiality to generate cytotoxic T lymphocytes in HCV1b(+) HLA-A24(+) patients (2007)
  • Author(s): Takao Y, Yamada A, Yutani S, Takedatsu H, Ono T, Etoh K, Wang Y, Suzuki S, Ide T, Shimotohno K, Sata M, Itoh K.
  • Journal Title: Hepatol Res 37(3) Pages: 186-195
  • NAID: 10020164621
• [Presentation] Cytotoxic T lymphocytes induced by HSCC Ag derived peptides. (2008)
  • Organizer: アメリカ耳鼻咽喉科学会,シカゴ
  • Place of Presentation: アメリカ
• [Presentation] Cytotoxic T lymphcytes induced by SCCA derived peptides (2008)
  • Author(s): 小野剛治
  • Organizer: アメリカ耳鼻咽喉科学会
  • Place of Presentation: シカゴ