Evaluation of diaphragmatic hernia repair using PLGA-collagen hybrid mesh

• Project/Area Number: 19791306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: University of Tsukuba
• Principal Investigator: URITA Yasuhisa University of Tsukuba, 大学院・人間総合科学研究科, 講師 (90361352)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,740,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥540,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 再生医療 / 先天性横隔膜ヘルニア / PLGA / PLGA-collagen hybrid scaffold / 間葉系幹細胞 / コラーゲン / Hybrid Scaffold

Research Abstract

PLGA mesh-collagen hybrid scaffoldはPLGAのみのscaffold同様自己の膠原線維を誘導するが、PLGAのみのものより厚い壁構造を保つため、ヘルニアの再発を防ぎ、成長障害や異物反応を起こさないscaffoldとして横隔膜ヘルニアの治療に有用である可能性が高い。間葉系幹細胞の有無は肉眼的にも、組織学的にも差異がない。筋組織の再生、誘導が今後の課題である。

Research Products

• [Journal Article] Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold : an experimental study in a rat model. (2008)
  • Author(s): Urita Y, Komuro H, Chen G, Shinya M, Saihara R, Kaneko M
  • Journal Title: Pediatric Suergery International 24 Pages: 1041-1045
  • NAID: 10027863801
  • Peer Reviewed
• [Journal Article] Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold : An experimental study in a rat model (2008)
  • Author(s): Yasuhisa Urita
  • Journal Title: Pediatric Surgery International 24 Pages: 10411045-10411045
  • NAID: 10027863801
  • Peer Reviewed
• [Presentation] 腹腔鏡補助下根治術を行った胸骨後ヘルニアの1例 (2008)
  • Author(s): 瓜田泰久 小室広昭 堀哲夫 楯川幸弘 工藤寿美 星野論子 金子道夫
  • Organizer: Pediatric Surgery Joint Meeting 2008
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-21
• [Presentation] Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold: an experimental study in rats (2007)
  • Author(s): Urita Y, Chen G, Kaneko M, Saihara R, Komuro H
  • Organizer: 1st Asian Biomaterials Congress
  • Place of Presentation: Tsukuba
  • Year and Date: 2007-12-06
• [Presentation] ラット羊膜細胞を用いた神経再生の試み (2007)
  • Author(s): 小室広昭, 瓜田泰久, 金子道夫
  • Organizer: 第43回周産期新生児医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-09
• [Presentation] Neural differencation potentials of rat amniotic cells (2007)
  • Author(s): Komuro H, Shinya M, Saihara R, Urita Y, Kaneko S, Kaneko M, Liu Y
  • Organizer: International Society for Stem Cell Research
  • Place of Presentation: Australia
  • Year and Date: 2007-06-18
• [Presentation] PLGA mesh-collagen hybrid scaffoldを用いたラット横隔膜の再生 (2007)
  • Author(s): 瓜田泰久、小室広昭、陳国平、金子道夫
  • Organizer: 第44回日本小児外科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-31
• [Presentation] PLGA mesh-collagen hybrid scaffoldを用いたラット横隔膜の再生 (2007)
  • Author(s): 瓜田泰久
  • Organizer: 第44会日本小児外科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-31
• [Presentation] Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold:An experimental study in rats. (2007)
  • Author(s): Yasuhisa, Urita
  • Organizer: 1st Asian Biomaterials Congress
  • Place of Presentation: Tsukuba, Japan