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Association of oral streptococci with the host cells in the pathogenesis of infective endocariditis

Research Project

Project/Area Number 19791352
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

YAJIMA Ayako  The Nippon Dental University, 生命歯学部, 助教 (00287773)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsStreptococcus gordonii / 感染性心内膜炎 / アドへジン / レセプター / S. gordonii / アドヘジン / シアル酸 / HL-60 / 赤血球
Research Abstract

Streptococcus gordoniiは、歯垢を形成する細菌の一つで、感染性心内膜炎の原因菌としても注目されている。感染性心内膜炎の発症には、局所で菌体と血球系の細胞が結合し、疣贅といわれる大きな固まりを作ることが重要だと考えられている。そこで、これらの宿主細胞とS. gordoniiの付着様式や各宿主細胞のレセプターの同定を試みた。その結果、赤血球では主にGlycophorin Aとband3、単球とマクロファージではCD11bとCD43、好中球ではCD11b、CD43とCD50がレセプターであることが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Binding of the Streptococcus gordonii DL1 surface protein Has to the host cell membrane glycoproteins CD11b, CD43, and CD502008

    • Author(s)
      Yumiko Urano-Tashiro, Ayako Yajima, Eizo Takashima, Yukihiro Takahashi, and Kiyoshi Konishi
    • Journal Title

      Infection and Immunity 76

      Pages: 4986-4991

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Has, an adhesin of Streptococcus gordonii DL1, binds to a2-3 Linked sialic acid on Glycophorin A of the erythrocyte membrane.2008

    • Author(s)
      Ayako Yajima, Yumiko Urano, Kisaki Shimazu, Eizo Takashima, Yukihiro Takahashi, and Kiyoshi Konishi.
    • Journal Title

      Microbiology and Immunology 52

      Pages: 69-77

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Binding of the Streptococcus gordonii DL1 surface protein Hsa to the host cell membrane glycoproteins CD11b, CD43, and CD502008

    • Author(s)
      Yumiko Urano-Tahiro, Ayako Yajima, Eizo Takashima, Yukihiro Takahashi, and Kiyoshi Konishi
    • Journal Title

      Infection and Immunity 76

      Pages: 4986-91

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hsa, an Adhesin of Streptococcus gordonii DL1, binds to α2-3-Linked Sialic Acid on Glycophorin A of the Erythrocyte Membrane2008

    • Author(s)
      Ayako Yajima, Yumiko Urano, Kisaki Shimazu, Eizo Takashima, Yukihiro Takahashi and Kiyoshi Konishi
    • Journal Title

      Microbiology and Immunology 52

      Pages: 69-77

    • NAID

      10025691165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Erythrocyte membrane receptors for Streptococcus gordonii sialic acid-binding adhesin2008

    • Author(s)
      Ayako Yajima, Yukihiro Takahashi, Yumiko Urano-Tashiro, Kisaki Shimazu, Eizo Takashima, and Kiyoshi Konishi
    • Organizer
      International Association for Dental Research 86th General Session & Exhibition
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Erythrocyte Membrane Receptors for Streptococcus gordonii Sialic AcidBinding Adhesin2008

    • Author(s)
      Ayako Yajima, Yukihiro Takahashi, Yumiko Urano-Tashiro, Kisaki Shimazu, Eizo Takashima, and Kiyoshi Konishi
    • Organizer
      International Association for Dental Research 86th General Session & Exhibition
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Streptococcus gordonii DL1株シアル酸結合性アドへジンの赤血球レセプターの同定2008

    • Author(s)
      矢島彩子、高橋幸裕、浦野有美子、島津貴咲、高島英造、古西清司
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-03-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Streptococcus gordonii DL1株シアル酸結合性アドヘジンの赤血球レセプターの同定2008

    • Author(s)
      矢島彩子、高橋幸裕、浦野有美子、島津貴咲、高島英造、古西清司
    • Organizer
      第81回 日本細菌学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Streptococcus gordonii DL1株シアル酸結合性アドへジンの赤血球レセプターの同定.2007

    • Author(s)
      矢島彩子、浦野有美子、島津貴咲、高島英造、高橋幸裕、古西清司
    • Organizer
      第49回歯科基礎医学会総会.
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Streptococcus gordonii DL1株シアル酸結合性アドヘジンの赤血球レセプターの同定2007

    • Author(s)
      矢島彩子、浦野有美子、島津貴咲、高島英造、高橋幸裕、古西清司
    • Organizer
      第49回 歯科基礎医学会総会
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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