Use of Magnetite Cationic Liposome for Gene Transfection to Ocular Cells and in vivo Promoter Analysis

• Project/Area Number: 19791262
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Nagoya University
• Principal Investigator: KACHI Shu Nagoya University, 医学部附属病院, 助教 (30345904)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,200,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 磁性微粒子 / Non viral / 遺伝子導入 / Magnetolipofection / 網膜色素上皮 / プロモーター / 遺伝子治療 / リポソーム / Magnetofection

Research Abstract

マグネトリポフェクションによりin vitroで培養網膜色素上皮(RPE)シートの任意の場所への選択的遺伝子導入が可能であり、導入効率はlipofectamin2000を使用した場合と同等であった。
また、lipofectamin2000の場合と異なり、この手法は細胞増殖に悪影響を与えなかった。さらに本法により重力方向ばかりでなく、横方向への選択的遺伝子導入も可能であり、in vivoにおいてもRPEへの遺伝子導入が可能であった。

Research Products

• [Journal Article] Concentration of Vascular Endothelial Growth Factor in Aqueous Humor of Eyes with Advanced Retinopathy of Prematurity before and after Intravitreal Injection of Bevacizumab (2009)
  • Author(s): Ito Nonobe N, Kachi S, Kondo M, Takai Y, Takemoto K, Nakayama A, Hayakawa M, Terasaki H
  • Journal Title: Retina
  • Peer Reviewed
• [Journal Article] Triamcinolone-assisted removal of internal limiting membrane enhances the effect of vitrectomy for diabetic macular edema (2009)
  • Author(s): Yamakoshi T, Kachi S, Sugita J, Asami T, Ishikawa K, Ito Y, Terasaki H
  • Journal Title: Ophthalmic Res
  • Peer Reviewed
• [Journal Article] A case of acute retinal necrosis after corticosteroid pulse therapy for unilateral Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Yokoi R, Asami T, Kachi S, Ito Y, Nakamura M, Terasaki H
  • Journal Title: Retinal Cases & Brief Reports
  • Peer Reviewed
• [Journal Article] Campochiaro PA. EIAV vector-mediated co-delivery of Endostatin and Angiostatin driven by the RPE-specific VMD2 Promoter Inhibits Choroidal Neovascularization (2009)
  • Author(s): Kachi S, Binley K, Yokoi K, Umeda N, Akiyama H, Igball S, Kan O, Naylor S
  • Journal Title: Hum Gene Ther
  • Peer Reviewed
• [Journal Article] Terasaki H. Generation of immature retinal neurons from proliferating cells in the pars plana after retinal histogenesis in mice with retinal degeneration (2009)
  • Author(s): Nishiguchi KM, Kaneko H, Nakamura M, Kachi S
  • Journal Title: Mol Vis 15 Pages: 187-199
  • Peer Reviewed
• [Journal Article] BEST1 expression in the retinal pigment epithelium is modulated by OTX family members (2009)
  • Author(s): Esumi N, Kachi S, Hackler L Jr, Masuda T, Yang Z, Campochiaro PA, Zack DJ
  • Journal Title: Hum Mol Genet 18(1) Pages: 128-141
  • Peer Reviewed
• [Journal Article] Concentration of Vascular Endothelial Growth Factor in Aqueous Humor of Eyes with Advanced Retinopathy of Prematurity before and after Intravitreal Injection of Bevacizumab (2009)
  • Author(s): Ito Nonobe N, Kachi S, et.al.
  • Journal Title: Retia (In press)
  • Peer Reviewed
• [Journal Article] Triamcinolone-assisted removal of internal limiting membrane enhances the effect of vitrectomy for diabetic macular edema (2009)
  • Author(s): Yamakoshi T, Kacbi S, et.al.
  • Journal Title: Ophthalmic Res. (In press)
  • Peer Reviewed
• [Journal Article] A case of acute retinal necrosis after corticosteroid pulse thatapy for unilateral Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Yokoi R, Asami T, Kachi S, et.al.
