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Serum GIial Fibrillary Acidic Protein in Post Cardiac Arrest Patients

Research Project

Project/Area Number 19791329
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Emergency medicine
Research InstitutionYamaguchi University

Principal Investigator

KANEKO Tadashi  Yamaguchi University, 医学部・附属病院, 助教 (50362372)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords神経学的予後 / 脳特異マーカー / 脳特異的マーカー / 中枢神経障害 / GFAP
Research Abstract

GFAPは星状細胞の骨格蛋白であり,心肺停止蘇生後において神経学的予後不良症例で上昇を認めた.神経学的予後良好症例では上昇を認めず,予後予測における特異性の高さが示唆された.従来の予後予測マーカーであるNSE(神経特異エノラーゼ), S-100B蛋白と比較し,脳低温療法による抑制などの影響を受けにくく, NSE・S-100B より血清中での脳特異性の高さが頭部外傷症例で示された.また近年報告された予後予測マーカーであるプロカルシトニン(PCT)との比較試験から,GFAP・PCTの組み合わせが今後神経学的予後予測に有用な可能性が示唆され,多施設共同研究等の前向き試験で臨床応用にむけて,今後確認していく予定である.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] Serum Glial Fibrillary Acidic Protein as a Predictive Biomarker of Neurological Outcome after Cardiac Arrest2009

    • Author(s)
      Tadashi Kaneko
    • Journal Title

      RESUSCITATION (IN PRESS)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]

    • Author(s)
      Tadashi Kaneko, et al.
    • Journal Title

      Resuscitation (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation]2009

    • Author(s)
      金子唯, 他
    • Organizer
      第25回日本救急医学会中国四国地方会
    • Place of Presentation
      下関
    • Year and Date
      2009-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation]2009

    • Author(s)
      Tadashi Kaneko, et al
    • Organizer
      38th Critica lCare Congress
    • Place of Presentation
      Nashville Tennessee, USA
    • Year and Date
      2009-02-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Serum Glial Fibrillary Acidic Protein Has Remarkable Diagnostic Value on Traumatic Brain Injury in Multiple Trauma Patients2009

    • Author(s)
      金子唯
    • Organizer
      38^<th> Critical Care Congress
    • Place of Presentation
      Nashville, Tennessee
    • Year and Date
      2009-02-01
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      金子唯, 他
    • Organizer
      第36回日本救急医学会総会シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 心肺停止蘇生後の予後予測マーカーとしてのプロカルシトニン, GFAPの意義2008

    • Author(s)
      金子唯
    • Organizer
      第36回日本救急医学会総会・学術集会シンポジウム「脳低温療法のupdateと今後の展望について」
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      金子唯, 他
    • Organizer
      第11回日本脳低温療法学会
    • Place of Presentation
      岐阜
    • Year and Date
      2008-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 心肺停止蘇生後・脳低温療法時における血清GFAP値の検討2008

    • Author(s)
      金子唯
    • Organizer
      第11回日本脳低温療法学会
    • Place of Presentation
      岐阜
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation]2007

    • Author(s)
      Tadashi Kaneko, et al
    • Organizer
      2nd International Brain Hypothermia Symposium
    • Place of Presentation
      Miami. Florida. USA
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Elevation of serum glial fial fibrillary acidic protein during brain hypothermia predicts neurlolgical outcome of comatose patients after out-of-hospital cardiac arrest2007

    • Author(s)
      Tadashi Kaneko
    • Organizer
      2nd International Brain Hypothermia Symposium
    • Place of Presentation
      The Miami Beach Resort & Spa(Miami,Florida,USA)
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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