Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy.

• Project/Area Number: 19791278
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Sapporo Medical University
• Principal Investigator: NISHIKIORI Nami Sapporo Medical University, 医学部, 研究員 (30444920)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,840,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥540,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 網膜血管病変 / レチノイン酸 / グリア細胞 / 糖尿病網膜症 / 加齢性黄斑変性症 / 網膜血管関門 / サイトカイン / VEGF / GDNF

Research Abstract

糖尿病の三大合併症の一つである糖尿病網膜症は失明原因の第一位である。我々はこの糖尿病網膜症に対する新しい予防法および治療法を開発することを本研究の最終目的としている。
我々はレチノイン酸を用いることで、糖尿病網膜症に関わるサイトカインを制御し、眼内微小環境を血管透過性抑制系の優位へと導くことで、結果的に糖尿病網膜症における網膜血管病変を制御することに成功した。
糖尿病網膜症に対し、新しい予防法および治療法を開発する基盤を確立できたと思われる。

Research Products

• [Journal Article] Prevention of Murine Experimental Corneal Trauma by Epigenetic Events Regulating Claudin 6 and Claudin 9. (2008)
  • Author(s): Nishikiori N, Sawada N, Ohguro H.
  • Journal Title: Jpn J Ophthalmol. 52 Pages: 195-203
  • NAID: 10024154041
  • Peer Reviewed
• [Journal Article] An intractable case of Pseudomonas aeruginosa infection after scleral buckling for rhegmatogenous retinal detachment. (2008)
  • Author(s): Nishikiori N, Ohguro H.
  • Journal Title: Clinical Ophthalmology. 2 Pages: 223-225
  • Peer Reviewed
• [Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy. (2008)
  • Author(s): Nishikiori N, Osanai M, Chiba H, Kojima K, Inatomi S, Ohguro H, Sawada N.
  • Journal Title: Clinical Ophthalmology. 2 Pages: 233-235
  • Peer Reviewed
• [Journal Article] Prevention of Murine Experimental Corneal Trauma by Epigenetic Events Regulating Claudin 6 and Claudin 9 (2008)
  • Author(s): 錦織奈美
  • Journal Title: Jpn J Ophthalmol 52 Pages: 195-203
  • NAID: 10024154041
  • Peer Reviewed
• [Journal Article] An intractable case of Pseudomonas aeruginosa infection after scleral buckling for rhegmatogenous retinal detachment (2008)
  • Author(s): 錦織奈美
  • Journal Title: Clinical Ophthalmology 2 Pages: 223-225
  • Peer Reviewed
• [Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy (2008)
  • Author(s): 錦織奈美
  • Journal Title: Clinical Ophthalmology 2 Pages: 233-235
  • Peer Reviewed
• [Journal Article] Prevention of Murine Experimental Corneal Trauma by Epigenetic Events Regulating Claudin 6 and Claudin 9 (2008)
  • Author(s): 錦織 奈美
  • Journal Title: JJO (in press)
  • NAID: 10024154041
  • Peer Reviewed
• [Journal Article] An intractable case of Pseuclomonas aeruginosa infection after scleral buckling for rhegmatogenous retinal detachment (2008)
  • Author(s): 錦織 奈美
  • Journal Title: Clinical Ophthalmology 2 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy (2008)
  • Author(s): 錦織 奈美
  • Journal Title: Clinical Ophthalmology 2 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Glial Cell-Derived Cytokines Attenuate the breakdown of Vascular Integrity in Diabetic Retinopathy. (2007)
  • Author(s): Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, Sawada N.
  • Journal Title: Diabetes. 56 Pages: 1333-1340
  • Peer Reviewed
• [Journal Article] Retinoic Acid Receptor Alpha Stimulants Prevent Murine Cataractogenesis through Suppression of Deregulated Calpains. (2007)
  • Author(s): Nishikiori N, Osanai M, Chiba H, Kojima T, Ohguro H, Sawada N.
  • Journal Title: Invest Ophthalmol Vis Sci. 48 Pages: 2224-2229
  • Peer Reviewed
• [Journal Article] Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells. (2007)