  • Journal Title: Retinal Cases & Brief Reports (In press)
  • Peer Reviewed
• [Journal Article] EIAV vector-mediated co-delivery of Endostatin and Angiostatin driven by the RPE-specific VMD 2 Promoter Inhibits Choroidal Neovascularization (2009)
  • Author(s): Eachi S, et.al.
  • Journal Title: Hum Gene Ther. (In press)
  • Peer Reviewed
• [Journal Article] Generation of immature retinal neurons from proliferating cells in the pars plena after retinal histogenesis in take with retinal degeneration (2009)
  • Author(s): Nishiguchi KM, Kaneko H, Nakamura M, Kazin S, Terasaki H
  • Journal Title: Mel Vis. 15 Pages: 187-199
  • Peer Reviewed
• [Journal Article] BEST1 expression in the retinal pigment epithelium is modulated. by OTX family members (2009)
  • Author(s): Esumi N, Kachi S, et.al.
  • Journal Title: Hum- Mol Genet. 18 Pages: 128-141
  • Peer Reviewed
• [Journal Article] Characteristics of bone marrow-derived microglia in the normal and injured retina (2008)
  • Author(s): Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H
  • Journal Title: Invest Ophthalmol Vis Sci 49(9) Pages: 4162-4168
  • Peer Reviewed
• [Journal Article] Campochiaro PA. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema (2008)
  • Author(s): Doukas J, Mahesh S, Umeda N, Kachi S, Akiyama H, Yokoi K, Cao J, Chen Z, Dellamary L, Tam B, Racanelli-Layton A, Hood J, Martin M, Noronha G, Soll R
  • Journal Title: J Cell Physiol 216(1) Pages: 29-37
  • Peer Reviewed
• [Journal Article] Pathak VP, Renick J, Soll R, Umeda N, Yee S, Yokoi K, Zeng B, Zhu H, Noronha G. Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotria zin-7 yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration (2008)
  • Author(s): Palanki MS, Akiyama H, Campochiaro P, Cao J, Chow CP, Dellamary L, Doukas J, Fine R, Gritzen C, Hood JD, Hu S, Kachi S, Kang X, Klebansky B, Kousba A, Lohse D, Mak CC, Martin M, McPherson A
  • Journal Title: J Med Chem 51(6) Pages: 1546-1559
  • Peer Reviewed
• [Journal Article] Retardation of photoreceptor degeneration in the detached retina of rd1 mouse (2008)
  • Author(s): Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H
  • Journal Title: Invest Ophthalmol Vis Sci 49(2) Pages: 781-787
  • Peer Reviewed
• [Journal Article] Identification of photoreceptor precursors in the pars plana during ocular development and after retinal injury (2008)
  • Author(s): Nishiguchi KM, Kaneko H, Nakamura M, Kachi S, Terasaki H
  • Journal Title: Invest Ophthalmol Vis Sci 49(1) Pages: 422-428
  • Peer Reviewed
• [Journal Article] Characteristics of bone marrow-derived microglia in the normal and injured retina (2008)
  • Author(s): Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Tarasaki H
  • Journal Title: Invest Ophthalmol Vis Soi. 49 Pages: 4162-4168
  • Peer Reviewed
• [Journal Article] Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neeovascularization and retinal edema (2008)
  • Author(s): Doukas J, Mahesh S, Umeda N. Kachi S, et.al.
