nvestigation of the behavior of nuclear proteins in human cancer cells
Project/Area Number |
19791383
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Kyushu Dental College |
Principal Investigator |
KITO Shinji Kyushu Dental College, 歯学部, 助教 (80347682)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥2,780,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
|
Keywords | 悪性腫瘍細胞 / アポトーシス / AgNORs / ニュークレオリン / ニュークレオフォスミン / UV照射 / nucleolin / nucleophosmin / RNAi / FDG-PET / nucleophosmn / 癌幹細胞 / iPS細胞 / 抗癌剤 / クロマチン |
Research Abstract |
To investigate the behavior of nucleolin and AgNORs proteins in ultra-violet ray (UV)-induced oral cancer apoptotic cells. Dynamic alteration of nucleolin and AgNORs proteins in UV-induced SCC-25 and HSG cells were examined using Western blot analysis and histocytochemistry methods. Dynamic alteration of nucleolin and AgNORs proteins are observed. Nucleolin disappeared or diffusely spread out into nucleus in apoptotic body of oral cancer cells. This results indicate that alteration of nucleolin is associated with the induction of DNA fragmentation or the final active phase of apoptosis induced by UV in oral cancer cells.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Importance of clinical features and CT findings in numb chin syndrome: report of two cases.2009
Author(s)
Yoshioka I, Shiiba S, Tanaka T, Nishikawa T, Sakamoto E, Kito S, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Kagawa S, Nakanishi O, Tominaga K, Morimoto Y
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Journal Title
J Am Dent Assoc 140
Pages: 550-4
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[Journal Article] Double contour-like structures", characteristic magnetic resonance signals on mandibular condyles seen during child growth.2009
Author(s)
Tanaka T, Konoo T, Yoshioka I, Habu M, Kito S, Kodama M, Oda M, Wakasugi-Sato N, Matsumoto S, Kagawa S, Terashita M, Tominaga K, Morimoto Y
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Journal Title
In RESEARCH ADVANCES IN ORAL DISEASES 1(GLOBAL RESEARCH NETWORK, INDIA)
Pages: 15-22
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[Journal Article] Dynamic magnetic resonance sialography for patients with xerostomia.2008
Author(s)
Tanaka T, Ono K, Ansai T, Yoshioka I, Habu M, Tomoyose T, Yamashita Y, Nishida I, Oda M, Kuroiwa H, Wakasugi-Sato N, Okabe S, Kito S, Takahashi T, Tominaga K, Inenaga K, Morimoto Y
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(1)
Pages: 115-23
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[Journal Article] Assessment of the relationship between the mandibular cortex on panoramic radiographs and the risk of bone fracture and vascular disease in 80-year-olds.2008
Author(s)
Okabe S, Morimoto Y, Ansai T, Yoshioka I, Tanaka T, Taguchi A, Kito S, Wakasugi-Sato N, Oda M, Kuroiwa H, Ohba T, Awano S, Takata Y, Takehara T
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(3)
Pages: 433-42
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[Journal Article] Usefulness of CT scan images for planning the bone cut for intra-oral vertical ramus osteotomy.2008
Author(s)
Yoshioka I, Tanaka T, Oda M, Kodama M, Habu M, Kito S, Okabe S, Wakasugi-Sato N, Kuroiwa H, Tominaga K, Morimoto Y
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Journal Title
J Maxillofac Oral Surg 7
Pages: 245-250
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[Journal Article] Usefulness of CT scan images for planning the bone cut for intra oral vertical ramus oste otomy2008
Author(s)
Yoshioka I, Tanaka T, Oda M, Kodama M, Habu M, Kito S, Okabe S, Wakasugi-Sato N, Kuroiwa H, Tominaga K, Morimoto Y
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Journal Title
J Maxillofac Oral Surg. 7
Pages: 245-250
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Peer Reviewed
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[Journal Article] Assessment of the relationship between the mandibular cortex on panoramic radiographs an d the risk of fractures and vascular diseases in 80year-olds2008
Author(s)
Okabe S, Morimoto Y, Ansai T, Yoshioka I, Tanaka T, Taguchi A, Kito S, Wakasu gi-Sato N, Oda M, Kuroiwa H, Ohba T, Awano S, Takata Y, Takehara T
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106
Pages: 433-42
Related Report
Peer Reviewed
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[Journal Article] Dynamic MR sialography for patients with xerostomia2008
Author(s)
Tanaka T, Ono K, Ansai T, Yoshioka I, Habu M, Tomoyose T, Yamashita Y, Nis hida I, Oda M, Kuroiwa H, Wakasugi-Sato N, Okabe S, Kito S Takahashi T, Tominaga K, Inenaga K, Morimoto Y
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106
Pages: 939-47
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Peer Reviewed
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[Journal Article] Functional evaluations of the parotid and submandibular glands using dynamic MR sialography.2007
Author(s)
Tanaka T, Ono K, Habu M, Inoue H, Tominaga K, Okabe S, Kito S, Yokota M, Fukuda J, Inenaga K, Morimoto Y
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Journal Title
Dentomaxillofac Radiol 36
Pages: 218-223
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[Journal Article] Functional evaluations of the parotid and submandibular glandsusing dynamic MR sialography.2007
Author(s)
Tanaka T, Ono K, Habu M, Inoue H, Tominaga K, OkabeS, Kito S, Yokota M, FukudaJ, Inenaga K, Morimoto Y
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Journal Title
Dentomaxillofac Radiol. 36
Pages: 218-223
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Peer Reviewed
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[Presentation] Correlation between the incidence of central nodal necrosis in neck node metastasis and the degree of differentiation in oral squamous cell carcinoma.2008
Author(s)
S Kito, A Uchida, T Tanaka, N Wakasugi-Sato, S Matsumoto-Takeda, M Oda, T Hiromatsu1), K Harada2), K Hori3), I Yoshioka, Y Morimoto
Organizer
The 7th Asian Congress of Oral and Maxillofacial Radiology and The 13th Conference of Clinical Diagnostics of JSOMR
Place of Presentation
Nara, Japan
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[Book] New diagnostic imaging modalities for oral cancers (Chapter 5). In Oral Cancer Research Advances.2007
Author(s)
Morimoto Y, Tanaka T, Yoshioka I, Yamashita Y, Hirashima S, Kodama M, Ariyoshi W, Tomoyose T, Furuta N, Habu M, Okabe S, Kito S, Oda M, Kuroiwa H, Wakasugi-Sato N, Takahashi T, Tominaga K
Publisher
Nova Science Publishers
Related Report