Analysis of the function of streptococcal heamolysin
| Project/Area Number |
19791343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NAKATA Masanobu Osaka University, 大学院歯学研究科, 助教授 (90444497)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | A 群レンサ球菌 / 溶血毒素 / A群レンサ球菌 / 病原因子 / クオラムセンシング / 増殖 |
|---|
| Research Abstract |
咽頭炎や膿痂疹の起因菌として知られるA 群レンサ球菌は様々な病原因子を産生する.同菌から産生される溶血毒素の一種であるストレプトリジンS(SLS)について新規機能を検索した結果,SLS が細菌集合体であるバイオフィルムの形成に関与することが示唆された.さらに,SLS をコードするゲノム領域に血清型特異的に存在する転写調節因子がSLS の転写に影響を与えることが明らかとなった.交付額
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M492009
Author(s)
Nakata M, Koller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, and Kreikemeyer B
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Journal Title
Infect Immun 77
Pages: 32-34
Related Report
Peer Reviewed
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[Journal Article] PlyC, a novel bacteriophage lysin for compartment-dependent proteomics of group A streptococci.2008
Author(s)
Koller, T., Nelson, D., Nakata, M., Kreutzer, M., Fischetti, V.A., Glocker, M.O., Pldbielski, A., Kreikemeyer, B.
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Journal Title
Proteomics 8
Pages: 140-148
Related Report
Peer Reviewed
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[Journal Article] The streptococcus Pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control of virulence factor expression from the noveleno ralp3 epf sagA pathogenicity region.2007
Author(s)
Kreikemeyer, B., Nakata, M., Koller, T., Hildisch, H., Kourakos, V., Standar, K., Kawabata, S., Glocker, M.O., Pldbielshi, A.
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Journal Title
Infection and Immunity 75
Pages: 5698-5710
Related Report
Peer Reviewed
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[Journal Article] Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells.2007
Author(s)
Klenk, M., Nakata, M., Podbielshi, A., Skupin, B., Schroten, H., Kreikemeyer, B.
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Journal Title
The International Society For Microbial Ecology Journal 1
Pages: 678-692
Related Report
Peer Reviewed
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