  • Journal Title: j Cell Physiol. 216 Pages: 29-37
  • Peer Reviewed
• [Journal Article] The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration. (2008)
  • Author(s): Nishiguchi KMと
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 4315-4320
  • Peer Reviewed
• [Journal Article] Identification of photoreceptor precursors in the pars plana during ocular development and after retinal injury. (2008)
  • Author(s): Nishiguchi KM
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 422-428
  • Peer Reviewed
• [Journal Article] Retardation of Photoreceptor Degeneration in the Detached Retina of rdl Mouse. (2008)
  • Author(s): Kaneko H
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 781-787
  • Peer Reviewed
• [Journal Article] Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system (2007)
  • Author(s): Yokoi K, Zhang HS, Kachi S*, Balaggan KS, Yu Q, Guschin D, Kunis M, Surosky R, Africa LM, Bainbridge JW, Spratt SK, Gregory PD, Ali RR, Campochiaro PA
  • Journal Title: Mol Ther 15(11) Pages: 1917-1923
  • Peer Reviewed
• [Journal Article] The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization (2007)
  • Author(s): Lima e Silva R, Shen J, Hackett SF, Kachi S, Akiyama H, Kiuchi K, Yokoi K, Hatara MC, Lauer T, Aslam S, Gong YY, Xiao WH, Khu NH, Thut C, Campochiaro PA
  • Journal Title: FASEB J 21(12) Pages: 3219-3230
  • Peer Reviewed
• [Journal Article] The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration (2007)
  • Author(s): Nishiguchi KM, Nakamura M, Kaneko H, Kachi S, Terasaki H
  • Journal Title: Invest Ophthalmol Vis Sci 48(9) Pages: 4315-4320
  • Peer Reviewed
• [Journal Article] Ocular gene transfer with self-complementary AAV vectors (2007)
  • Author(s): Yokoi K, Kachi S*, Zhang HS, Gregory PD, Spratt SK, Samulski RJ, Campochiaro PA
  • Journal Title: Invest Ophthalmol Vis Sci 48(7) Pages: 3324-3328
  • Peer Reviewed
• [Journal Article] Preservation of macular oscillatory potentials in eyes of patients with retinitis pigmentosa and normal visual acuity (2007)
  • Author(s): Ikenoya K, Kondo M, Piao CH, Kachi S, Miyake Y, Terasaki H
  • Journal Title: Invest Ophthalmol Vis Sci 48(7) Pages: 3312-3317
  • Peer Reviewed
• [Journal Article] The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization. (2007)
  • Author(s): Lima e Silva R
  • Journal Title: FASEB J. 21 Pages: 3219-3230
  • Peer Reviewed
• [Journal Article] Preservation of macular oscillatory potentials in eyes of patients with retinitis pigmentosa and normal visual acuity. (2007)
  • Author(s): Ikenoya K
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 3312-3317
  • Peer Reviewed
• [Journal Article] Ocular gene transfer with self-complementary AAV vectors. (2007)
  • Author(s): Yokoi K, Kachi S (共同筆頭著者)
  • Journal Title: Invest Ophthalmol Vis Sci. 48 Pages: 3324-3328
  • Peer Reviewed
• [Journal Article] Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system. (2007)
  • Author(s): Yokoi K, Zhang HS, Kachi S (共同筆頭著者)
  • Journal Title: Mol Ther. 15 Pages: 1917-1923
  • Peer Reviewed
• [Presentation] 網膜色素上皮におけるウイルス由来プロモーター活性の比較 (2008)
  • Author(s): 加地秀
  • Organizer: 第47回日本網膜硝子体学会・第25回日本眼循環学会 合同学会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-29
• [Presentation] 網膜色素上皮におけるウイルス由来プロモーター活性の比較 (2008)
  • Author(s): 加地秀
  • Organizer: 第47回日本綱膜硝子体学会・第25回日本眼循環学会合同学会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-29
• [Presentation] 網膜静脈分枝閉塞の黄斑浮腫に対するベバシズマブ注入療法に成績に関与する因子 (2008)
  • Author(s): 近藤峰生、伊藤逸毅、加地秀、安間哲宏、菊池雅人、寺崎浩子、近藤永子、太田一郎、三宅謙作
  • Organizer: 第47回日本網膜硝子体学会・第25回日本眼循環学会 合同学会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-28
• [Presentation] 網膜静脈分枝閉塞の黄斑浮腫に対するべバシズマブ注入療法に成績に関与する因子 (2008)
  • Author(s): 近藤峰生、伊藤逸毅、加地秀, 他