  • Author(s): Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N.
  • Journal Title: Cancer Sci. 98 Pages: 1027-1034
  • NAID: 120002187916
  • Peer Reviewed
• [Journal Article] Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor Alpha Agonists in Colitis. (2007)
  • Author(s): Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N.
  • Journal Title: Mol Pharmacol. 71 Pages: 250-258
  • Peer Reviewed
• [Journal Article] Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy (2007)
  • Author(s): 錦織 奈美
  • Journal Title: Diabetes 56 Pages: 1333-1340
  • Peer Reviewed
• [Journal Article] Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains (2007)
  • Author(s): 錦織 奈美
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 2224-2229
  • Peer Reviewed
• [Journal Article] Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells (2007)
  • Author(s): 小山内 誠
  • Journal Title: Cancer Sci 98 Pages: 1027-1034
  • Peer Reviewed
• [Journal Article] Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis (2007)
  • Author(s): 小山内 誠
  • Journal Title: Mol Pharmacol 71 Pages: 250-258
  • Peer Reviewed
• [Presentation] レチノイドによる新たな糖尿病網膜症の予防および治療法の検討 (2008)
  • Author(s): 錦織 奈美
  • Organizer: 糖尿病眼学会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-14
• [Presentation] レチノイドによる新たな糖尿病網膜症の予防および治療法の検討. (2008)
  • Author(s): 錦織奈美,菅原敦史,大黒浩.
  • Organizer: 糖尿病眼学会.
  • Place of Presentation: 東京
  • Year and Date: 2008-03-03
• [Presentation] 輪状締結術後早期に発症した緑膿菌による難治性のBuckle感染症の一例. (2007)
  • Author(s): 錦織奈美,大黒浩.
  • Organizer: 北海道眼科集談会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-06
• [Presentation] 輪状締結術後早期に発症した緑膿菌による難治性のBuckle感染症の一例 (2007)
  • Author(s): 錦織 奈美
  • Organizer: 眼科地方会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-06
• [Presentation] 網膜グリア細胞を標的とした新たな糖尿病網膜症の予防および治療法の検討 (2007)
  • Author(s): 錦織 奈美
  • Organizer: 日本眼科学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-20
• [Presentation] 輪状締結術後早期に発症した緑膿菌による難治性のBuckle感染症の一例 (2007)
  • Author(s): 錦織奈美,大黒浩
  • Organizer: 北日本眼科学会
  • Place of Presentation: 新潟
• [Presentation] 網膜グリア細胞を標的とした新たな糖尿病網膜症の予防および治療法の検討 (2007)
  • Author(s): 錦織奈美,澤田典均,大黒浩
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 大阪
• [Presentation] Glial cell line-derived neurotrophic factor regulates the vascular permeability of the blood-retinal battier. (2007)
  • Author(s): Nishikiori N, Osanai M, Kawata H, Chiba H, Kojima T, Sawada N, Ohguro H.
  • Organizer: Asia ARVO.
  • Place of Presentation: Singapore
• [Book] Neuro-ophthalmol Jpn (2007)
  • Author(s): Nishikiori N, Kawata H, Hashimoto M, Ohguro H.
  • Publisher: Physiological and Clinical Aspect of the Neuroretinal Circuit (5): Homeostatic regulation of the blood-retinal barrier by cytokines and its implication for a new diabetic retinopathy therapy.
• [Book] 臨床眼科増刊号 (2007)
  • Author(s): 錦織奈美,大黒浩
  • Publisher: 悪性腫瘍随伴網膜症
• [Book] 臨床眼科 (2007)
  • Author(s): 錦織 奈美
  • Total Pages: 3
  • Publisher: 悪性腫瘍随伴網膜症
• [Book] Physiological and Clinical Aspect of the Neuroretinal Circuit (5) (2007)
  • Author(s): 錦織 奈美
  • Total Pages: 8
  • Publisher: Homeostatic regulation of the blood-retinal barrier by cytokin es and its implication for a new diabetic retinopathy therapy
• [Patent(Industrial Property Rights)] PCT出願 (2006)
  • Inventor(s): 澤田典均,小山内誠,錦織奈美
  • Industrial Property Rights Holder: 澤田典均,小山内誠,錦織奈美
  • Filing Date: 2006-09-25
  • Overseas