Depressor effect of pigment epithelium-derived factor (PEDF) on vascular permeability.

• Project/Area Number: 19791303
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kurume University
• Principal Investigator: MATSUI Takanori Kurume University, 医学部, 研究員 (10425233)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 糖尿病性網膜症 / 糖尿病 / シグナル伝達 / 分子生物学

Research Abstract

糖尿病腎症の進展阻止が期待される蛋白質として色素上皮由来因子(Pigmentepithelium-derived factor:以下PEDF)に着目した。PEDFの抗酸化ストレス活性が腎症の初期病変を改善するのか検討するために、テトラサイクリン投与によりヒトPEDFの発現が誘導されるマウスを作製して、ストレプトゾトシン投与による糖尿病モデルを用いて糖尿病網膜症の抑制効果を確認することが可能になった。

Research Products

• [Journal Article] Administration of pigment epithelium-derived factor prolongs bleeding time by suppressing plasminogen activator inhibitor-1 activity and platelet aggregation in rats (2009)
  • Author(s): Yamagishi S, Matsui T, Nakamura K, Takenaka K.
  • Journal Title: Clinical and Experimental Medicine 9 Pages: 731-736
  • Peer Reviewed
• [Journal Article] Pigment epithelium-derived factor inhibits vascular endothelial growth factor-induced vascular hyperpermeability both in vitro and in vivo. (2007)
  • Author(s): Yamagishi Sho-ichi
  • Journal Title: Journal of International Medical Research. 35 Pages: 86-89
• [Journal Article] Pigment epithelium-derived factor (PEDF) prevent advanced glycation end products (AGEs)-elicited endothelial nitric oxide synthase (eNOS) reduction through its anti-oxidative properties. (2007)
  • Author(s): Yamagishi Sho-ichi
  • Journal Title: Protein and Peptide Letters. 14 Pages: 832-835
• [Journal Article] Pigment epithelium・derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats. (2007)
  • Author(s): Yamagishi Sho-ichi
  • Journal Title: British Journal of Ophthalmology 39 Pages: 92-97
• [Presentation] PEDF(色素上皮由来因子)はAGEs由来の酸化ストレスの産生を抑制し、初期糖尿病網膜症の発症を阻止する (2008)
  • Author(s): 松井孝憲、山岸昌一、中村和生、竹内正義、今泉勉
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-05-23
• [Presentation] PEDFは終末糖化産物(AGEs)由来の酸化ストレスの産生を抑制し、網膜微小血管への白血球の接着促進と血管透過性の亢進とを抑え、初期糖尿病網膜症の発症を阻止する。 (2007)
  • Author(s): 松井 孝憲
  • Organizer: 第15回 日本血管生物医学会学術大会
  • Place of Presentation: 九州大学医学部 百年講堂
  • Year and Date: 2007-11-30