  • Organizer: 第47回日本網膜硝子体学会・第25回日本眼循環学会合個学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-28
• [Presentation] 網膜静脈分枝閉塞の黄斑浮腫に対するベバシブマブ注入12か月後の成績 (2008)
  • Author(s): 近藤峰生、伊藤逸毅、加地秀、近藤永子、太田一郎、三宅謙作、寺崎浩子
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-24
• [Presentation] 網膜静脈分枝閉塞の黄斑浮腫に対するベバブマブ注入12か月後の成績 (2008)
  • Author(s): 近藤峰生、伊藤逸毅、加地秀, 他
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-24
• [Presentation] Gene transfection to human retinal epitherial cells using magnetite cationic liposome (2008)
  • Author(s): Kachi S, Fujii Y, Kaneko H, Kawasumi T, Honda H, Terasaki H
  • Organizer: 第14回日本遺伝子治療学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-14
• [Presentation] Gene transfection to human retinal epitherial cells using magnetite-cationic liposome (2008)
  • Author(s): Kachi S, 他
  • Organizer: 第14回日本遺伝子治療学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-14
• [Presentation] Circulating Bone Marrow Derived Microglias Engraft Into the Injured Retina (2008)
  • Author(s): Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H
  • Organizer: ARVO Annual Meeting (The Association for Research in Vision and Ophthalmology)
  • Place of Presentation: USA
  • Year and Date: 2008-05-01
• [Presentation] Circulating Bone Marrow Derived Microglias Engraft Into the Injured Retina (2008)
  • Author(s): Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: アメリカ,フロリダ
  • Year and Date: 2008-05-01
• [Presentation] Prolonged Presence of Photoreceptor Precursors in the Ciliary Epithelium of Mice With Hereditary Retinal Degeneration (2008)
  • Author(s): Nishiguchi KM, Kaneko H, Nakamura M, Kachi S, Terasaki H
  • Organizer: ARVO Annual Meeting (The Association for Research in Vision and Ophthalmology)
  • Place of Presentation: USA
  • Year and Date: 2008-04-29
• [Presentation] ATN-224.021 and ATN-427.021 Suppress Choroidal Neovascularization (2008)
  • Author(s): Kachi S, Umeda N, Akiyama H, Kachi M, Hackett SF, Mazar AP
  • Organizer: ARVO Annual Meeting (The Association for Research in Vision and Ophthalmology)
  • Place of Presentation: USA
  • Year and Date: 2008-04-29
• [Presentation] ATN-224.021 and ATN-427.021 Suppress Choroidal Neovascularization (2008)
  • Author(s): Kachi S, et.al.
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: アメリカ,フロリダ
  • Year and Date: 2008-04-29
• [Presentation] Prolonged Presence of Photoreceptor Precursors in the Ciliary Epithelium of Mice With Hereditary Retinal Degeneration (2008)
  • Author(s): Nishiguchi KM, Kaneko H, Nakamura M, Kachi S, Terasaki H
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: アメリカ,フロリダ
  • Year and Date: 2008-04-29
• [Presentation] Increased Macular Volume at Onset Followed by Gradual Decrease in Eyes With Acute Zonal Occult Outer Retinopathy (2008)
  • Author(s): Ito Y, Kondo M, Kachi S, Nakamura M, Asano T, Terasaki H
  • Organizer: ARVO Annual Meeting (The Association for Research in Vision and Ophthalmology
  • Place of Presentation: USA
  • Year and Date: 2008-04-28
• [Presentation] Concentration of Vascular Endothelial Growth Factor in Aqueous Humor of Eyes With Advanced Retinopathy of Prematurity (2008)
  • Author(s): Ito N, Kachi S, Kondo M, Terasaki H
  • Organizer: ARVO Annual Meeting (The Association for Research in Vision and Ophthalmology
  • Place of Presentation: USA
  • Year and Date: 2008-04-28
• [Presentation] Concentration of Vascular Endothelial Growth Factor in Aqueous Humor of Eyes With Advanced Retinopathy of Prematurity (2008)
  • Author(s): Ito N, Kachi S, et.al.
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: アメリカフロリダ
  • Year and Date: 2008-04-28
• [Presentation] Increased Macular Volume at Onset Followed by Gradual Decrease in Eyes With Acute Zonal Occult Outer Retinopathy (2008)
  • Author(s): Ito Y, Rondo M, Kachi S, et.al.
