Role of TFPI in disseminated intravascular coagulation
| Project/Area Number |
19791327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
ONTACHI Yasuo Kanazawa University, 医学系, 協力研究員 (80377382)
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| Research Collaborator |
ASAKURA Hidesaku 金沢大学, 附属病院, 准教授 (60192936)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | DIC / 凝固 / 線溶 / 播種性血管内凝固 / TAFI / PAI |
|---|
| Research Abstract |
新規線溶阻止因子TAFIの臨床意義は解明されていない。この度、播種性血管内凝固症候群(DIC)病態におけるTAFIおよび活性型TAFI(TAFIa)の動態を、組織因子&LPS誘発ラットDICモデルを用いて検討した。DICモデルにおいて、TAFIaは上昇したが、アルガトロバン投与により有意に抑制された。LPS 誘発DICモデルにおける臓器障害や炎症性サイトカイン上昇は、TAFIa阻害薬により軽減した。
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers.2008
Author(s)
Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T
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Journal Title
Thromb Res 123
Pages: 390-395
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of recombinant human soluble TM (ART-123) in DIC : results of phase III randomized, double-blind, clinical trial2007
Author(s)
Saito H, Maruyama I, Shimazaki S, YamamotoY, Aikawa N, Ohno R, Hirayama A, Matsuda T, Asakura H, Nakashima M, Aoki N
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Journal Title
J Thromb Haemost 5
Pages: 31-41
Related Report
Peer Reviewed
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