Molecular pathological study of presbycusis, focused on the lateral wall of cochlea
| Project/Area Number |
19791250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
KIMURA Yurika Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員 (40450564)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,942,106 (Direct Cost: ¥4,101,620、Indirect Cost: ¥840,486)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,172,106 (Direct Cost: ¥901,620、Indirect Cost: ¥270,486)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 老人性難聴 / 遺伝性難聴 / ヒト側頭骨病理学 / 感音性難聴 / TaqMan PCR / 蝸牛 / mRNA / 加齢 / 感音難聴 / ヒト側頭骨病理 / レーザーマイクロダイゼクション法 / 血管条 / ラセン靱帯 / ラセン靭帶 / Taq Man PCR |
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| Research Abstract |
We have tried to introduce molecular biological techniques to human temporal bone pathology, such as mRNA analysis from frozen human cochlea, the immunohistological examination of paraffin embedding human inner ear and identification of local gene expression in human cochlea by lasermicrodissection. We pointed out the possibility of contribution of inner ear specific protein cochlin to presbycusis in the cochlear lateral wall.
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Report
(5 results)
Research Products
(28 results)
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[Book] めまい
Author(s)
木村百合香, 高橋正時, 喜多村健
Publisher
老年医学の基礎と臨床I
Related Report
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