Relation between virulence and lipoprotein maturation in gram-positive pathogenic bacteria

• Project/Area Number: 19791349
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: ARIMOTO Takafumi Showa University, 歯学部, 助教 (60407393)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,540,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,500,000 (Direct Cost: ¥2,500,000)
• Keywords: lipoprotein / prolipoprotein diacylglyceryl transferase / Streptococcus mutans / binding protein / リポ蛋白質 / Lgt / S.mutans / lgt / lsp

Research Abstract

細菌リポタンパク質はリポタンパク質生合成酵素の働きで細胞膜表層上に局在し、様々な物質の取り込み、あるいは付着、薬剤耐性といった病原性への関与が示唆されている.我々は本研究期間において、グラム陽性齲蝕原性細菌を題材に用い、リポタンパク質生合成酵素による成熟が糖やアミノ酸などの物質の取り込みに及ぼす影響を調べた.その結果、細菌リポタンパク質の機能発揮には生合成酵素による成熟が必須であることを明らかにした.

Research Products

• [Journal Article] Role of prolipoprotein diacylglyceryl transferase (Lgt) and lipoprotein-specific signal peptidase II (LspA) in localization and physiological function of lipoprotein MsmE in Streptococcus mutans (2008)
  • Author(s): Arimoto T, Igarashi T
  • Journal Title: Oral Microbiology and Immunology 23 Pages: 515-519
  • Peer Reviewed
• [Journal Article] Igarashi Takeshi Role of prolipoprotein diacylglyceryl transferase (Lgt) and lipoprotein-specific signal peptidase II (LspA)in localization and physiological function of lipoprotein MsmE in Streptococcus mutans
  • Author(s): Arimoto Takafumi
• [Presentation] Streptococcus mutansのリポタンパク質LivKの同定 (2008)
  • Author(s): 井上朝日、有本隆文、五十嵐武
  • Organizer: 歯科基礎医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-28
• [Presentation] Role of Lgt and Lsp in maltose uptake mediated by Streptococcus mutans lipoprotein MalE (2008)
  • Author(s): Arimoto T, Igarashi T
  • Organizer: American Society for Microbiology
  • Place of Presentation: Boston
  • Year and Date: 2008-06-01
• [Presentation] Streptococcus mutansのリポタンパク質livKの同定 (2008)
  • Author(s): 井上朝日, 有本隆文, 五十嵐武
  • Organizer: 第50回歯科基礎医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-18
• [Presentation] Role of Lgt and Lsp in maltose uptake mediated by Streptococcus mutans lipoprotein MalE (2008)
  • Author(s): Arimoto T, Igarashi T
  • Organizer: General 108th meeting of American Society for Microbiology
  • Place of Presentation: Boston
  • Year and Date: 2008-05-18
• [Presentation] Streptococcus mutansのリポタンパク質MalEの局在性と機能解析 (2008)
  • Author(s): 有本隆文, 五十嵐武
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-25
• [Presentation] Streptococcus mutansのリポタンパク質MalEの局在性と機能解析 (2008)
  • Author(s): 有本隆文、五十嵐武
  • Organizer: 日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-24
• [Presentation] Streptococcus mutansのLgtおよびLspの機能解析 (2007)
  • Author(s): 有本隆文, 五十嵐武
  • Organizer: The 55th Annual Meeting of the Japanese Association for Dental Research
  • Place of Presentation: 鶴見
  • Year and Date: 2007-11-17
• [Presentation] Streptococcus mutansのリポタンパク質修飾酵素prolipoprotein diacylglyceryl transferase (Lgt) の機能解析 (2007)
  • Author(s): 有本隆文, 深町はるか, 森崎弘史, 栗原華絵子, 櫨場八裕, 五十嵐武
  • Organizer: 第49回歯科基礎医学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-30
• [Presentation] Inactivation of prolipoprotein diacylglyceryl transferase (Lgt) gene affects localization and function of lipoprotein MsmE in Streptococcus mutans (2007)
  • Author(s): Arimoto T, Igarashi T
  • Organizer: General 107th meeting of American Society for Microbiology
  • Place of Presentation: Toronto
  • Year and Date: 2007-05-23
• [Presentation] Streptococcus mutansのリポ蛋白質修飾酵素(Lgt)欠損株におけるMsmEリポ蛋白質の細胞局在性と機能発現の変化 (2007)
  • Author(s): 有本隆文、深町はるか、森崎弘史、栗原華絵子、五十嵐武
  • Organizer: 第80回日本細菌学会
  • Place of Presentation: 金澤
• [Presentation] Inactivation of prolipoprotein diacylglyceryl transferase(Lgt)gene affects localization and function of lipoprotein MsmE in Streptococcus mutans. (2007)
  • Author(s): 有本隆文、五十嵐武
  • Organizer: American Society for Microbiology
  • Place of Presentation: Toront
• [Presentation] Streptococcus mutansのリポ蛋白質修飾酵素prolipoprotein diacylglyceryl transferase (Lgt)およびlipoprotein singnal peptidase (Lsp)の機能解析 (2007)
  • Author(s): 有本隆文、深町はるか、森崎弘史、栗原華絵子、櫨場八裕、五十嵐武
  • Organizer: 第49回歯科基礎医学会・総会
  • Place of Presentation: 札幌