The elucidation of the mechanisms of dexamethasone-regulated osteoblast differentiation
| Project/Area Number |
19791351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
MIKAMI Yoshikazu Nihon University, 歯学部, 助教 (80434075)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,860,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | デキサメサゾン / 骨芽細胞 / BMP-2 / STAT3 |
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| Research Abstract |
In this study, we investigated the mechanisms by which dexamethasone (Dex) affects osteoblast differentiation. This study demonstrated that Dex regulated osteoblast differentiation on the cell-differentiation stage dependent manner, and that MAP kinase and Jak-STAT signaling pathway were involved in the mechanisms for the Dex-regulated osteoblast differentiation.
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Report
(4 results)
Research Products
(9 results)
