Roles of rennin-angiotensin system in corneal neovascularization

• Project/Area Number: 19791258
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: The University of Tokyo
• Principal Investigator: USUI Tomohiko The University of Tokyo, 医学部附属病院, 助教 (80282557)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 角膜 / 血管新生 / アンジオテンシン / 炎症 / アンギオテンシン

Research Abstract

本研究では角膜血管新生におけるレニンアンジオテンシン系の分子の発現をmRNAレベル、蛋白レベル、組織レベルで検討し、その関与を明らかにした。次にアンジオテンシンI型受容体のアンタゴニスト(ARB)をマウス角膜血管新生モデルに投与することにより、角膜血管新生、角膜炎症が抑制され、様々な血管新生促進因子や炎症性サイトカインの発現が減弱した。以上からARBは角膜血管新生という角膜の透明性を脅かす重篤な病態の新たな治療法になると考えられた。

Research Products

• [Journal Article] Inflammatory corneal neovascularization and tissue rennin-angiotensin system (2009)
  • Author(s): Usui T, Ishida S, Amano S
  • Journal Title: Cornea (In press)
• [Journal Article] Inhibition of corneal neovasuclarization by blocking the angiotensin II type I receptor (2008)
  • Author(s): Usui T, Sugisaki K, Iriyama A, Yokoo S, Yamagami S, Nagai N, Ishida S, Amano S
  • Journal Title: Invest Ophthalmol Vis Sci 49 Pages: 4370-4378
• [Journal Article] Inhibition of corneal neovasuclarization by blocking angiotensin II type I receptor (2008)
  • Author(s): Usui T et.al
  • Journal Title: Invest Ophthalmol Vis Sci 49 Pages: 4370-4376
  • Peer Reviewed
• [Presentation] Inflamamtory corneal neovascularization and tissue rennin-angiotensin system (2008)
  • Author(s): Usui T
  • Organizer: Kyoto Cornea Club
  • Place of Presentation: Kyoto
  • Year and Date: 2008-12-06
• [Presentation] Inflammatory corneal neovascularization and tissue RAS (2008)
  • Author(s): Tomohiko Usui
  • Organizer: 京都コルネアクラブ
  • Place of Presentation: 京都
  • Year and Date: 2008-12-06
• [Presentation] Inflamamtory corneal neovascularization and tissue rennin-angiotensin system (2008)
  • Author(s): Usui T
  • Organizer: Japan Korea Corneal Joint Meeting
  • Place of Presentation: Seoul
  • Year and Date: 2008-10-03