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: アメリカ,フロリダ
  • Year and Date: 2008-04-28
• [Presentation] Gene Transfection to Human Retinal Pigment Epithelial Cells Using Magnetite Cationic Liposome (2008)
  • Author(s): Fujii Y, Kachi S, Kaneko H, Kawasumi T, Honda H, Terasaki H
  • Organizer: ARVO Annual Meeting (The Association for Research in Vision and Ophthalmology)
  • Place of Presentation: USA
  • Year and Date: 2008-04-27
• [Presentation] Gene Transfection to Human Retinal Pigment Epithelial Cells Using Magnetite Cationic Liposome (2008)
  • Author(s): Fujii Y, Kachi S, et.al.
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: アメリカ,フロリダ
  • Year and Date: 2008-04-27
• [Presentation] 血管阻害剤Combretastatin A4 phosphateの眼内血管新生退縮効果 (2008)
  • Author(s): 梅田尚靖、加地秀、秋山英夫
  • Organizer: 第112回日本眼科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18
• [Presentation] 重症未熟児網膜症の血管内皮増殖因子濃度 (2008)
  • Author(s): 伊藤典枝、加地秀、近藤峰生、高井佳子、寺崎浩子
  • Organizer: 第112回日本眼科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18
• [Presentation] 重症未熟児網膜症の眼内VEGFとbevacizumab (2008)
  • Author(s): 加地秀
  • Organizer: 第112回日本眼科学会 シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18
• [Presentation] 重症未熟児網膜症の眼内VEGFとbevacizumab (2008)
  • Author(s): 加地秀
  • Organizer: 第112回日本眼科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18
• [Presentation] 血管阻害剤Combretastatin A 4 phosphateの眼内血管新生退縮効果 (2008)
  • Author(s): 梅田尚靖、加地秀, 他
  • Organizer: 第112回日本眼科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18
• [Presentation] 増殖糖尿病網膜症に対するbevacizumab硝子体手術前投与の影響 (2008)
  • Author(s): 牛田宏昭、浅見哲、加地秀、石川浩平、近藤峰生、寺崎浩子
  • Organizer: 第13回日本糖尿病眼学会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-16
• [Presentation] 増殖糖尿病網膜症に対するbevacizumab硝子体手術前投与の影響 (2008)
  • Author(s): 牛田宏昭
  • Organizer: 第14回日本糖尿病眼学会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-16
• [Presentation] 未熟児網膜症 stage4 に対するバックリング手術 (2008)
  • Author(s): 伊藤典枝、高井佳子、近藤峰生、加地秀、寺崎浩子
  • Organizer: 第31回日本眼科手術学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-02-01
• [Presentation] 未熟児網膜症stage4に対するバックリング手術 (2008)
  • Author(s): 伊藤典枝
  • Organizer: 第31回日本眼科手術学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-02-01
• [Presentation] Surgical Treatment and Vascular Endothelial Growth Factor in Eyes with Advanced Retinopathy of Prematurity (2008)
  • Author(s): Terasaki H, Ito N, Kachi S, Takai Y, Kondo M
  • Organizer: XXVIth Meeting of the Club Jules Gonin
  • Place of Presentation: Switzerland
• [Presentation] Concentration of vascular endothelial growth factor in aqueous humour of eyes with advanced retinopathy of prematurity (2008)
  • Author(s): Ito N, Kachi S, Kondo M, Takai Y, Terasaki H
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: Hong Kong
• [Presentation] Triamcinolone-assisted removal of intermal limiting membrane enhances the effect of vitrectomy for diabetic macular edema (2008)
  • Author(s): Kachi S, Yamakoshi T, Sugita J, Asami T, Ishikawa K, Ito Y, Terasaki H
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: Hong Kong
• [Presentation] Triamcinolone-assisted removal of intermal limiting membrane enhances the effect of vitrectomy for diabetic macular edema (2008)
  • Author(s): Kachi S, et.al.
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: 中国, 香港
• [Presentation] Concentration of vascular endothelial growth factor in aqueous humour of eyes with advanced retinopathy of prematuity (2008)
  • Author(s): Ito N, Kachi S, et.al.
