ADAM28 plays an important role in ocular neovascularization

• Project/Area Number: 19791290
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: SHINODA Hajime Keio University, 医学部, 助教 (30306766)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 血管新生 / 網膜 / 炎症

Research Abstract

眼内血管新生は、失明に直結する網膜疾患である糖尿病網膜症・加齢黄班変性における共通の進行期病態である。これらの疾患では炎症に続発して病理的な血管新生が発症するため、これらの網膜疾患を治療するには炎症性血管新生を制御することが鍵となると考えられる。我々は糖尿病網膜症(PDR)においてADAM28が線維血管組織に局在し、また非血管性増殖組織である網膜上膜と比し線維血管組織において有意な発現増加を来していることを明らかにした。PDRの病態促進にADAM28が関与している可能性が示唆された。

Research Products

• [Journal Article] Jamming of 25-gauge instruments in the cannula during vitrectomy for vitreous haemorrhage (2008)
  • Author(s): Shinoda H, Nakajima T, Shinoda K, Suzuki K, Ishida S, Inoue M
  • Journal Title: Acta Ophthalmol 86(2) Pages: 160-164
• [Journal Article] Visual recovery after vitrectomy for macular hole using 25-gauge instruments (2008)
  • Author(s): Shinoda H, Shinoda K, Satofuka S, Imamura Y, Ozawa Y, Ishida S, Inoue M
  • Journal Title: Acta Ophthalmol 86(2) Pages: 151-155
• [Journal Article] Two-step oblique incision during 25-gauge vitrectomy reduces incidence of postoperativehypotony (2007)
  • Author(s): Inoue M, Shinoda K, Shinoda H, Kawamura R, Suzuki K, Ishida S
  • Journal Title: Clin Experiment Ophthalmol 35(8) Pages: 693-696
• [Journal Article] Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2 (2007)
  • Author(s): Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T,Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 48(10) Pages: 4795-4801
• [Journal Article] Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice (2007)
  • Author(s): Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 48(9) Pages: 4328-4334
• [Journal Article] 25-gauge cannula system with microvitreoretinal blade trocar (2007)
  • Author(s): Inoue M, Shinoda K, Shinoda H, Suzuki K, Kawamura R, Ishida S
  • Journal Title: Am J Ophthalmol 144(2) Pages: 302-304
• [Journal Article] Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia (2007)
  • Author(s): Sugisaka E, Shinoda K, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M
  • Journal Title: Am J Ophthalmol 144(2) Pages: 245-251
• [Journal Article] Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme : minimal role of bradykinin (2007)
  • Author(s): Nagai N, Oike Y, Izumi-Nagai K, Koto T, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 48(5) Pages: 2321-2326
• [Journal Article] Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells (2007)
  • Author(s): Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
  • Journal Title: Am J Pathol 170(4) Pages: 1389-1397
• [Journal Article] Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization (2007)
  • Author(s): Satofuka S, Ichihara A, Nagai N, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota T, Itoh H, Oike Y, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 422-429
• [Presentation] 転移性脈絡膜腫瘍に対してBevacizumab硝子体内投与を施行した1例 (2008)
  • Author(s): 稲垣絵海,篠田肇,川村亮介,内田敦郎,鈴木浩太郎,野田航介,小沢洋子,石田晋,坪田一男
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] 経角膜電気刺激にて視力改善を認めたBEST病の1症例 (2008)
  • Author(s): 尾関直毅,篠田肇,野田航介,小沢洋子,篠田啓,坪田一男,石田晋
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] Macular microholeに対してトリアムシノロンテノン嚢下注入を行なった一例 (2008)
  • Author(s): 森山あづさ,野田航介,内田敦郎,川村亮介,篠田肇,小沢洋子,坪田一男,石田晋
  • Organizer: 第47回網膜硝子体学会
  • Place of Presentation: 京都
• [Presentation] 硝子体手術後に生じた黄斑円孔に対してトリアムシノロン投与を行なった網膜中心静脈閉塞症の一例 (2008)
  • Author(s): 山中美穂,野田航介,内田敦郎,川村亮介,篠田肇,小沢洋子,坪田一男,石田晋
  • Organizer: 第47回網膜硝子体学会
  • Place of Presentation: 京都
• [Presentation] Anti-inflammatory effect of eicosapentaenoic acid on diabetic retina in vivo and cytokine expression in vitro (2007)
  • Author(s): Koto T, Nagai N, Mochimaru H, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Kurihara T, Ozawa Y, Inoue M, Tsubota K, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A
• [Presentation] Nonproteolytically activated prorenin promotes pathologic, but not physiologic, retinal neovascularization (2007)
  • Author(s): Satofuka S. Ichihara A, Nagai N, Koto T, Shinoda H, Ozawa Y, Tsubota K, Itoh H, Oike Y, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A