Investigation into the role of TNF-alpha in diabetic retinopathy

• Project/Area Number: 19791279
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Nagoya City University
• Principal Investigator: MATSUBARA Akihisa Nagoya City University, 大学院・医学研究科, 助教 (80336685)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,830,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 眼科学 / 糖尿病ラット / アクリジンオレンジ / 白血球 / TNF-alpha

Research Abstract

TNF-alpha産生阻害薬は糖尿病ラット網膜の白血球集積を抑制した。TNF-alpha産生阻害薬は糖尿病網膜症における白血球-血管内皮間の粘着能亢進を改善することが示唆された。

Research Products

• [Journal Article] Pitavastatin attenuatesleukocyte-endothelial in teractions induced by ischemia-reperfusion injury in the rat retina. (2009)
  • Author(s): Miyaki K, Matsubara A, Nishiwaki A, Tomida K, Morita H, Yoshida M, Ogura Y.
  • Journal Title: Curr Eye Res. 34(1) Pages: 10-17
  • Peer Reviewed
• [Journal Article] Pitavastatin attenuates leukocyte-endothelial interactions induced by ischemia-renerfusion iniury in the rat retina (2009)
  • Author(s): Miyaki Kenichi
  • Journal Title: Curr Eye Res 34 Pages: 10-17
  • Peer Reviewed
• [Journal Article] Effect of posterior sub-tenon administration of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation after panretinal photocoagulation. (2008)
  • Author(s): Mizuno D, Matsubara A, Ogura Y.
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 2127-2133
  • Peer Reviewed
• [Journal Article] Photodynamic therapy induces caspase-dependent apoptosis in rat CNV model (2007)
  • Author(s): 松原 明久
  • Journal Title: Investigative Ophthalmology & Visual Science 48 Pages: 4741-4747
  • Peer Reviewed
• [Presentation] Aldose reductase inhibitor attenuates leukocyte-endothelial interaction in experimental diabetic retina in vivo. (2008)
  • Author(s): Hattori T, Matsubara A, Taniguchi K, Ogura Y
  • Organizer: Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: フォートローダーデール、米国
• [Presentation] 糖尿病ラットにおける網膜白血球集積に対するアルドース還元酵素阻害薬の抑制効果 (2008)
  • Author(s): 服部知明、松原明久、谷口香織、小椋祐一郎
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 横浜
• [Presentation] 糖尿病ラットにおける網膜白血球集積に対する腫瘍壊死因子(TNF・alpha)阻害薬の抑制効果 (2007)
  • Author(s): 服部 知明
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-04-19
• [Presentation] 糖尿病ラットにおける網膜白血球集積に対する腫瘍壊死因子(TNF-α)阻害薬の抑制効果 (2007)
  • Author(s): 服部知明、松原明久、小椋祐一郎
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