Neuroprotective treatment for glaucoma

• Project/Area Number: 19791255
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Tohoku University
• Principal Investigator: NAKAZAWA Toru Tohoku University, 病院, 講師 (30361075)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: 緑内障 / 炎症 / マウス / 神経保護治療 / サイトカイン / マイクログリア / 網膜神経節細胞 / オリゴデンドロサイト

Research Abstract

緑内障は中途失明疾患の第一位であり、現状では眼圧下降がもっとも重要な治療法であるが、眼圧低下治療以外の新規の神経保護治療の確立が必要である。TNFαは炎症を惹起する炎症性サイトカインで、多くの中枢神経疾患において、その神経毒性が報告されている。そこで本研究ではマウス眼圧上昇モデルを作製し、TNFα抑制が新規の緑内障治療になり得るのかを検討した。こうして、TNFαの抑制およびマイクログリアの抑制は緑内障の新規神経保護治療の候補として重要である可能性が示唆された。

Research Products

• [Journal Article] Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis. (2008)
  • Author(s): Noda K, Miyahara S, Nakazawa T, 他, 11名
  • Journal Title: FASEB J. 22 Pages: 1094-1103
  • Peer Reviewed
• [Journal Article] Self-protective roles of Muller cells during NMDA-induced retinal damage through activation of ERK signaling pathway. (2008)
  • Author(s): Nakazawa T, 他, 6名
  • Journal Title: J Neurosci Res. 86 Pages: 136-144
  • Peer Reviewed
• [Journal Article] Dexamethasone Reduces Photoreceptor Damage Caused by Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. (2008)
  • Author(s): She H, Nakazawa T, 他, 7名
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 5008-5014
  • Peer Reviewed
• [Journal Article] Vascular Adhesion Protein-1 Blockade Suppresses Choroidal Neovascularization. (2008)
  • Author(s): Noda K, She H, Nakazawa T, 他, 12名
  • Journal Title: FASEB J. 22 Pages: 2928-2935
  • Peer Reviewed
• [Journal Article] A Novel mechanism of HIV protease inhibitors for neuroprotection through inhibition of mitochondrial apoptosis. (2008)
  • Author(s): Hisatomi T, Nakazawa T, 他, 13名
  • Journal Title: J Clin Invest. 118 Pages: 2025-2038
  • Peer Reviewed
• [Journal Article] Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells. (2008)
  • Author(s): Nakazawa T, 他, 7名
  • Journal Title: J Neurosci Res. 87 Pages: 1412-1423
  • Peer Reviewed
• [Journal Article] Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis (2008)
  • Author(s): Noda K, Miyahara S, Nakazawa T, et.al.
  • Journal Title: FASEB J 22 Pages: 1094-1103
  • Peer Reviewed
• [Journal Article] Self-protective roles of Muller cells during NMDA-induced retinal damage through activation of ERK signaling pathway (2008)
  • Author(s): Nakazawa T, et.al.
  • Journal Title: J Neurosci Res. 86 Pages: 136-144
  • Peer Reviewed
• [Journal Article] Dexamethasone Reduces Photoreceptor Damage Caused by Photodynami c Therapy in a Rat Model of Choroidal Neovascularization (2008)
  • Author(s): She H, Nakazawa T, et.al.
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 5008-5014
  • Peer Reviewed
• [Journal Article] Vascular Adhesion Protein-1 Blockade Suppresses Choroidal Neovascul arization (2008)
  • Author(s): Noda K, She H, Nakazawa T, et.al.
  • Journal Title: FASEB J. 22 Pages: 2928-2935
  • Peer Reviewed
• [Journal Article] A Novel mechanism of HIV protease inhibitors for neuroprotection through inhibition of mitochondrial apoptosis (2008)
  • Author(s): Hisatomi T, Nakazawa T
  • Journal Title: J Clin Invest. 118 Pages: 2025-2038
  • Peer Reviewed
• [Journal Article] Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicitv for amacrine cells (2008)
  • Author(s): Nakazawa T, et.al.
  • Journal Title: J Neurosci Res. 87 Pages: 1412-1423
  • Peer Reviewed
• [Journal Article] Pitavastatin Prevents NMDA-Induced Retinal Ganglion Cell Death By Suppressing Leukocyte Recruitment. (2007)
  • Author(s): Nakazawa T, 他, 7名
  • Journal Title: J Neurochem. 100 Pages: 1018-1031
  • Peer Reviewed
• [Journal Article] Monocytes Chemoattractant Protein-1 mediates retinal detachment-induced photoreceptor loss. (2007)
  • Author(s): Nakazawa T, 他, 12名
  • Journal Title: Proc Natl Acad Sci U S A. 104 Pages: 2425-2430
  • Peer Reviewed
• [Journal Article] Inhibition of nitric oxide synthetase reduces photoreceptor degeneration caused by photodynamic therapy in a model of choroidal neovascularization. (2007)
  • Author(s): She H, Nakazawa T, 他, 5名
  • Journal Title: Invest Ophthalmol Vis Sci. 48 Pages: 2268-2277
  • Peer Reviewed
• [Journal Article] Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin. (2007)
  • Author(s): Nakazawa T, 他, 9名
  • Journal Title: Invest Ophthalmol Vis Sci. 48 Pages: 2760-2768
  • Peer Reviewed
• [Journal Article] Pitavastatin Prevents NMDA-Induced Retinal Ganglion Cell Death By Suppressing Leukocyte Recruitment. (2007)
  • Author(s): Nakazawa Toru
  • Journal Title: Journal of Neurochemistry 100 Pages: 1018-1031
  • Peer Reviewed
• [Journal Article] Monocytes Chemoattractant Protein-1 mediates retinal detach ment-induced photoreceptor loss. (2007)
  • Author(s): Nakazawa Toru
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 2425-2430
  • Peer Reviewed
• [Journal Article] Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin. (2007)
  • Author(s): Nakazawa Toru
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 2760-2768
  • Peer Reviewed
• [Presentation] ミクログリア機能と緑内障-病因と治療- (2009)
  • Author(s): 中澤 徹
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-03-18
• [Presentation] 正常眼圧緑内障の視神経乳頭形状とMD slopeの相関 (2008)
  • Author(s): 中澤 徹
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-10-24
• [Presentation] 緑内障治療の基礎と臨床 (2008)
  • Author(s): 中澤 徹
  • Organizer: 第112回日本緑内障学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2008-09-13
• [Presentation] TNFα mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma (2008)
  • Author(s): 中澤 徹
  • Organizer: Neuroscience 2008
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 角膜輪部腫瘍性病変の外科的治療 (2008)
  • Author(s): 中澤 徹
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-04-20
• [Presentation] 網膜障害モデルにおけるミューラー細胞を介した神経保護作用 (2008)
  • Author(s): 中澤 徹
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-04-19
• [Presentation] マウス高眼圧モデルにおけるTNFaを介したオリゴデンドロサイト細胞死と網膜神経節細胞死 (2008)
  • Author(s): 中澤 徹
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-04-09
• [Presentation] マウス高眼圧モデルにおけるTNFaを介したオリゴデンドロサイト細胞死と網膜神経節細胞死 (2007)
  • Author(s): 中澤 徹
  • Organizer: 日本眼科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-04-20