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Effects of Adipokine and Myokine on impaired wound healing in diabetes

Research Project

Project/Area Number 19791323
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

KAWAI Kenichiro  Hyogo College of Medicine, 医学部, 助教 (80423177)

Research Collaborator KAGEYAMA Akiko  兵庫医科大学, 医学部, 病院助手 (00454760)
TSUMANO Tomoko  兵庫医科大学, 医学部, 病院助手 (90449877)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,610,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywords糖尿病 / 外科 / 移植・再生医療
Research Abstract

糖尿病の合併症の一つとして、足底潰瘍に代表される創傷治癒遅延があげられる。一方、糖尿状態になると脂肪や筋肉から分泌されるadipokine やmyokineといった内分泌因子の血中濃度が増減することが知られている。本研究によりadipokineの一つであるadiponectinが、皮膚創傷治癒で重要な役割を果たしているkeratinocyteの増殖や分化に影響を与えていることを解明した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (4 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Effects of adiponectin on growth and differentiation of human keratinocytes-implication of impaired wound healing in diabetes2008

    • Author(s)
      Kawai K, Kageyama A, Tsumano T, Nishimoto S, Fukuda K, Yokoyama S, Oguma T, Fujita K, Yoshimoto S, Yanai A, Kakibuchi M.
    • Journal Title

      Biochemical and Biophysical Research Communications 374

      Pages: 269-273

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effects of adiponectin on growth and differentiation of human keratinocytes--implication of impaired wound healing in diabetes2008

    • Author(s)
      Kenichiro Kawai, Akiko Kageyama, et.al.
    • Journal Title

      Biochemical and Biophysical Research Communications 374

      Pages: 269-273

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] アディポネクチンのKeratinocyteへの影響2008

    • Author(s)
      蔭山晶子、河合建一郎、妻野知子、西本聡、福田健児、横山茂和、小熊孝、藤田和敏、吉本咲哉、柳井亜矢子、垣淵正男
    • Organizer
      第17回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 当科における基礎研究について2007

    • Author(s)
      河合 建一郎
    • Organizer
      第2回阪神形成外科セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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