Serum GIial Fibrillary Acidic Protein in Post Cardiac Arrest Patients

• Project/Area Number: 19791329
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Emergency medicine
• Research Institution: Yamaguchi University
• Principal Investigator: KANEKO Tadashi Yamaguchi University, 医学部・附属病院, 助教 (50362372)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 神経学的予後 / 脳特異マーカー / 脳特異的マーカー / 中枢神経障害 / GFAP

Research Abstract

GFAPは星状細胞の骨格蛋白であり,心肺停止蘇生後において神経学的予後不良症例で上昇を認めた.神経学的予後良好症例では上昇を認めず,予後予測における特異性の高さが示唆された.従来の予後予測マーカーであるNSE(神経特異エノラーゼ), S-100B蛋白と比較し,脳低温療法による抑制などの影響を受けにくく, NSE・S-100B より血清中での脳特異性の高さが頭部外傷症例で示された.また近年報告された予後予測マーカーであるプロカルシトニン(PCT)との比較試験から,GFAP・PCTの組み合わせが今後神経学的予後予測に有用な可能性が示唆され,多施設共同研究等の前向き試験で臨床応用にむけて,今後確認していく予定である.

Research Products

• [Journal Article] Serum Glial Fibrillary Acidic Protein as a Predictive Biomarker of Neurological Outcome after Cardiac Arrest (2009)
  • Author(s): Tadashi Kaneko
  • Journal Title: RESUSCITATION (IN PRESS)
  • Peer Reviewed
• [Journal Article]
  • Author(s): Tadashi Kaneko, et al.
  • Journal Title: Resuscitation (in press)
  • Peer Reviewed
• [Presentation] (2009)
  • Author(s): 金子唯, 他
  • Organizer: 第25回日本救急医学会中国四国地方会
  • Place of Presentation: 下関
  • Year and Date: 2009-06-05
• [Presentation] (2009)
  • Author(s): Tadashi Kaneko, et al
  • Organizer: 38th Critica lCare Congress
  • Place of Presentation: Nashville Tennessee, USA
  • Year and Date: 2009-02-01
• [Presentation] Serum Glial Fibrillary Acidic Protein Has Remarkable Diagnostic Value on Traumatic Brain Injury in Multiple Trauma Patients (2009)
  • Author(s): 金子唯
  • Organizer: 38^<th> Critical Care Congress
  • Place of Presentation: Nashville, Tennessee
  • Year and Date: 2009-02-01
• [Presentation] (2008)
  • Author(s): 金子唯, 他
  • Organizer: 第36回日本救急医学会総会シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-14
• [Presentation] 心肺停止蘇生後の予後予測マーカーとしてのプロカルシトニン, GFAPの意義 (2008)
  • Author(s): 金子唯
  • Organizer: 第36回日本救急医学会総会・学術集会シンポジウム「脳低温療法のupdateと今後の展望について」
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-14
• [Presentation] (2008)
  • Author(s): 金子唯, 他
  • Organizer: 第11回日本脳低温療法学会
  • Place of Presentation: 岐阜
  • Year and Date: 2008-07-05
• [Presentation] 心肺停止蘇生後・脳低温療法時における血清GFAP値の検討 (2008)
  • Author(s): 金子唯
  • Organizer: 第11回日本脳低温療法学会
  • Place of Presentation: 岐阜
  • Year and Date: 2008-07-05
• [Presentation] (2007)
  • Author(s): Tadashi Kaneko, et al
  • Organizer: 2nd International Brain Hypothermia Symposium
  • Place of Presentation: Miami. Florida. USA
  • Year and Date: 2007-10-25
• [Presentation] Elevation of serum glial fial fibrillary acidic protein during brain hypothermia predicts neurlolgical outcome of comatose patients after out-of-hospital cardiac arrest (2007)
  • Author(s): Tadashi Kaneko
  • Organizer: 2nd International Brain Hypothermia Symposium
  • Place of Presentation: The Miami Beach Resort & Spa(Miami,Florida,USA)
  • Year and Date: 2007-10-25