Roles of a novel signaling molecule in salivary secretion

• Project/Area Number: 19791368
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: TAKEUCHI Hiroshi Kyushu University, 大学院・歯学研究院, 助教 (70304813)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: シグナル伝達 / 分泌機構 / イノシトールリン脂質 / カルシウム / リン酸化 / イノシトール化合物

Research Abstract

新しい情報伝達タンパク質分子、PRIPを見いだした。この分子の唾液分泌における役割を解明するための第一歩として、細胞の種々の分泌現象に対する影響を調べた。PRIPを持っていない細胞と持たせる様に遺伝子で強制的に発現させた細胞を用いて比較しながら、多面的に分泌現象を調べると、PRIPは分泌現象に抑制的に作用していることが分かった。

Research Products

• [Journal Article] Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphatevia the PH domain (2009)
  • Author(s): Gao, J., Takeuchi, H., Zhao, Z., Fujii, M., Kanematsu, T. and Hirata, M
  • Journal Title: Cell. Signal 21 Pages: 1180-1186
  • Peer Reviewed
• [Journal Article] Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain (2009)
  • Author(s): 高靖
  • Journal Title: Cellular Signaling (印刷中)
  • Peer Reviewed
• [Journal Article] Signaling pathways regulating IL-1 alpha-induced COX-2 expression (2007)
  • Author(s): Ogata, S., Kubota, Y., Yamashiro, T., Takeuchi, H., Ninomiya, T., Suyama, Y. and Shirasuna, K.
  • Journal Title: J. Dent.J. Dent. 86 Pages: 186-191
  • Peer Reviewed
• [Journal Article] 咬合不全はGABAA受容体の機能異常を引き起こすか (2007)
  • Author(s): 竹内弘
  • Journal Title: 九州地区連合歯科医師会会務報告書 Pages: 22-24
• [Presentation] Roles for the membrane localization of pleckstrin homology domain from phospholipase C-related inactive protein in dense-core vesicle exocvtosis (2008)
  • Author(s): 高靖
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] Intramolecular inhibition in the membrane localization of pleckstrin homology domain from phospholipase C-related inactive protein (2008)
  • Author(s): Gao, J., Takeuchi, H., Kanematsu, T. and Hirata, M
  • Organizer: 33rd FEBS Congress and 11th IUBMB Conference
  • Place of Presentation: Athens, Greece
• [Presentation] 咀噛が脳におけるGABAA受容体分子に及ぼす影響の解析 (2008)
  • Author(s): 竹内弘、兼松隆、平田雅人
  • Organizer: 第50回歯科基礎医学会学術大会・総会
  • Place of Presentation: 東京都江東区
• [Presentation] Roles for the membrane localization of pleckstrin homology domain from phospholipase C-related inactive protein in dense-core vesicle exocytosis (2008)
  • Author(s): 高靖、竹内弘、兼松隆、平田雅人
  • Organizer: 第31回日本日本分子生物学会年会・第80回日本生化学大会合同大会
  • Place of Presentation: 神戸市
• [Presentation] Phox homology domain containing protein kinase-like protein is involved in receptor trafficking (2008)
  • Author(s): 竹内弘、高靖、平田雅人
  • Organizer: 第31回日本日本分子生物学会年会・第81回日本生化学大会合同大会
  • Place of Presentation: 神戸市
• [Presentation] A new member of phox homology domain-containing protein family binds actin ?? and is involved in receptor trafficking (2007)
  • Author(s): Takeuchi, H
  • Organizer: KUSCR Japan/Korea Symposium on Cellular Signaling
  • Place of Presentation: Fukuoka
  • Year and Date: 2007-12-17
• [Presentation] Differential membrane locahzation of pleckstrin homology domains from 2 isoforoms of phospholipase C-related inactive protein. (2007)
  • Author(s): 高靖、竹内弘、兼松隆、平田雅人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] 開口分泌現象へのPRIP分子の関わり (2007)
  • Author(s): 竹内弘、兼松隆、松田美穂、塩井誠次郎、平田雅人
  • Organizer: 第117回日本薬理学会関東部会
  • Place of Presentation: 東京都
  • Year and Date: 2007-10-06
• [Presentation] Intramolecular regulation in membrane localization of pleckstrin homology domain of PRIP (2007)
  • Author(s): Gao, J., Takeuchi, H., Kanematsu, T. and Hirata, M
  • Organizer: The 5th Korea-Japan Conference on Cellular Signaling for Young
  • Place of Presentation: Scientists, Gyeongju
• [Presentation] A multimodular protein, phox homology domain-containing protein kinase like protein, binds actin and is involved in receptor trafficking (2007)
  • Author(s): Takeuchi, H., Gao, J., Cantley, L.C. and Hirata, M
  • Organizer: International Symposium in Membrane Traffic
  • Place of Presentation: Awaji Yumebutai
• [Presentation] Differential membrane localization of pleckstrin homology domains from 2 isoforms of phospho- lipase C-related inactive protein (2007)
  • Author(s): Gao, J., Takeuchi, H., Kanematsu, T. and Hirata, M
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
  • Place of Presentation: 横浜市
• [Presentation] PXK, phox homology domain containing protein kinase-like protein, is an actin binding protein involved in receptor trafficking (2007)
  • Author(s): Takeuchi, H., Gao, J., Cantley, L.C. and Hirata, M
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
  • Place of Presentation: 横浜市
• [Remarks]
  • URL: http://www.dent.kyushu-u.ac.jp/sosiki/a04/index.html
• [Remarks]
  • URL: http://www.dent.kyushu-u.ac.jp/sosiki/a04/index.html
• [Remarks]
  • URL: http://www.dent.kyushu-u.ac.jp/sosiki/a04/index.html