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Recognition mechanism of intracellular group A streptococci for autophagic degradation.

Research Project

Project/Area Number 19791339
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionOsaka University (2008)
The University of Tokyo (2007)

Principal Investigator

SAKURAI Atsuo  Osaka University, 大学院・歯学研究科, 助教 (90431759)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords自然免疫 / オートファジー / レンサ球菌
Research Abstract

非貪食細胞内に侵入したA群レンサ球菌(GAS)は,オートファゴソームに取り囲まれ,リソソームと融合して分解されるが,本研究では細胞内で病原微生物の表面構造物(PAMPs)を認識する因子であるNLRファミリー遺伝子のうち,オートファジーを誘導するNLRを見出した.また,炎症応答などとの関連など,宿主免疫におけるオートファジーの役割を明らかとした.さらに,オートファジーを強く誘導する菌体表層構造を明らかとした.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (15 results)

  • [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.2010

    • Author(s)
      N. Okahashi, N. Masanobu, A. Sakurai, T. Terao, T. Hoshino, M. Yamaguchi, R. Isoda, T. Sumitomo, K. Nakano, S. Kawabata, T. Ooshima
    • Journal Title

      Biochemical and Biophysical Research Communications 391

      Pages: 1192-1196

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.2010

    • Author(s)
      N.Okahashi
    • Journal Title

      Biochem Biophys Res Commun. 391

      Pages: 1192-1196

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content.2009

    • Author(s)
      F. Maruyama, M. Kobata, K. Kurokawa, K. Nishida, A. Sakurai, K. Nakano, R. Nomura, S. Kawabata, T. Ooshima, K. Nakai, M. Hattori, S. Hamada, I. Nakagawa
    • Journal Title

      BMC genomics 10

      Pages: 358-378

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids.2009

    • Author(s)
      F. Maruyama, T. Nozawa, C. Aikawa, A. Sakurai, I. Nakagawa
    • Journal Title

      Journal of bioscience and bioengineering 107

      Pages: 471-473

    • NAID

      110007225791

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids.2009

    • Author(s)
      F.Maruyama
    • Journal Title

      Journal of bioscience and bioengineering 107

      Pages: 471-473

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content.2009

    • Author(s)
      F.Maruyama
    • Journal Title

      BMC genomics 10

      Pages: 358-378

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.2008

    • Author(s)
      A. Sakurai, N. Okahashi, F. Maruyama, T. Ooshima, S. Hamada, I. Nakagawa
    • Journal Title

      Biochemical and Biophysical Research Communications 373

      Pages: 450-454

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.2008

    • Author(s)
      A.Sakurai
    • Journal Title

      Biochem Biophys Res Commun. 373

      Pages: 450-454

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔領域レンサ球菌による宿主上皮細胞への付着侵入と炎症の誘導.2009

    • Author(s)
      桜井敦朗, 岡橋暢夫, 中田匡宣, 寺尾豊, 丸山史人, 川端重忠, 大嶋隆
    • Organizer
      第18回Lancefieldレンサ球菌研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-06-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 口腔レンサ球菌の宿主上皮細胞への付着侵入能と宿主免疫応答の解析.2009

    • Author(s)
      桜井敦朗, 船尾純子, 小畑充彦, 大嶋隆
    • Organizer
      第47回日本小児歯科学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 口腔レンサ球菌の宿主上皮細胞への付着侵入能と宿主免疫応答の解析2009

    • Author(s)
      桜井敦朗
    • Organizer
      日本小児歯科学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] A群レンサ球菌の全ゲノム発現解析に基づく細胞内生存機構の解明.2009

    • Author(s)
      大野雅幸, 丸山史人, 相川知広, 野澤孝志, 桜井敦朗, 中川一路
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Streptococcus mutansおよびS. pyogenesゲノム・トランスクリプトームからみた種分化機構の解明.2009

    • Author(s)
      丸山史人, 仲野和彦, 大野雅幸, 桜井敦朗, 野澤孝志, 大嶋隆, 浜田茂幸, 中川一路
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 細菌感染時特異的オートファジーを誘導するNLRファミリーと相互作用する宿主因子の機能解析.2009

    • Author(s)
      T. Nozawa, A. Sakurai, H. Mori, M. Ono, C. Aikawa, F. Maruyama, I. Nakagawa
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Streptococcus mutansおよびS. pyogenesゲノム・トランスクリプトームからみた種分化機構の解明.2009

    • Author(s)
      丸山史人, 大野雅幸, 森宏員, 相川知広, 野澤孝志, 桜井敦朗, 中川一路
    • Organizer
      第3回ゲノム微生物学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of minimum structure of pathogen-associated molecular pattern and the recognition mechanism in autophagy induction against group A strepcococci.2008

    • Author(s)
      Takashi Nozawa, Atsuo Sakurai, Hirokazu Mori, Masayuki Ono, Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa
    • Organizer
      The Awaji international forum on infection and immunity
    • Place of Presentation
      淡路市
    • Year and Date
      2008-09-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Group A Streptococcus transcriptome dynamics inside human cell reveals bacterial adaptation and survival against innate immune systems.2008

    • Author(s)
      Masayuki Ono, Fumito Maruyama, Takashi Nozawa, Hirokazu Mori, Chihiro Aikawa, Atsuo Sakurai, Ichiro Nakagawa
    • Organizer
      The Awaji international forum on infection and immunity
    • Place of Presentation
      淡路市
    • Year and Date
      2008-09-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 比較ゲノム・トランスクリプトーム解析に基づくStreptococcus mutansおよびS. pyogenesゲノム進化機能の解析.2008

    • Author(s)
      丸山史人, 大野雅幸, 森宏員, 相川知広, 野澤孝志, 桜井敦朗, 中川一路
    • Organizer
      第2回細菌学・若手コロッセウム
    • Place of Presentation
      神奈川県三浦郡
    • Year and Date
      2008-08-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Recognition mechanism of intracellular group A streptococci for autophagic degradation.2008

    • Author(s)
      A. Sakurai, I. Nakagawa, S. Hamada
    • Organizer
      XVII Lancefield International Symposium on Streptococci and Streptococcal Diseases
    • Place of Presentation
      Porto Heli, Greece
    • Year and Date
      2008-06-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Recognition mechanism of intracellular group A streptococci for autophagic degradation.2008

    • Author(s)
      A.Sakurai
    • Organizer
      XVII Lancefield International Symposium on Streptococci and Streptococcal Diseases.
    • Place of Presentation
      Porto Heli, Greece.
    • Year and Date
      2008-06-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] オートファジーを誘導する菌体最小構成成分の解析2008

    • Author(s)
      桜井 敦朗
    • Organizer
      日本細菌学会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recognition Mechanism and Autophagic Degradation of Intracellulary Invading Group A streptococci.2007

    • Author(s)
      Atsuo Sakurai
    • Organizer
      Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2007-09-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] シンポジウムI細胞内侵入性細菌による細胞内防御システム2007

    • Author(s)
      桜井 敦朗
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-30
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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