| Project/Area Number |
19791377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
MORITA Ayami Aichi Gakuin University, 薬学部, 助教 (70301629)
|
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | lysophosphatidic acid / IL-6 / IL-8 / osteoblasts / RANKL / OPG / osteoblast / proliferation / vitamin K_2 / osteoprotegerin / mTOR / NF-κB / 骨芽細胞 / osteocalcin / vitamin K2 / IL-Iβ / Lysophosphatidic acid / interleukin-6 / interleukin-8 |
|---|
| Research Abstract |
In the present study, I demonstrated that LPA stimulated the production of IL-6 and IL-8 via the activation of PLC and IP_3 receptor-mediated intracellular calcium release in human osteoblasts. In contrast, the present results underline the importance of mTOR kinase acting as regulator of OPG production in mouse stromal cells. Furthermore, these results underline the cascade leading to NGF production, suggesting that mouse osteoblastic cells secrete NGF through the suppression of NF_<-KB> nuclear translocation. If key signal cascade for these regulators of bone-metabolism can be elucidated, it can open the door for a new therapy for bone-destructive diseases by means of controlling these productions.
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