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Differential induction and application to regenerative medicine of ocular tissue-specific stem cells

Research Project

Project/Area Number 19791266
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

INOUE Tomoyuki  Osaka University, 医学系研究科, 助教 (50432539)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords再生医療 / 眼組織 / 網膜 / 角膜
Research Abstract

For clinical application of regenerative medicine against severe ocular diseases, we investigated the ocular tissue-specific stem cells as a cell source for the target cells. We shown that modulation of retinal transcription factor gene expression in human RSCs greatly enriches for photoreceptor progeny, and that strong enrichment was obtained with the combined transduction of OTX2 and CRX together with the modulation of CHX10. These results were published on Stem Cells 2010 ; 28 : 489-500. In corneal regeneration therapy, we investigated the feeder cells for the cultivated cell sheet transplantation.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Maximizing functional photoreceptor differentiation from adult human retinal stem cells.2010

    • Author(s)
      Inoue T, Coles BLK, Dorval K, Bremner R, Bessho Y, Kageyama R, Hino S, Matsuoka M, Craft CM, Mclnnes RR, Temblay F, Prusky GT, van der Kooy D
    • Journal Title

      Stem Cells 28

      Pages: 489-500

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maximizing functional photoreceptor differentiation from adult human retinal stem cells2009

    • Author(s)
      井上智之
    • Journal Title

      Stem Cells 28(3)

      Pages: 489-500

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 網膜幹細胞から網膜視細胞・網膜神経節細胞・網膜色素上皮細胞への分化誘導2008

    • Author(s)
      高松文彦、井上智之、田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 網膜幹細胞から網膜視細胞・網膜神経節細胞・網膜色素上皮細胞への分化誘導2008

    • Author(s)
      高松文彦、井上智之、田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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