Suppression of Choroidal Neovascularization with omega-3 polyunsaturated fatty acid

• Project/Area Number: 19791291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: MOCHIMARU Hiroshi Keio University, 医学部, 研究員(非常勤) (90424168)
• Research Collaborator: KOTO Takashi 慶應義塾大学, 医学部, 助教 (60464814)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 脈絡膜血管新生 / EPA / オメガ3多価不飽和脂肪酸 / 接着分子 / 加齢黄斑変性 / 炎症

Research Abstract

オメガ-3多価不飽和脂肪酸の一つであるエイコサペンタエン酸(EPA)摂取は脈絡膜における炎症抑制を介して加齢黄斑変性(AMD)の本態である脈絡膜血管新生(CNV)を抑制することが示された。またCNVの抑制は眼局所のみならず全身の炎症レベルの低下による可能性が示唆された。現在米国ではEPAのAMD発症に対する介入試験が行われている。本研究はその生物学的根拠となりうるものである。

Research Products

• [Journal Article] Resveratrol Prevents Ocular Inflammation in Endotoxin-Induced Uveitis via Inhibiting Oxidative Damage and Nuclear Factor-{kappa}B Activation (2009)
  • Author(s): Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K
  • Journal Title: Invest Ophthalmol Vis Sci
• [Journal Article] サプリメントサイエンスセミナー オメガ-3多価不飽和脂肪酸 (2008)
  • Author(s): 厚東隆志et al
  • Journal Title: あたらしい眼科 25 Pages: 1527-1529
• [Journal Article] Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2 (2008)
  • Author(s): Mochimaru H, Usui T, Yaguchi T, Nagahama Y, Hasegawa G, Usui Y, Shimmura S, Tsubota K, Amano S, Kawakami Y, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 49(5) Pages: 2172-2177
• [Journal Article] サプリメントサイエンスセミナーオメガ-3多価不飽和脂肪酸 (2008)
  • Author(s): 厚東隆志、野田航介
  • Journal Title: あたらしい眼科 25 Pages: 1527-1529
  • Peer Reviewed
• [Journal Article] Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2 (2007)
  • Author(s): Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T,Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 48(10) Pages: 4795-4801
• [Journal Article] Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice (2007)
  • Author(s): Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S
  • Journal Title: InvestOphthalmol Vis Sci 48(9) Pages: 4328-4334
• [Journal Article] Eicosapentaenoic Acid is anti-inflammatory in preventing choroidalneovascularization in mice (2007)
  • Author(s): Koto T, Mochimaru H., et. al.
  • Journal Title: Investigative Ophthalmology & Visual Sciences 48(9) Pages: 4328-4334
  • Peer Reviewed
• [Presentation] Involvement of Hyarulonan With Choroidal Neovascularization (2008)
  • Author(s): Mochimaru H, Takahashi E, Tsubota K, Saya H, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)
  • Place of Presentation: Florida, USA
  • Year and Date: 2008-04-27
• [Presentation] Suppression of Alkali Burn-Induced Corneal Neovascularization by Dendric Cell Vaccination Targeting VEGF Receptor2 (2008)
  • Author(s): Usui T, Mochimaru H, Usui S, Yamaguchi S, Amano S, Tsubota K, Kawakami Y, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)
  • Place of Presentation: Florida, USA
  • Year and Date: 2008-04-27
• [Presentation] エイコサペンタエン酸の摂取による実験的脈絡膜血管新生の抑制効果 (2007)
  • Author(s): 厚東隆志,持丸博史et al
  • Organizer: 第41回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
• [Presentation] Lutein Inhibits Choroidal Neovascularization in Mice (2007)
  • Author(s): Izumi-Nagai K, Nagai N, Satofuka S, Koto T, Mochimaru H, Tsubota K, Ohgami K, Ohno S, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A
• [Presentation] Anti-inflammatory effect of eicosapentaenoic acid on diabetic retina in vivo and cytokine expression in vitro (2007)
  • Author(s): Koto T, Nagai N, Mochimaru H, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Kurihara T, Ozawa Y, Inoue M, Tsubota K, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A
• [Presentation] Immunization of mice with dendritic cells primed with epitope peptide derived from VEGF receptor 2 supresses choroidal neovascularization (2007)
  • Author(s): Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Satofuka S, Ozawa Y, Tsubota K, Kawakami Y, Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A