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: 中国, 香港
• [Presentation] Surgical Treatment and Vascular Endothelial Growth Factor in Eyes with Advanced Retinopathy of Prematurity (2008)
  • Author(s): Terasaki H, Ito N, Kachi S, et.al.
  • Organizer: XXVIth Meeting of the Club Jules Gonin
  • Place of Presentation: スイス・サンモリンツ
• [Presentation] 片眼性AZOORの発症初期黄斑部網膜厚変化 (2007)
  • Author(s): 伊藤逸毅、近藤峰生、加地秀、中村誠、寺崎浩子
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-25
• [Presentation] PDGF-Bアプタマーの硝子体注射は増殖網膜症を抑圧する (2007)
  • Author(s): 秋山英雄
  • Organizer: 46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-25
• [Presentation] 骨髄由来細胞のマウス網膜内への生着 (2007)
  • Author(s): 兼子裕規、西口康二、中村誠、加地秀、寺崎浩子
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] 磁性微粒子を用いた網膜色素上皮細胞への遺伝子導入 (2007)
  • Author(s): 藤井康生、加地秀、兼子裕規、寺崎浩子
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] テトラチオモリブテン酸とテトラチオタングステン酸の脈絡膜新生血管に対する効果 (2007)
  • Author(s): 加地秀、梅田尚靖、秋山英雄
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] PDGF-Bアプタマーの硝子体注射は増殖網膜症を抑圧する (2007)
  • Author(s): 秋山英雄、加地秀、梅田尚靖
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] 骨髄由来細胞のマウス網膜内への生着 (2007)
  • Author(s): 兼子裕規
  • Organizer: 46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] 磁性微粒子を用いた網膜色素上皮細胞への遺伝子導入 (2007)
  • Author(s): 藤井康生
  • Organizer: 46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] テトラチオモリブテン酸とテトラチオタングステン酸の脈絡膜新生血管に対する効果 (2007)
  • Author(s): 加地秀
  • Organizer: 46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-24
• [Presentation] 網膜中心静脈分枝閉塞に対するベバシズマブ注入6カ月後の成績 (2007)
  • Author(s): 近藤峰生、伊藤逸毅、加地秀、石川浩平、寺崎浩子、近藤永子、太田一郎、三宅謙作
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-23
• [Presentation] 未熟児網膜症に対するbevacizumab硝子体注射 (2007)
  • Author(s): 伊藤典枝、近藤峰生、加地秀、高井佳子、寺崎浩子
  • Organizer: 第46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-23
• [Presentation] 網膜中心静脈分枝閉塞に対するベバシズマブ注入6カ月後の成績 (2007)
  • Author(s): 近藤峰生
  • Organizer: 46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-23
• [Presentation] 未熟児網膜症に対するbevacizumab硝子体注射 (2007)
  • Author(s): 伊藤典枝
  • Organizer: 46回日本網膜硝子体学会
  • Place of Presentation: 青森
  • Year and Date: 2007-11-23
• [Presentation] 抗VEGF抗体 網膜中心静脈分岐閉塞に伴う黄斑浮腫に対するベバシズマブ注入後の黄斑部局所網膜電図 (2007)
  • Author(s): 栗本幸英、近藤峰生、加地秀、朴昌華、杉田糾、中村美晴、伊藤逸毅、寺崎浩子
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-12
• [Presentation] Inhibition of Choroidal Neovasucularization by Angioinhibitory Genes Derived by the RPE Specific Promoter (2007)
  • Author(s): Kachi S, Binley K, Umeda N, Akiyama H, Yokoi K, Xiao W, Kachi M, Esapa M, Iqball S, Kan O, Picard M, Naylor S, Campochiaro PA
  • Organizer: 第13回日本遺伝子治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-30
• [Presentation] Inhibition of Choroidal Neovasucularization by Angioinhibitory Genes Derived by the RPE Specific Promoter. (2007)
  • Author(s): 加地 秀
  • Organizer: 第13回日本遺伝子治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-30